Q9SFD5 · TAD2A_ARATH

Function

function

Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity).
ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region

Features

Showing features for binding site.

154850100150200250300350400450500
TypeIDPosition(s)Description
Binding site53Zn2+ 1 (UniProtKB | ChEBI)
Binding site56Zn2+ 1 (UniProtKB | ChEBI)
Binding site68Zn2+ 2 (UniProtKB | ChEBI)
Binding site71Zn2+ 2 (UniProtKB | ChEBI)
Binding site77Zn2+ 1 (UniProtKB | ChEBI)
Binding site80Zn2+ 1 (UniProtKB | ChEBI)
Binding site90Zn2+ 2 (UniProtKB | ChEBI)
Binding site94Zn2+ 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Molecular Functionchromatin binding
Molecular FunctionDNA binding
Molecular Functiontranscription coactivator activity
Molecular Functionzinc ion binding
Biological Processchromatin remodeling
Biological Processregulation of transcription by RNA polymerase II

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcriptional adapter ADA2a
  • Short names
    AtADA2a

Gene names

    • Name
      ADA2A
    • Synonyms
      HAC10, HXA02, HXA2
    • ORF names
      F17A17.8, MLP3.19
    • Ordered locus names
      At3g07740

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SFD5
  • Secondary accessions
    • Q9SSE2

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis257No phenotypic effect.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain, modified residue.

Type
IDPosition(s)Description
ChainPRO_00002697501-548Transcriptional adapter ADA2a
Modified residue257N6-acetyllysine; by GCN5

Post-translational modification

Acetylated in vitro by GCN5, but acetylation is not essential for biological activity.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in roots and leaves.

Gene expression databases

Interaction

Subunit

Interacts in vitro with the HAT domain of GCN5 and with the DNA-binding domain of the transcriptional activator DREB1B/CBF1.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntAct
BINARY Q9SFD5GT-3A Q9SDW04EBI-979206, EBI-9348720
BINARY Q9SFD5HAG1 Q9AR195EBI-979206, EBI-979271
BINARY Q9SFD5HSFC1 Q9LV525EBI-979206, EBI-4457746
BINARY Q9SFD5MYB70 O221793EBI-979206, EBI-1238013
BINARY Q9SFD5PYL6 Q8S8E33EBI-979206, EBI-2363192
BINARY Q9SFD5PYL9 Q84MC73EBI-979206, EBI-2349513
BINARY Q9SFD5TCP13 Q9S7W54EBI-979206, EBI-4424877
BINARY Q9SFD5TCP14 Q93Z003EBI-979206, EBI-4424563

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for compositional bias, region, zinc finger, domain, coiled coil.

Type
IDPosition(s)Description
Compositional bias1-26Basic and acidic residues
Region1-30Disordered
Zinc finger48-104ZZ-type
Domain106-158SANT
Coiled coil365-386
Domain461-548SWIRM

Domain

The middle domain of ADA2a is sufficient for interaction with the HAT catalytic domain of GCN5.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9SFD5-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    548
  • Mass (Da)
    62,042
  • Last updated
    2000-05-01 v1
  • Checksum
    5B2BDA01D4C9F67F
MGRSKLASRPAEEDLNPGKSKRKKISLGPENAAASISTGIEAGNERKPGLYCCNYCDKDLSGLVRFKCAVCMDFDLCVECFSVGVELNRHKNSHPYRVMDNLSFSLVTSDWNADEEILLLEAIATYGFGNWKEVADHVGSKTTTECIKHFNSAYMQSPCFPLPDLSHTIGKSKDELLAMSKDSAVKTEIPAFVRLSPKEELPVSAEIKHEASGKVNEIDPPLSALAGVKKKGNVPQAKDIIKLEAAKQQSDRSVGEKKLRLPGEKVPLVTELYGYNLKREEFEIEHDNDAEQLLADMEFKDSDTDAEREQKLQVLRIYSKRLDERKRRKEFVLERNLLYPDQYEMSLSAEERKIYKSCKVFARFQSKEEHKELIKKVIEEHQILRRIEDLQEARTAGCRTTSDANRFIEEKRKKEAEESMLLRLNHGAPGSIAGKTLKSPRGLPRNLHPFGSDSLPKVTPPRIYSGLDTWDVDGLLGADLLSETEKKMCNETRILPVHYLKMLDILTREIKKGQIKKKSDAYSFFKVEPSKVDRVYDMLVHKGIGDST

Q9SFD5-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A8MRD5A8MRD5_ARATHADA2A527
F4JFM6F4JFM6_ARATHADA2A555

Sequence caution

The sequence AAF13092.1 differs from that shown. Reason: Erroneous gene model prediction

Features

Showing features for compositional bias, alternative sequence.

Type
IDPosition(s)Description
Compositional bias1-26Basic and acidic residues
Alternative sequenceVSP_0220941-71in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF338769
EMBL· GenBank· DDBJ
AAK31319.1
EMBL· GenBank· DDBJ
mRNA
AC009176
EMBL· GenBank· DDBJ
AAF13092.1
EMBL· GenBank· DDBJ
Genomic DNA Sequence problems.
AC013483
EMBL· GenBank· DDBJ
AAF21184.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE74594.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE74595.1
EMBL· GenBank· DDBJ
Genomic DNA
AY040045
EMBL· GenBank· DDBJ
AAK64103.1
EMBL· GenBank· DDBJ
mRNA
AF360246
EMBL· GenBank· DDBJ
AAK25956.1
EMBL· GenBank· DDBJ
mRNA
BX824819
EMBL· GenBank· DDBJ
-mRNA No translation available.
DR751137
EMBL· GenBank· DDBJ
-mRNA No translation available.
DR751119
EMBL· GenBank· DDBJ
-mRNA No translation available.

Genome annotation databases

Similar Proteins

Disclaimer

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