Q9SFD5 · TAD2A_ARATH
- ProteinTranscriptional adapter ADA2a
- GeneADA2A
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids548 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Required for the function of some acidic activation domains, which activate transcription from a distant site. The exact mechanism of action is not yet known (By similarity).
ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region
ADA2 stimulates the acetyltransferase activity of GCN5 on free histones or nucleosomes, probably by opening up the promoter region
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 53 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 56 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 68 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 71 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 77 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 80 | Zn2+ 1 (UniProtKB | ChEBI) | |||
Binding site | 90 | Zn2+ 2 (UniProtKB | ChEBI) | |||
Binding site | 94 | Zn2+ 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | DNA binding | |
Molecular Function | transcription coactivator activity | |
Molecular Function | zinc ion binding | |
Biological Process | chromatin remodeling | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTranscriptional adapter ADA2a
- Short namesAtADA2a
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SFD5
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Mutagenesis | 257 | No phenotypic effect. | |||
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 24 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000269750 | 1-548 | Transcriptional adapter ADA2a | ||
Modified residue | 257 | N6-acetyllysine; by GCN5 | |||
Post-translational modification
Acetylated in vitro by GCN5, but acetylation is not essential for biological activity.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Interacts in vitro with the HAT domain of GCN5 and with the DNA-binding domain of the transcriptional activator DREB1B/CBF1.
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | IntAct | |
---|---|---|---|---|---|
BINARY | Q9SFD5 | GT-3A Q9SDW0 | 4 | EBI-979206, EBI-9348720 | |
BINARY | Q9SFD5 | HAG1 Q9AR19 | 5 | EBI-979206, EBI-979271 | |
BINARY | Q9SFD5 | HSFC1 Q9LV52 | 5 | EBI-979206, EBI-4457746 | |
BINARY | Q9SFD5 | MYB70 O22179 | 3 | EBI-979206, EBI-1238013 | |
BINARY | Q9SFD5 | PYL6 Q8S8E3 | 3 | EBI-979206, EBI-2363192 | |
BINARY | Q9SFD5 | PYL9 Q84MC7 | 3 | EBI-979206, EBI-2349513 | |
BINARY | Q9SFD5 | TCP13 Q9S7W5 | 4 | EBI-979206, EBI-4424877 | |
BINARY | Q9SFD5 | TCP14 Q93Z00 | 3 | EBI-979206, EBI-4424563 |
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for compositional bias, region, zinc finger, domain, coiled coil.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-26 | Basic and acidic residues | |||
Region | 1-30 | Disordered | |||
Zinc finger | 48-104 | ZZ-type | |||
Domain | 106-158 | SANT | |||
Coiled coil | 365-386 | ||||
Domain | 461-548 | SWIRM | |||
Domain
The middle domain of ADA2a is sufficient for interaction with the HAT catalytic domain of GCN5.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9SFD5-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length548
- Mass (Da)62,042
- Last updated2000-05-01 v1
- Checksum5B2BDA01D4C9F67F
Q9SFD5-2
- Name2
- Differences from canonical
- 1-71: Missing
Computationally mapped potential isoform sequences
There are 2 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for compositional bias, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 1-26 | Basic and acidic residues | |||
Alternative sequence | VSP_022094 | 1-71 | in isoform 2 | ||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF338769 EMBL· GenBank· DDBJ | AAK31319.1 EMBL· GenBank· DDBJ | mRNA | ||
AC009176 EMBL· GenBank· DDBJ | AAF13092.1 EMBL· GenBank· DDBJ | Genomic DNA | Sequence problems. | |
AC013483 EMBL· GenBank· DDBJ | AAF21184.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE74594.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE74595.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY040045 EMBL· GenBank· DDBJ | AAK64103.1 EMBL· GenBank· DDBJ | mRNA | ||
AF360246 EMBL· GenBank· DDBJ | AAK25956.1 EMBL· GenBank· DDBJ | mRNA | ||
BX824819 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
DR751137 EMBL· GenBank· DDBJ | - | mRNA | No translation available. | |
DR751119 EMBL· GenBank· DDBJ | - | mRNA | No translation available. |