Q9SFB6 · M3KE2_ARATH

Function

function

Serine/threonine-protein kinase involved in the spatial and temporal control system organizing cortical activities in mitotic and postmitotic cells (PubMed:15292395).
Required for the normal functioning of the plasma membrane in developing pollen (PubMed:16965555).
Involved in the regulation of cell expansion and embryo development (PubMed:23087695).

Catalytic activity

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site26-34ATP (UniProtKB | ChEBI)
Binding site49ATP (UniProtKB | ChEBI)
Active site144Proton acceptor

GO annotations

AspectTerm
Cellular Componentmicrotubule organizing center
Cellular Componentnucleolus
Cellular Componentplasma membrane
Cellular Componentvacuole
Molecular FunctionATP binding
Molecular Functionprotein serine kinase activity
Molecular Functionprotein serine/threonine kinase activity
Biological Processcell division
Biological Processprotein autophosphorylation
Biological Processregulation of cell division

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    MAP3K epsilon protein kinase 2
  • EC number
  • Alternative names
    • Mitogen-activated protein kinase kinase kinase 6

Gene names

    • Name
      MAP3KE2
    • Synonyms
      MAPKKK6
    • ORF names
      F17A17.32
    • Ordered locus names
      At3g07980

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9SFB6

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Nucleus, nucleolus
Cell membrane
Note: Accumulates in the nucleolus during interphase (PubMed:15292395).
Localized to the plasma membrane in developing pollen grains (By similarity).

Keywords

Phenotypes & Variants

Disruption phenotype

Pollen lethality in plants lacking both MAP3KE1 and MAP3KE2, associated with plasma membrane irregularities following pollen mitosis I (PubMed:16965555).
Smaller plants with shorter roots due to reduced cell elongation in roots and reduced cell expansion in rosette leaves, as well as embryos arrest in the early stages of development (PubMed:23087695).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 80 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004322251-1367MAP3K epsilon protein kinase 2

Post-translational modification

Autophosphorylated.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in both the sporophytic and the gametophytic tissues, especially in dividing cells. Mostly present in flower buds and mature flowers. Accumulates also in embryos and in roots.

Induction

Expression is cell cycle-regulated, with higher expression in G2-M phases.

Developmental stage

Expressed during embryo development.

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain, repeat, region, compositional bias.

TypeIDPosition(s)Description
Domain20-274Protein kinase
Repeat25-62HEAT 1
Repeat86-125HEAT 2
Repeat218-256HEAT 3
Region285-422Disordered
Compositional bias289-309Basic and acidic residues
Compositional bias362-393Polar residues
Compositional bias394-414Basic and acidic residues
Region437-513Disordered
Compositional bias490-509Polar residues
Repeat538-576HEAT 4
Repeat577-614HEAT 5
Repeat633-658HEAT 6
Repeat659-700HEAT 7
Repeat704-742HEAT 8
Region792-860Disordered
Compositional bias795-814Polar residues
Compositional bias831-847Polar residues
Repeat850-888HEAT 9
Repeat906-943HEAT 10
Repeat1045-1066HEAT 11
Repeat1067-1105HEAT 12
Repeat1112-1150HEAT 13
Repeat1154-1191HEAT 14
Repeat1196-1236HEAT 15
Repeat1257-1280HEAT 16
Repeat1281-1317HEAT 17
Repeat1347-1367HEAT 18

Sequence similarities

Belongs to the protein kinase superfamily. Ser/Thr protein kinase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,367
  • Mass (Da)
    151,137
  • Last updated
    2000-05-01 v1
  • Checksum
    7618AFA6B41A227C
MARQMTSSQFHKSKTLDNKYMLGDEIGKGAYGRVYIGLDLENGDFVAIKQVSLENIGQEDLNTIMQEIDLLKNLNHKNIVKYLGSLKTKTHLHIILEYVENGSLANIIKPNKFGPFPESLVTVYIAQVLEGLVYLHEQGVIHRDIKGANILTTKEGLVKLADFGVATKLNEADFNTHSVVGTPYWMAPEVIELSGVCAASDIWSVGCTIIELLTCVPPYYDLQPMPALYRIVQDDTPPIPDSLSPDITDFLRLCFKKDSRQRPDAKTLLSHPWIRNSRRALRSSLRHSGTIRYMKETDSSSEKDAEGSQEVVESVSAEKVEVTKTNSKSKLPVIGGASFRSEKDQSSPSDLGEEGTDSEDDINSDQGPTLSMHDKSSRQSGTCSISSDAKGTSQDVLENHEKYDRDEIPGNLETEASEGRRNTLATKLVGKEYSIQSSHSFSQKGEDGLRKAVKTPSSFGGNELTRFSDPPGDASLHDLFHPLDKVPEGKTNEASTSTPTANVNQGDSPVADGGKNDLATKLRARIAQKQMEGETGHSQDGGDLFRLMMGVLKDDVLNIDDLVFDEKVPPENLFPLQAVEFSRLVSSLRPDESEDAIVTSSLKLVAMFRQRPGQKAVFVTQNGFLPLMDLLDIPKSRVICAVLQLINEIVKDNTDFLENACLVGLIPLVMSFAGFERDRSREIRKEAAYFLQQLCQSSPLTLQMFISCRGIPVLVGFLEADYAKHREMVHLAIDGMWQVFKLKKSTSRNDFCRIAAKNGILLRLVNTLYSLSEATRLASISGDALILDGQTPRARSGQLDPNNPIFSQRETSPSVIDHPDGLKTRNGGGEEPSHALTSNSQSSDVHQPDALHPDGDRPRLSSVVADATEDVIQQHRISLSANRTSTDKLQKLAEGASNGFPVTQPDQVRPLLSLLEKEPPSRKISGQLDYVKHIAGIERHESRLPLLYASDEKKTNGDLEFIMAEFAEVSGRGKENGNLDTAPRYSSKTMTKKVMAIERVASTCGIASQTASGVLSGSGVLNARPGSTTSSGLLAHALSADVSMDYLEKVADLLLEFARAETTVKSYMCSQSLLSRLFQMFNRVEPPILLKILECTNHLSTDPNCLENLQRADAIKQLIPNLELKEGPLVYQIHHEVLSALFNLCKINKRRQEQAAENGIIPHLMLFVMSDSPLKQYALPLLCDMAHASRNSREQLRAHGGLDVYLSLLDDEYWSVIALDSIAVCLAQDVDQKVEQAFLKKDAIQKLVNFFQNCPERHFVHILEPFLKIITKSSSINKTLALNGLTPLLIARLDHQDAIARLNLLKLIKAVYEKHPKPKQLIVENDLPQKLQNLIEERRDGQRSGGQVLVKQMATSLLKALHINTIL

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1I9LPC2A0A1I9LPC2_ARATHMAPKKK61343
A0A1I9LPC3A0A1I9LPC3_ARATHMAPKKK61182

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias289-309Basic and acidic residues
Compositional bias362-393Polar residues
Compositional bias394-414Basic and acidic residues
Compositional bias490-509Polar residues
Compositional bias795-814Polar residues
Compositional bias831-847Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC013483
EMBL· GenBank· DDBJ
AAF21208.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002686
EMBL· GenBank· DDBJ
AEE74627.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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