Q9SDD6 · PRX2F_ORYSJ

Function

function

Thiol-specific peroxidase that catalyzes the reduction of hydrogen peroxide and organic hydroperoxides to water and alcohols, respectively. Plays a role in cell protection against oxidative stress by detoxifying peroxides. Reduces preferentially hydrogen peroxide rather than alkyl peroxides. May be involved in mitochondrial redox homeostasis.

Miscellaneous

The active site is a conserved redox-active cysteine residue, the peroxidatic cysteine (C(P)), which makes the nucleophilic attack on the peroxide substrate. The peroxide oxidizes the C(P)-SH to cysteine sulfenic acid (C(P)-SOH), which then reacts with another cysteine residue, the resolving cysteine (C(R)), to form a disulfide bridge. The disulfide is subsequently reduced by an appropriate electron donor to complete the catalytic cycle. In this 1-Cys peroxiredoxin, no C(R) is present and C(P) instead forms a disulfide with a cysteine from another protein or with a small thiol molecule. C(P) can be reactivated by glutathione or the mitochondrial glutaredoxin (Grx) or thioredoxin (Trx) systems.

Catalytic activity

Features

Showing features for active site.

TypeIDPosition(s)Description
Active site86Cysteine sulfenic acid (-SOH) intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Cellular Componentmitochondrial matrix
Cellular Componentmitochondrion
Molecular Functionthioredoxin peroxidase activity
Biological Processcell redox homeostasis
Biological Processcellular response to oxidative stress
Biological Processhydrogen peroxide catabolic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Peroxiredoxin-2F, mitochondrial
  • EC number
  • Alternative names
    • Glutaredoxin-dependent peroxiredoxin
    • Peroxiredoxin IIF
    • Thioredoxin peroxidase 2F

Gene names

    • Name
      PRXIIF
    • ORF names
      P0011D01.6, P0499C11.34
    • Ordered locus names
      Os01g0266600, LOC_Os01g16152

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Nipponbare
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > Liliopsida > Poales > Poaceae > BOP clade > Oryzoideae > Oryzeae > Oryzinae > Oryza > Oryza sativa

Accessions

  • Primary accession
    Q9SDD6
  • Secondary accessions
    • B7E2T3

Proteomes

Genome annotation databases

Subcellular Location

PTM/Processing

Features

Showing features for transit peptide, chain.

TypeIDPosition(s)Description
Transit peptide1-27Mitochondrion
ChainPRO_000028296228-198Peroxiredoxin-2F, mitochondrial

Proteomic databases

Interaction

Subunit

Monomer.

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain34-198Thioredoxin

Sequence similarities

Belongs to the peroxiredoxin family. Prx5 subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    198
  • Mass (Da)
    20,874
  • Last updated
    2000-05-01 v1
  • Checksum
    21362AB6D2964CCD
MASALLRKATVGGSAAAAAARWASRGLASVGSGSDIVSAAPGVSLQKARSWDEGVATNFSTTPLKDIFHGKKVVIFGLPGAYTGVCSQAHVPSYKNNIDKLKAKGVDSVICVSVNDPYALNGWAEKLQAKDAIEFYGDFDGSFHKSLDLEVDLSAALLGRRSHRWSAFVDDGKIKAFNVEVAPSDFKVSGAEVILDQI

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AP000969
EMBL· GenBank· DDBJ
BAA88530.1
EMBL· GenBank· DDBJ
Genomic DNA
AP001080
EMBL· GenBank· DDBJ
BAA90363.1
EMBL· GenBank· DDBJ
Genomic DNA
AP008207
EMBL· GenBank· DDBJ
BAF04594.1
EMBL· GenBank· DDBJ
Genomic DNA
AP014957
EMBL· GenBank· DDBJ
BAS71469.1
EMBL· GenBank· DDBJ
Genomic DNA
AK058396
EMBL· GenBank· DDBJ
BAG86680.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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