Q9SCP7 · NAMT1_ARATH
- ProteinNicotinate N-methyltransferase 1
- GeneNANMT1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids359 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Involved in nicotinate detoxification in planta (PubMed:28533213).
Catalyzes the conversion of nicotinate to N-methylnicotinate, which is a detoxified form of endogenous nicotinate in planta (PubMed:28533213).
Catalyzes the conversion of nicotinate to N-methylnicotinate, which is a detoxified form of endogenous nicotinate in planta (PubMed:28533213).
Catalytic activity
- nicotinate + S-adenosyl-L-methionine = N-methylnicotinate + S-adenosyl-L-homocysteineThis reaction proceeds in the forward direction.
Kinetics
KM | SUBSTRATE | pH | TEMPERATURE[C] | NOTES | EVIDENCE | |
---|---|---|---|---|---|---|
38.7 μM | nicotinate | |||||
52.13 μM | S-adenosyl-L-methionine |
kcat is 3.52 sec-1 with nicotinate as substrate (PubMed:28533213).
kcat is 3.01 sec-1 with S-adenosyl-L-methionine as substrate (PubMed:28533213).
kcat is 3.01 sec-1 with S-adenosyl-L-methionine as substrate (PubMed:28533213).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | methyltransferase activity | |
Molecular Function | nicotinate N-methyltransferase activity | |
Molecular Function | O-methyltransferase activity | |
Molecular Function | protein dimerization activity | |
Biological Process | methylation | |
Biological Process | nicotinate metabolic process |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNicotinate N-methyltransferase 1
- EC number
- Short namesAtNANMT1
Gene names
Organism names
- Strain
- Taxonomic lineageEukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis
Accessions
- Primary accessionQ9SCP7
- Secondary accessions
Proteomes
Organism-specific databases
Genome annotation databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 21 | Reduces catalytic activity 4-fold. | ||||
Sequence: N → S | ||||||
Mutagenesis | 120 | Reduces catalytic activity 2-fold. | ||||
Sequence: Y → L | ||||||
Mutagenesis | 124 | Loss of catalytic activity. | ||||
Sequence: H → N | ||||||
Mutagenesis | 264 | Loss of catalytic activity. | ||||
Sequence: T → H |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000451460 | 1-359 | Nicotinate N-methyltransferase 1 | |||
Sequence: MENESSESRNRARLAIMELANMISVPMSLNAAVRLGIADAIWNGGANSPLSAAEILPRLHLPSHTTIGGDPENLQRILRMLTSYGVFSEHLVGSIERKYSLTDVGKTLVTDSGGLSYAAYVLQHHQEALMRAWPLVHTAVVEPETEPYVKANGEAAYAQYGKSEEMNGLMQKAMSGVSVPFMKAILDGYDGFKSVDILVDVGGSAGDCLRMILQQFPNVREGINFDLPEVVAKAPNIPGVTHVGGDMFQSVPSADAIFMKWVLTTWTDEECKQIMKNCYNALPVGGKLIACEPVLPKETDESHRTRALLEGDIFVMTIYRTKGKHRTEEEFIELGLSAGFPTFRPFYIDYFYTILEFQK |
Proteomic databases
Expression
Tissue specificity
Highly expressed in anthers, pistils, developing siliques, and developing seeds.
Gene expression databases
Interaction
Protein-protein interaction databases
Structure
Sequence
- Sequence statusComplete
- Length359
- Mass (Da)39,688
- Last updated2000-05-01 v1
- Checksum5847B43BF7563781
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AL132958 EMBL· GenBank· DDBJ | CAB64217.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
CP002686 EMBL· GenBank· DDBJ | AEE79041.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF367289 EMBL· GenBank· DDBJ | AAK56277.1 EMBL· GenBank· DDBJ | mRNA | ||
AY133618 EMBL· GenBank· DDBJ | AAM91448.1 EMBL· GenBank· DDBJ | mRNA |