Q9S7J9 · CAR9_ARATH

Function

function

Stimulates the GTPase/ATPase activities of Obg-like ATPases (By similarity).
Mediates the transient calcium-dependent interaction of PYR/PYL/RCAR abscisic acid (ABA) receptors with the plasma membrane and thus regulates ABA sensitivity (PubMed:25465408, PubMed:31102784).

Cofactor

Ca2+ (UniProtKB | Rhea| CHEBI:29108 )

Features

Showing features for binding site.

118520406080100120140160180
TypeIDPosition(s)Description
Binding site22Ca2+ 1 (UniProtKB | ChEBI)
Binding site23Ca2+ 1 (UniProtKB | ChEBI)
Binding site23Ca2+ 2 (UniProtKB | ChEBI)
Binding site28Ca2+ 2 (UniProtKB | ChEBI)
Binding site74Ca2+ 1 (UniProtKB | ChEBI)
Binding site74Ca2+ 2 (UniProtKB | ChEBI)
Binding site75Ca2+ 2 (UniProtKB | ChEBI)
Binding site76Ca2+ 1 (UniProtKB | ChEBI)
Binding site76Ca2+ 2 (UniProtKB | ChEBI)
Binding site82Ca2+ 1 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentnucleus
Cellular Componentplasma membrane
Molecular FunctionGTPase activator activity
Molecular Functionmetal ion binding
Molecular Functionphospholipid binding
Biological Processabscisic acid-activated signaling pathway
Biological Processpositive regulation of abscisic acid-activated signaling pathway
Biological Processpositive regulation of GTPase activity
Biological Processresponse to abscisic acid

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein C2-DOMAIN ABA-RELATED 9

Gene names

    • Name
      CAR9
    • ORF names
      F15H11.4
      , F5A18.3
    • Ordered locus names
      At1g70790

Organism names

  • Taxonomic identifier
  • Strain
    • cv. Columbia
  • Taxonomic lineage
    Eukaryota > Viridiplantae > Streptophyta > Embryophyta > Tracheophyta > Spermatophyta > Magnoliopsida > eudicotyledons > Gunneridae > Pentapetalae > rosids > malvids > Brassicales > Brassicaceae > Camelineae > Arabidopsis

Accessions

  • Primary accession
    Q9S7J9

Proteomes

Organism-specific databases

Genome annotation databases

Subcellular Location

Cell membrane
Nucleus
Note: Localization at the plasma membrane increases upon abscisic acid (ABA) treatment, at the expense of nuclear localization.

Keywords

Phenotypes & Variants

Disruption phenotype

Reduced sensitivity to abscisic acid (ABA) in single and doule mutant lot1 car9 (PubMed:31102784).
When associated with disruption in CAR1, CAR4 and CAR5 genes, altered sensitivity to ABA during seedling establishment and root growth regulation (PubMed:25465408).

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 19 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004333191-185Protein C2-DOMAIN ABA-RELATED 9

Proteomic databases

Expression

Induction

Induced by abscisic acid (ABA).

Gene expression databases

Interaction

Subunit

Binds to PYR/PYL/RCAR abscisic acid intracellular receptors in an ABA-independent manner, both at the plasma membrane and in the nucleus (By similarity).
Interacts with LOT1 in the nuleus; this interaction is repressed by abscisic acid (ABA) and is sensitive to calcium ion Ca2+, leading to free CAR9 accumulation at the plasma membrane (PubMed:31102784).

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-104C2

Sequence similarities

Belongs to the plant CAR protein family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    185
  • Mass (Da)
    21,054
  • Last updated
    2000-05-01 v1
  • Checksum
    7E2AC0D42F6D207F
MEDKPLGILRVHVKRGINLAIRDATTSDPYVVITLANQKLKTRVINNNCNPVWNEQLTLSIKDVNDPIRLTVFDKDRFSGDDKMGDAEIDFRPFLEAHQMELDFQKLPNGCAIKRIRPGRTNCLAEESSITWSNGKIMQEMILRLKNVECGEVELMLEWTDGPGCKGLGREGSKKTPWMPTKRLD

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A1P8AW00A0A1P8AW00_ARATHCAR9148

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AC008148
EMBL· GenBank· DDBJ
AAD55494.1
EMBL· GenBank· DDBJ
Genomic DNA
AC011663
EMBL· GenBank· DDBJ
AAG52327.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE35116.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
AEE35117.1
EMBL· GenBank· DDBJ
Genomic DNA
CP002684
EMBL· GenBank· DDBJ
ANM60806.1
EMBL· GenBank· DDBJ
Genomic DNA
BT026107
EMBL· GenBank· DDBJ
ABG48463.1
EMBL· GenBank· DDBJ
mRNA
AY085364
EMBL· GenBank· DDBJ
AAM62594.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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