Q9S4U0 · RRAAH_PSEFL

  • Protein
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the aldol cleavage of 4-hydroxy-4-methyl-2-oxoglutarate (HMG) into 2 molecules of pyruvate. Also contains a secondary oxaloacetate (OAA) decarboxylase activity due to the common pyruvate enolate transition state formed following C-C bond cleavage in the retro-aldol and decarboxylation reactions (By similarity).

Catalytic activity

Cofactor

a divalent metal cation (UniProtKB | Rhea| CHEBI:60240 )

Note: Divalent metal cation.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site76-79substrate
Binding site98substrate
Binding site99a divalent metal cation (UniProtKB | ChEBI)

GO annotations

AspectTerm
Molecular Function4-hydroxy-4-methyl-2-oxoglutarate aldolase activity
Molecular Functionmetal ion binding
Molecular Functionoxaloacetate decarboxylase activity
Molecular Functionribonuclease inhibitor activity
Biological Processregulation of RNA metabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase
  • EC number
  • Short names
    HMG aldolase
  • Alternative names
    • Oxaloacetate decarboxylase (OAA decarboxylase) (EC:4.1.1.112) . EC:4.1.1.112 (UniProtKB | ENZYME | Rhea)
    • Regulator of ribonuclease activity homolog
    • RraA-like protein

Organism names

  • Taxonomic identifier
  • Strain
    • OE 28.3
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Pseudomonadales > Pseudomonadaceae > Pseudomonas

Accessions

  • Primary accession
    Q9S4U0

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00002096301-163Putative 4-hydroxy-4-methyl-2-oxoglutarate aldolase

Interaction

Subunit

Homotrimer.

Structure

Family & Domains

Sequence similarities

Belongs to the class II aldolase/RraA-like family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    163
  • Mass (Da)
    17,501
  • Last updated
    2000-05-01 v1
  • Checksum
    A3963DFA9BFB6D71
MIHYVTPDLCDAYPELVQVVEPMFSNFGGRDSFGGEIVTIKCFEDNSLVKEQADQPGAGKVLVVDGGGSLRRALLGDMIAEKAAKNGWEGLVIYGCVRDVDVLAQTDLGVQALAPHPMKTDKRGIGDLNVVVTFASVTFRPGEYVYADNNGVIVSPSPLKMPE

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF115334
EMBL· GenBank· DDBJ
AAD45979.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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