Q9S469 · ARAD_GEOSE

Function

function

Involved in the degradation of L-arabinose. Catalyzes the interconversion of L-ribulose 5-phosphate (LRu5P) and D-xylulose 5-phosphate (D-Xu5P) via a retroaldol/aldol mechanism (carbon-carbon bond cleavage analogous to a class II aldolase reaction).

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate degradation; L-arabinose degradation via L-ribulose; D-xylulose 5-phosphate from L-arabinose (bacterial route): step 3/3.

Features

Showing features for binding site, active site.

Type
IDPosition(s)Description
Binding site27-28substrate
Binding site44-45substrate
Binding site73-74substrate
Binding site75Zn2+ (UniProtKB | ChEBI)
Binding site94Zn2+ (UniProtKB | ChEBI)
Binding site96Zn2+ (UniProtKB | ChEBI)
Active site119Proton donor/acceptor
Binding site168Zn2+ (UniProtKB | ChEBI)
Active site226Proton donor/acceptor

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionaldehyde-lyase activity
Molecular FunctionL-ribulose-phosphate 4-epimerase activity
Molecular Functionzinc ion binding
Biological ProcessL-arabinose catabolic process to xylulose 5-phosphate

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    L-ribulose-5-phosphate 4-epimerase
  • EC number
  • Alternative names
    • Phosphoribulose isomerase

Gene names

    • Name
      araD

Organism names

Accessions

  • Primary accession
    Q9S469

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001629171-228L-ribulose-5-phosphate 4-epimerase

Structure

Family & Domains

Sequence similarities

Belongs to the aldolase class II family. AraD/FucA subfamily.

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    228
  • Mass (Da)
    25,227
  • Last updated
    2000-05-01 v1
  • Checksum
    66EEC1746D950C84
MLEELKQAVLEANLQLPQYRLVTFTWGNVSGIDRERGLVVIKPSGVAYDKLTIDDMVVVDLTGNVVEGDLKPSSDTPTHLWLYKQFPGIGGIVHTHSTWATVWAQAGKGIPALGTTHADYFYGEIPCTRPMTNEEIQGAYELETGKVITETFRFLDPLQMPGVLVHGHGPFAWGKDPANAVHNAVVLEEVAKMAARTYMLNPNAKPISQTLLDRHYLRKHGANAYYGQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF160811
EMBL· GenBank· DDBJ
AAD45716.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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