Q9RFS6 · CYSH_BURCE

Function

function

Catalyzes the formation of sulfite from adenosine 5'-phosphosulfate (APS) using thioredoxin as an electron donor.

Catalytic activity

Cofactor

[4Fe-4S] cluster (UniProtKB | Rhea| CHEBI:49883 )

Note: Binds 1 [4Fe-4S] cluster per subunit.

Pathway

Sulfur metabolism; hydrogen sulfide biosynthesis; sulfite from sulfate.

Features

Showing features for binding site, active site.

TypeIDPosition(s)Description
Binding site119[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site120[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site202[4Fe-4S] cluster (UniProtKB | ChEBI)
Binding site205[4Fe-4S] cluster (UniProtKB | ChEBI)
Active site230Nucleophile; cysteine thiosulfonate intermediate

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Function4 iron, 4 sulfur cluster binding
Molecular Functionadenylyl-sulfate reductase (thioredoxin) activity
Molecular Functionmetal ion binding
Molecular Functionphosphoadenylyl-sulfate reductase (thioredoxin) activity
Biological Processcysteine biosynthetic process
Biological Processsulfate assimilation, phosphoadenylyl sulfate reduction by phosphoadenylyl-sulfate reductase (thioredoxin)

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Adenosine 5'-phosphosulfate reductase
  • EC number
  • Short names
    APS reductase
  • Alternative names
    • 5'-adenylylsulfate reductase
    • Thioredoxin-dependent 5'-adenylylsulfate reductase

Gene names

    • Name
      cysH

Organism names

Accessions

  • Primary accession
    Q9RFS6

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004242941-250Adenosine 5'-phosphosulfate reductase

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the PAPS reductase family. CysH subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    250
  • Mass (Da)
    27,881
  • Last updated
    2000-05-01 v1
  • Checksum
    9E0E7F8001A4A5D9
MSTATATALTPELAAKVERLDALLAQIGERHDKVKFASSLAAEDMLLTHAILSKGVPIGIFSLNTGRLHAETLGMIDRVRERYGYEIEQFHPQQDAVDRYVAEHGLNAFYESVELRKSCCHIRKVEPLNRALADVGAWVTGQRREQSVTRAELHEEEQDEARGIAKYNPLADWTEADVWAYLKAFDVPVNPLHARGYPSIGCEPCTRAIRPGEDSRAGRWWWESRDTKECGLHITTITPIPANAEAGAAH

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF170343
EMBL· GenBank· DDBJ
AAD50979.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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