Q9RA47 · Q9RA47_THETH
- ProteinMethylenetetrahydrofolate reductase
- GenemetF
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids229 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score2/5
Function
Catalytic activity
- (6S)-5-methyl-5,6,7,8-tetrahydrofolate + NAD+ = (6R)-5,10-methylene-5,6,7,8-tetrahydrofolate + NADH + H+This reaction proceeds in the backward direction.
Cofactor
Pathway
One-carbon metabolism; tetrahydrofolate interconversion.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 50 | FAD (UniProtKB | ChEBI) | |||
Binding site | 107 | FAD (UniProtKB | ChEBI) | |||
Binding site | 108 | FAD (UniProtKB | ChEBI) | |||
Binding site | 109 | FAD (UniProtKB | ChEBI) | |||
Binding site | 126 | FAD (UniProtKB | ChEBI) | |||
Binding site | 127 | FAD (UniProtKB | ChEBI) | |||
Binding site | 149 | FAD (UniProtKB | ChEBI) | |||
Binding site | 156 | FAD (UniProtKB | ChEBI) | |||
Binding site | 165 | FAD (UniProtKB | ChEBI) | |||
Binding site | 169 | FAD (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | FAD binding | |
Molecular Function | methylenetetrahydrofolate reductase (NADH) activity | |
Biological Process | methionine biosynthetic process | |
Biological Process | tetrahydrofolate interconversion |
Keywords
- Molecular function
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethylenetetrahydrofolate reductase
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus
Accessions
- Primary accessionQ9RA47
Subcellular Location
UniProt Annotation
GO Annotation
Phenotypes & Variants
Chemistry
Structure
Sequence
- Sequence statusFragment
- Length229
- Mass (Da)25,476
- Last updated2000-05-01 v1
- MD5 Checksum2AF3359A5C90B6D6D10B42375BF978A1
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Non-terminal residue | 229 | ||||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB029373 EMBL· GenBank· DDBJ | BAA88680.1 EMBL· GenBank· DDBJ | Genomic DNA |