Q9RA45 · NARK2_THETH
- ProteinProbable nitrate/nitrite antiporter NarK2
- GenenarK2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids443 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Probable nitrate/nitrite antiporter that may be involved in nitrate import and nitrite export during anaerobic growth.
Catalytic activity
- nitrate(in) + nitrite(out) = nitrate(out) + nitrite(in)This reaction proceeds in the backward direction.nitrate (in)CHEBI:17632
+ nitrite (out)CHEBI:16301= nitrate (out)CHEBI:17632+ nitrite (in)CHEBI:16301
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | plasma membrane | |
Molecular Function | antiporter activity | |
Molecular Function | nitrate transmembrane transporter activity | |
Molecular Function | nitrite transmembrane transporter activity | |
Biological Process | nitrate assimilation |
Keywords
- Biological process
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameProbable nitrate/nitrite antiporter NarK2
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Deinococcota > Deinococci > Thermales > Thermaceae > Thermus
Accessions
- Primary accessionQ9RA45
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 32-52 | Helical | ||||
Sequence: ITTFNLTLSFITWYVVSALVV | ||||||
Transmembrane | 66-86 | Helical | ||||
Sequence: LFWLTAMPGLAGGTLRIIWTF | ||||||
Transmembrane | 95-115 | Helical | ||||
Sequence: HLVTFSTLLLLIPLLGWGFAV | ||||||
Transmembrane | 123-143 | Helical | ||||
Sequence: WVLLLLAFLAGIGGGHFSGYM | ||||||
Transmembrane | 172-192 | Helical | ||||
Sequence: IVQFVTPWIIGFALFGSLLGG | ||||||
Transmembrane | 210-230 | Helical | ||||
Sequence: NATFAWVPFVLLGALLAWVYL | ||||||
Transmembrane | 256-276 | Helical | ||||
Sequence: SLYIMTFGSFSGFSAIFPLLI | ||||||
Transmembrane | 292-312 | Helical | ||||
Sequence: YAFLGPLVGSLARVIAGPISD | ||||||
Transmembrane | 314-334 | Helical | ||||
Sequence: LGGAIVTQVSAIGIFLSALLV | ||||||
Transmembrane | 346-366 | Helical | ||||
Sequence: FPMFVVAMLLIFFFSGVGNAS | ||||||
Transmembrane | 383-403 | Helical | ||||
Sequence: VIGWTAAVAAYGPFLFSTLAA | ||||||
Transmembrane | 409-429 | Helical | ||||
Sequence: TGGFTAFFYGLMVFYAFNFFL |
Keywords
- Cellular component
Phenotypes & Variants
Disruption phenotype
Mutation has minor effects on the ability to grow anaerobically. In contrast, narK1/narK2 double mutant is unable to grow anaerobically.
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000439860 | 1-443 | Probable nitrate/nitrite antiporter NarK2 | |||
Sequence: MLKSAKGTWITDWNPEDPKRWDPALAWRTLWITTFNLTLSFITWYVVSALVVRLPKVGFELSTTQLFWLTAMPGLAGGTLRIIWTFLPPILGTRHLVTFSTLLLLIPLLGWGFAVQNTGTPYWVLLLLAFLAGIGGGHFSGYMPSTSYFFPKRLQGTALGLQAGIGNFGVSIVQFVTPWIIGFALFGSLLGGPQTFTPKPGVSQPIWLQNATFAWVPFVLLGALLAWVYLRSVPIRANFREQFDIFRDKHTWIMTSLYIMTFGSFSGFSAIFPLLIREVYGKFEGAPDPLRYAFLGPLVGSLARVIAGPISDRLGGAIVTQVSAIGIFLSALLVTLYTRPTSLDQFPMFVVAMLLIFFFSGVGNASTFKQMPMIFPPRQAGGVIGWTAAVAAYGPFLFSTLAAYTQQATGGFTAFFYGLMVFYAFNFFLNWYYYARKGAEKPC |
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length443
- Mass (Da)49,070
- Last updated2012-05-16 v2
- Checksum8A9E3AC8C7006E36