Q9R803 · SCTB2_SALTY

Function

function

Component of the type III secretion system 2 (SPI-2 T3SS), also called injectisome, which is used to inject bacterial effector proteins into eukaryotic host cells (Probable). SseC/SctE2 and SseD/SctB2 are inserted into the host membrane where they form a pore and allow the translocation of effector proteins into the cytosol of target cells (Probable).
Required for the translocation of SPI-2 effector proteins (PubMed:11567004).
Required for systemic Salmonella infection of the mouse (PubMed:11159962).
Essential for SpvB-induced actin depolymerization in the host cell cytoplasm (PubMed:18248436).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular region
Cellular Componenthost cell membrane
Cellular Componentmembrane
Biological Processprotein secretion by the type III secretion system

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    SPI-2 type 3 secretion system translocon protein SctB
  • Short names
    SPI-2 T3SS translocon protein SctB
  • Alternative names
    • Secreted effector protein SseD
    • Secretion system effector D

Gene names

    • Name
      sctB2
    • Synonyms
      sseD
    • Ordered locus names
      STM1401

Organism names

Accessions

  • Primary accession
    Q9R803
  • Secondary accessions
    • O84948
    • Q7CQL8

Proteomes

Subcellular Location

Secreted
Cell surface
Host membrane
; Multi-pass membrane protein
Note: Secreted via the type III secretion system 2 (SPI-2 T3SS) (PubMed:11159962, PubMed:11567004).
After secretion, localizes mainly on the surface of the bacterial cell (PubMed:11159962, PubMed:11567004).

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane90-110Helical
Transmembrane115-135Helical
Transmembrane170-190Helical

Keywords

Phenotypes & Variants

Disruption phenotype

Disruption prevents SpvB-induced F-actin depolymerization in human macrophages without affecting intra-bacterial SpvB protein levels.

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00003917171-195SPI-2 type 3 secretion system translocon protein SctB

Proteomic databases

Interaction

Subunit

The core secretion machinery of the T3SS is composed of approximately 20 different proteins, including cytoplasmic components, a base, an export apparatus and a needle (PubMed:30107569).
This subunit is involved in the formation of a pore, called the translocon, in host membrane (Probable). May form a complex with SseB and SseC/SctE2 (PubMed:11567004).
SseB is required for correct localization of SseD/SctB2 on the bacterial cell surface (PubMed:11567004).
Binds to the chaperone SseA (PubMed:12724372, PubMed:15256549).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9R803sseA O849442EBI-2272067, EBI-2030631

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for coiled coil.

TypeIDPosition(s)Description
Coiled coil44-80

Sequence similarities

Belongs to the SctB/EspB family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    195
  • Mass (Da)
    20,592
  • Last updated
    2000-05-01 v1
  • Checksum
    45F95BBEB726D837
MEASNVALVLPAPSLLTPSSTPSPSGEGMGTESMLLLFDDIWMKLMELAKKLRDIMRSYNVEKQRLAWELQVNVLQTQMKTIDEAFRASMITAGGAMLSGVLTIGLGAVGGETGLIAGQAVGHTAGGVMGLGAGVAQRQSDQDKAIADLQQNGAQSYNKSLTEIMEKATEIMQQIIGVGSSLVTVLAEILRALTR

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict153in Ref. 2; AAC28882

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ224892
EMBL· GenBank· DDBJ
CAA12188.1
EMBL· GenBank· DDBJ
Genomic DNA
AF020808
EMBL· GenBank· DDBJ
AAC28882.1
EMBL· GenBank· DDBJ
Genomic DNA
AE006468
EMBL· GenBank· DDBJ
AAL20325.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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