Q9R381 · AAC6_SALEN

  • Protein
    Aminoglycoside N(6')-acetyltransferase type 1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Catalyzes the transfer of an acetyl group from acetyl-CoA to the 6'-amino group of aminoglycoside molecules conferring resistance to antibiotics containing the purpurosamine ring including amikacin, tobramycin, dibekacin and ribostamycin. Able to acetylate eukaryotic histone proteins.

Caution

Strain BM4361 does not express or weakly expresses aminoglycoside resistance gene and is thus aminoglycoside-sensitive. Strain BM4362 expresses it due to a chromosomal deletion leading to aminoglycoside resistance.

Catalytic activity

Features

Showing features for binding site.

114520406080100120140
TypeIDPosition(s)Description
Binding site22substrate
Binding site25substrate
Binding site66substrate
Binding site79substrate
Binding site81-83acetyl-CoA (UniProtKB | ChEBI)
Binding site89-94acetyl-CoA (UniProtKB | ChEBI)
Binding site115substrate
Binding site120acetyl-CoA (UniProtKB | ChEBI)
Binding site136substrate

GO annotations

AspectTerm
Molecular Functionaminoglycoside 6'-N-acetyltransferase activity
Molecular Functionprotein homodimerization activity
Biological Processacetyl-CoA metabolic process
Biological Processresponse to antibiotic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Aminoglycoside N(6')-acetyltransferase type 1
  • EC number
  • Alternative names
    • AAC(6')-Iy
    • Aminoglycoside resistance protein

Organism names

  • Taxonomic identifier
  • Strains
    • BM4361
    • BM4362
  • Taxonomic lineage
    Bacteria > Pseudomonadota > Gammaproteobacteria > Enterobacterales > Enterobacteriaceae > Salmonella

Accessions

  • Primary accession
    Q9R381

Phenotypes & Variants

Chemistry

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004168291-145Aminoglycoside N(6')-acetyltransferase type 1

Interaction

Subunit

Homodimer.

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain1-145N-acetyltransferase

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    145
  • Mass (Da)
    16,362
  • Last updated
    2000-05-01 v1
  • Checksum
    9CD8BBFD48BC43A2
MDIRQMNKTHLEHWRGLRKQLWPGHPDDAHLADGEEILQADHLASFIAMADGVAIGFADASIRHDYVNGCDSSPVVFLEGIFVLPSFRQRGVAKQLIAAVQRWGTNKGCREMASDTSPENTISQKVHQALGFEETERVIFYRKRC

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF144880
EMBL· GenBank· DDBJ
AAF03531.1
EMBL· GenBank· DDBJ
Genomic DNA
AF144881
EMBL· GenBank· DDBJ
AAF03532.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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