Q9R1Z0 · VDAC3_RAT
- ProteinNon-selective voltage-gated ion channel VDAC3
- GeneVdac3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids283 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Non-selective voltage-gated ion channel that mediates the transport of anions and cations through the mitochondrion outer membrane and plasma membrane. Forms a high-conducting channel with a stable open state and a voltage-induced closure with a mild preference for anions over cations (By similarity).
Involved in male fertility and sperm mitochondrial sheath formation (By similarity).
Involved in male fertility and sperm mitochondrial sheath formation (By similarity).
Catalytic activity
- chloride(in) = chloride(out)
- K+(in) = K+(out)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 242-244 | NAD+ (UniProtKB | ChEBI) | |||
Binding site | 260-264 | NAD+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | membrane | |
Cellular Component | mitochondrial outer membrane | |
Cellular Component | mitochondrion | |
Cellular Component | pore complex | |
Cellular Component | synaptic vesicle | |
Molecular Function | nucleotide binding | |
Molecular Function | porin activity | |
Molecular Function | voltage-gated monoatomic anion channel activity | |
Biological Process | behavioral fear response | |
Biological Process | chemical synaptic transmission | |
Biological Process | learning | |
Biological Process | neuron-neuron synaptic transmission | |
Biological Process | sperm mitochondrial sheath assembly | |
Biological Process | spermatogenesis |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameNon-selective voltage-gated ion channel VDAC3
- Short namesVDAC-3; rVDAC3
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9R1Z0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Note: May localize to non-mitochondrial membranes.
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Transmembrane | 26-35 | Beta stranded | |||
Transmembrane | 39-47 | Beta stranded | |||
Transmembrane | 54-64 | Beta stranded | |||
Transmembrane | 69-76 | Beta stranded | |||
Transmembrane | 80-89 | Beta stranded | |||
Transmembrane | 95-104 | Beta stranded | |||
Transmembrane | 111-120 | Beta stranded | |||
Transmembrane | 123-130 | Beta stranded | |||
Transmembrane | 137-145 | Beta stranded | |||
Transmembrane | 150-158 | Beta stranded | |||
Transmembrane | 163-175 | Beta stranded | |||
Transmembrane | 178-185 | Beta stranded | |||
Transmembrane | 189-198 | Beta stranded | |||
Transmembrane | 202-211 | Beta stranded | |||
Transmembrane | 218-227 | Beta stranded | |||
Transmembrane | 231-238 | Beta stranded | |||
Transmembrane | 242-251 | Beta stranded | |||
Transmembrane | 254-263 | Beta stranded | |||
Transmembrane | 273-282 | Beta stranded | |||
Keywords
- Cellular component
PTM/Processing
Features
Showing features for initiator methionine, modified residue, chain, cross-link.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Initiator methionine | 1 | Removed | |||
Modified residue | 2 | N-acetylcysteine | |||
Chain | PRO_0000050517 | 2-283 | Non-selective voltage-gated ion channel VDAC3 | ||
Modified residue | 4 | Phosphothreonine | |||
Modified residue | 12 | N6-acetyllysine | |||
Modified residue | 15 | N6-acetyllysine | |||
Modified residue | 20 | N6-acetyllysine | |||
Modified residue | 33 | Phosphothreonine | |||
Cross-link | 53 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Modified residue | 90 | N6-acetyllysine | |||
Cross-link | 109 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Cross-link | 110 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin) | |||
Modified residue | 241 | Phosphoserine | |||
Modified residue | 266 | N6-acetyllysine; alternate | |||
Cross-link | 266 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin); alternate | |||
Post-translational modification
Ubiquitinated by PRKN during mitophagy, leading to its degradation and enhancement of mitophagy. Deubiquitinated by USP30.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Isoform 1 is widely expressed with strong expression in atrium and ascitic tumor, lower levels in brain and very low levels in liver and kidney (PubMed:10998068).
Isoform 2 is also widely expressed with highest levels in brain but no expression in kidney (PubMed:10998068).
Also expressed in flagella of epididymal sperm (PubMed:19423663).
Isoform 2 is also widely expressed with highest levels in brain but no expression in kidney (PubMed:10998068).
Also expressed in flagella of epididymal sperm (PubMed:19423663).
Structure
Family & Domains
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9R1Z0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- SynonymsRVDAC3
- Length283
- Mass (Da)30,798
- Last updated2001-08-14 v2
- MD5 ChecksumA4D77A645312676C2573E9D3C93CC9F7
Q9R1Z0-2
- Name2
- SynonymsRVDAC3V
- Differences from canonical
- 39-39: V → VM
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A0G2JSR0 | A0A0G2JSR0_RAT | Vdac3 | 284 | ||
A0A8I6AE64 | A0A8I6AE64_RAT | Vdac3 | 258 | ||
A0A8I6G8C8 | A0A8I6G8C8_RAT | Vdac3 | 264 |
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Alternative sequence | VSP_005080 | 39 | in isoform 2 | ||
Sequence conflict | 128 | in Ref. 2; AAF80117 and 3; AAH61780 | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB039664 EMBL· GenBank· DDBJ | BAB13475.1 EMBL· GenBank· DDBJ | mRNA | ||
AF268469 EMBL· GenBank· DDBJ | AAF80117.1 EMBL· GenBank· DDBJ | mRNA | ||
BC061780 EMBL· GenBank· DDBJ | AAH61780.1 EMBL· GenBank· DDBJ | mRNA | ||
AF048829 EMBL· GenBank· DDBJ | AAD22722.1 EMBL· GenBank· DDBJ | mRNA | ||
AF048830 EMBL· GenBank· DDBJ | AAD22723.1 EMBL· GenBank· DDBJ | mRNA |