Q9R1S3 · PIGN_MOUSE

  • Protein
    GPI ethanolamine phosphate transferase 1
  • Gene
    Pign
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Ethanolamine phosphate transferase involved in glycosylphosphatidylinositol-anchor biosynthesis. Transfers ethanolamine phosphate to the first alpha-1,4-linked mannose of the glycosylphosphatidylinositol precursor of GPI-anchor. May act as suppressor of replication stress and chromosome missegregation.

Miscellaneous

Target of the inhibitor of GPI biosynthesis YW3548/BE49385A.

Pathway

Glycolipid biosynthesis; glycosylphosphatidylinositol-anchor biosynthesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentendoplasmic reticulum membrane
Molecular Functionmannose-ethanolamine phosphotransferase activity
Molecular Functionphosphotransferase activity, for other substituted phosphate groups
Biological ProcessGPI anchor biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    GPI ethanolamine phosphate transferase 1
  • EC number
  • Alternative names
    • Phosphatidylinositol-glycan biosynthesis class N protein (PIG-N)

Gene names

    • Name
      Pign

Organism names

  • Taxonomic identifier
  • Strains
    • C57BL/6J
    • FVB/N
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9R1S3
  • Secondary accessions
    • Q3V0S6
    • Q8VCC3
    • Q9R1S1
    • Q9R1S2

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

Type
IDPosition(s)Description
Topological domain1Cytoplasmic
Transmembrane2-22Helical
Topological domain23-442Lumenal
Transmembrane443-463Helical
Topological domain464-480Cytoplasmic
Transmembrane481-501Helical
Topological domain502Lumenal
Transmembrane503-523Helical
Topological domain524-543Cytoplasmic
Transmembrane544-564Helical
Topological domain565Lumenal
Transmembrane566-586Helical
Topological domain587-591Cytoplasmic
Transmembrane592-612Helical
Topological domain613-618Lumenal
Transmembrane619-639Helical
Topological domain640-649Cytoplasmic
Transmembrane650-670Helical
Topological domain671-685Lumenal
Transmembrane686-706Helical
Topological domain707-723Cytoplasmic
Transmembrane724-744Helical
Topological domain745-786Lumenal
Transmembrane787-807Helical
Topological domain808-824Cytoplasmic
Transmembrane825-845Helical
Topological domain846-858Lumenal
Transmembrane859-879Helical
Topological domain880-894Cytoplasmic
Transmembrane895-915Helical
Topological domain916-931Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation.

Type
IDPosition(s)Description
ChainPRO_00002461991-931GPI ethanolamine phosphate transferase 1
Glycosylation128N-linked (GlcNAc...) asparagine
Glycosylation192N-linked (GlcNAc...) asparagine
Glycosylation295N-linked (GlcNAc...) asparagine
Glycosylation350N-linked (GlcNAc...) asparagine
Glycosylation616N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Interaction

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Belongs to the PIGG/PIGN/PIGO family. PIGN subfamily.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q9R1S3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    931
  • Mass (Da)
    105,045
  • Last updated
    2006-07-25 v2
  • Checksum
    75637C514E8D3AF4
MLLFFALGLLIHFVFFASIFDIYFTSPLVHGMTPQFTPLPPPAKRLVLFVADGLRADTLYELDEDGNSRAPFIRNVIIHEGSWGVSHTRVPTESRPGHVALIAGFYEDVSAVAKGWKENPVEFDSLFNESKYTWSWGSPDILPMFAKGASGDHVYTYSYDAQREDFGAHDATKLDTWVFDKVKDFFDAARNNQSLFTKVNEEKVVFFLHLLGIDTNGHAHRPSSREYKDNIKKVDDGVKEIVSIFKHFYGDDGKTAFIFTSDHGMTDWGSHGAGHPSETLTPFVTWGAGIKFPQNVSAQQYDDEFLKEWRLENWKRRDVNQADIAPLMASLIGVPFPLNSVGILPVGYLNNTGLFKAESMFTNAVQILEQFKVKMTQKKEATLPFLFTPFKLLSDSQQLDILRKARSYIKQEKFDEVVSLCEELIDLALRGLSYYHTYDRLFLGINVAVGFVGWMSYTSLLIIKSHSNIPKGTRKEGKKPHCLLLYSFIATGVLVACFLMIQACPWTYYVYCLLPVPIWYAVLREHEVIQDLVESLLTFPRSHFVAYLLVFTLGIEVLVLSFFYRYMLTAGLIVFAGWPFLTQLWTRAKITFLSWAFFSLLLAVFPLMPVVGRKPNLSLVMGAGFLVLLLSLAVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVYSTHHSLLKKEGLPLMNQIVSWATLASSLVAPLLSSTALSQRLASILLSLMSTYLLLSTGYEALFPLVLSCLMFVWIQVEQETLQQPGVSCKQKLTSIQFTCDTDIAQFRQLCPDDIRRAFFLVFFLLTAFFGTGNIASINSFDLASVYCFLTVFSPFMMGALMMWKILIPFVLVMCAFEAVQITTQLSSKGLFLVVLIISDIMALHFFFLVKDSGSWLDIGTSISHYVIVMSMTIFLVFLNGLAQLLTTKKLQLCGKPKSHLM

Q9R1S3-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9R1S3-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 791-826: VFFLLTAFFGTGNIASINSFDLASVYCFLTVFSPFM → ILLIFPVFLRLFDYKRIRILLAQENYHRSLKAAWEL
    • 827-931: Missing

Q9R1S3-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-602: Missing
    • 603-692: AVFPLMPVVGRKPNLSLVMGAGFLVLLLSLAVVTTLGKRNIKLVKGELLVLLLQMLSTVLSMYVVYSTHHSLLKKEGLPLMNQIVSWATL → MVLFISITCLYVFSSFSVRTSTCLIVFSCFSLRTCNSLAVFSCISLSDLLKSFLMSSIIIMRYAFKSRSRFSGVLGCPGLGEVGVLGSDD

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A087WNT9A0A087WNT9_MOUSEPign74
A0A087WQ32A0A087WQ32_MOUSEPign826
A0A087WS03A0A087WS03_MOUSEPign798
G3X9F1G3X9F1_MOUSEPign931

Features

Showing features for alternative sequence, sequence conflict.

Type
IDPosition(s)Description
Alternative sequenceVSP_0198341-602in isoform 4
Sequence conflict17in Ref. 1; BAA82619/BAA82620
Sequence conflict78in Ref. 1; BAA82619/BAA82620/BAA82663
Sequence conflict213in Ref. 1; BAA82619/BAA82620
Alternative sequenceVSP_019835603-692in isoform 4
Alternative sequenceVSP_019837791-798in isoform 2
Alternative sequenceVSP_019836791-826in isoform 3
Alternative sequenceVSP_019838799-931in isoform 2
Alternative sequenceVSP_019839827-931in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB030279
EMBL· GenBank· DDBJ
BAA82619.1
EMBL· GenBank· DDBJ
mRNA
AB030280
EMBL· GenBank· DDBJ
BAA82620.1
EMBL· GenBank· DDBJ
mRNA
AB030316
EMBL· GenBank· DDBJ
BAA82663.1
EMBL· GenBank· DDBJ
Genomic DNA
AK132928
EMBL· GenBank· DDBJ
BAE21427.1
EMBL· GenBank· DDBJ
mRNA
BC021148
EMBL· GenBank· DDBJ
AAH21148.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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