Q9R0X6 · Q9R0X6_MOUSE
- ProteinTransporter
- GeneSlc6a3
- StatusUniProtKB unreviewed (TrEMBL)
- Organism
- Amino acids619 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score3/5
Function
Catalytic activity
- (R)-noradrenaline(out) + chloride(out) + Na+(out) = (R)-noradrenaline(in) + chloride(in) + Na+(in)(R)-noradrenaline (out)CHEBI:72587
+ chloride (out)CHEBI:17996+ Na+ (out)CHEBI:29101= (R)-noradrenaline (in)CHEBI:72587+ chloride (in)CHEBI:17996+ Na+ (in)CHEBI:29101 - chloride(out) + dopamine(out) + 2 Na+(out) = chloride(in) + dopamine(in) + 2 Na+(in)
- chloride(out) + dopamine(out) + Na+(out) = chloride(in) + dopamine(in) + Na+(in)
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 75 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: G | ||||||
Binding site | 77 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: A | ||||||
Binding site | 78 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: V | ||||||
Binding site | 82 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 320 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 352 | Na+ 2 (UniProtKB | ChEBI) | ||||
Sequence: N | ||||||
Binding site | 417 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: L | ||||||
Binding site | 420 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 421 | Na+ 1 (UniProtKB | ChEBI) | ||||
Sequence: S |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | axon | |
Cellular Component | neuronal cell body membrane | |
Cellular Component | presynaptic membrane | |
Molecular Function | dopamine:sodium symporter activity | |
Molecular Function | metal ion binding | |
Molecular Function | norepinephrine:sodium symporter activity | |
Biological Process | dopamine uptake involved in synaptic transmission |
Keywords
- Biological process
- Ligand
Names & Taxonomy
Protein names
- Recommended nameTransporter
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9R0X6
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Membrane ; Multi-pass membrane protein
Features
Showing features for transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Transmembrane | 69-87 | Helical | ||||
Sequence: FLLSVIGFAVDLANVWRFP | ||||||
Transmembrane | 99-120 | Helical | ||||
Sequence: LVPYLLFMVIAGMPLFYMELAL | ||||||
Transmembrane | 141-168 | Helical | ||||
Sequence: VGFTVILISFYVGFFYNVIIAWALHYFF | ||||||
Transmembrane | 237-254 | Helical | ||||
Sequence: WQLTACLVLVIVLLYFSL | ||||||
Transmembrane | 266-289 | Helical | ||||
Sequence: WITATMPYVVLTALLLRGVTLPGA | ||||||
Transmembrane | 309-331 | Helical | ||||
Sequence: VWIDAATQVCFSLGVGFGVLIAF | ||||||
Transmembrane | 351-371 | Helical | ||||
Sequence: INSLTSFSSGFVVFSFLGYMA | ||||||
Transmembrane | 391-417 | Helical | ||||
Sequence: IIYPEAIATLPLSSAWAAVFFLMLLTL | ||||||
Transmembrane | 446-471 | Helical | ||||
Sequence: LFTLGIVLATFLLSLFCVANGGIYVF | ||||||
Transmembrane | 477-500 | Helical | ||||
Sequence: FAAGTSILFGVLIEAIGVAWFYGV | ||||||
Transmembrane | 521-543 | Helical | ||||
Sequence: LCWKLVSPCFLLYVVVVSIVTFR | ||||||
Transmembrane | 555-577 | Helical | ||||
Sequence: WANALGWIIATSSMAMVPIYATY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Disulfide bond | 180↔189 | |||||
Sequence: CNNTWNSPNC |
Keywords
- PTM
Structure
Family & Domains
Sequence similarities
Keywords
- Domain
Family and domain databases
Sequence
- Sequence statusComplete
- Length619
- Mass (Da)68,775
- Last updated2000-05-01 v1
- ChecksumF42BA5A959CC3FDE