Q9R0M1 · XCR1_MOUSE
- ProteinChemokine XC receptor 1
- GeneXcr1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids322 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Receptor for chemokines SCYC1 and SCYC2. Subsequently transduces a signal by increasing the intracellular calcium ions level. Receptor for XCL1/Lymphotactin (Probable).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | external side of plasma membrane | |
Molecular Function | C-C chemokine binding | |
Molecular Function | C-C chemokine receptor activity | |
Biological Process | calcium-mediated signaling | |
Biological Process | cell chemotaxis | |
Biological Process | chemotaxis | |
Biological Process | immune response | |
Biological Process | positive regulation of cytosolic calcium ion concentration | |
Biological Process | release of sequestered calcium ion into cytosol | |
Biological Process | response to cytokine |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameChemokine XC receptor 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9R0M1
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 1-27 | Extracellular | ||||
Sequence: MESSTAFYDYHDKLSLLCENNVIFFST | ||||||
Transmembrane | 28-55 | Helical; Name=1 | ||||
Sequence: ISTIVLYSLVFLLSLVGNSLVLWVLVKY | ||||||
Topological domain | 56-65 | Cytoplasmic | ||||
Sequence: ENLESLTNIF | ||||||
Transmembrane | 66-85 | Helical; Name=2 | ||||
Sequence: ILNLCLSDLMFSCLLPVLIS | ||||||
Topological domain | 86-98 | Extracellular | ||||
Sequence: AQWSWFLGDFFCK | ||||||
Transmembrane | 99-120 | Helical; Name=3 | ||||
Sequence: FFNMIFGISLYSSIFFLTIMTI | ||||||
Topological domain | 121-137 | Cytoplasmic | ||||
Sequence: HRYLSVVSPISTLGIHT | ||||||
Transmembrane | 138-162 | Helical; Name=4 | ||||
Sequence: LRCRVLVTSCVWAASILFSIPDAVF | ||||||
Topological domain | 163-185 | Extracellular | ||||
Sequence: HKVISLNCKYSEHHGFLASVYQH | ||||||
Transmembrane | 186-204 | Helical; Name=5 | ||||
Sequence: NIFFLLSMGIILFCYVQIL | ||||||
Topological domain | 205-220 | Cytoplasmic | ||||
Sequence: RTLFRTRSRQRHRTVR | ||||||
Transmembrane | 221-243 | Helical; Name=6 | ||||
Sequence: LIFTVVVAYFLSWAPYNLTLFLK | ||||||
Topological domain | 244-259 | Extracellular | ||||
Sequence: TGIIQQSCESLQQLDI | ||||||
Transmembrane | 260-283 | Helical; Name=7 | ||||
Sequence: AMIICRHLAFSHCCFNPVLYVFVG | ||||||
Topological domain | 284-322 | Cytoplasmic | ||||
Sequence: IKFRRHLKHLFQQVWLCRKTSSTVPCSPGTFTYEGPSFY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000070222 | 1-322 | Chemokine XC receptor 1 | |||
Sequence: MESSTAFYDYHDKLSLLCENNVIFFSTISTIVLYSLVFLLSLVGNSLVLWVLVKYENLESLTNIFILNLCLSDLMFSCLLPVLISAQWSWFLGDFFCKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPISTLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVISLNCKYSEHHGFLASVYQHNIFFLLSMGIILFCYVQILRTLFRTRSRQRHRTVRLIFTVVVAYFLSWAPYNLTLFLKTGIIQQSCESLQQLDIAMIICRHLAFSHCCFNPVLYVFVGIKFRRHLKHLFQQVWLCRKTSSTVPCSPGTFTYEGPSFY | ||||||
Disulfide bond | 97↔170 | |||||
Sequence: CKFFNMIFGISLYSSIFFLTIMTIHRYLSVVSPISTLGIHTLRCRVLVTSCVWAASILFSIPDAVFHKVISLNC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed by dendritic cells from the thymus, slpeen, subcutaneous lymph nodes and mesenteric lymph nodes.
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Length322
- Mass (Da)37,308
- Last updated2000-05-01 v1
- Checksum89A5573BD97A1CA3
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB028459 EMBL· GenBank· DDBJ | BAA85419.1 EMBL· GenBank· DDBJ | Genomic DNA |