Q9QZT0 · CUZD1_RAT
- ProteinCUB and zona pellucida-like domain-containing protein 1
- GeneCuzd1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids607 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Localized to zymogen granules, where it functions in trypsinogen activation (By similarity).
May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | cell surface | |
Cellular Component | extracellular space | |
Cellular Component | membrane | |
Cellular Component | zymogen granule | |
Cellular Component | zymogen granule membrane | |
Biological Process | female pregnancy | |
Biological Process | hormone-mediated signaling pathway | |
Biological Process | trypsinogen activation |
Names & Taxonomy
Protein names
- Recommended nameCUB and zona pellucida-like domain-containing protein 1
- Short namesCUB and ZP domain-containing protein 1
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9QZT0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Zymogen granule membrane ; Single-pass type I membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 20-568 | Lumenal | ||||
Sequence: QLNSTAAEGRPRCTASLGGANLGETHKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPLLGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFSSGTTIPNCGGYLQTLEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGPSTTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYASTYVQEVNTHSLSCASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDHTISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGKYNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDHTSRCNQGCVSRRKRDIPSYKWKTDSVIGPIRLKRDRLVNGDSGLLPQTHEAEISKQPLSH | ||||||
Transmembrane | 569-589 | Helical | ||||
Sequence: LHLFSFMVLALNVVIVVTATV | ||||||
Topological domain | 590-607 | Cytoplasmic | ||||
Sequence: RHFLNRWKDHGYQKLQVY |
Keywords
- Cellular component
PTM/Processing
Features
Showing features for signal, chain, glycosylation, disulfide bond.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-19 | |||||
Sequence: MEVTGRLFIWAILAVSCRA | ||||||
Chain | PRO_0000233333 | 20-607 | CUB and zona pellucida-like domain-containing protein 1 | |||
Sequence: QLNSTAAEGRPRCTASLGGANLGETHKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPLLGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFSSGTTIPNCGGYLQTLEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGPSTTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYASTYVQEVNTHSLSCASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDHTISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGKYNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDHTSRCNQGCVSRRKRDIPSYKWKTDSVIGPIRLKRDRLVNGDSGLLPQTHEAEISKQPLSHLHLFSFMVLALNVVIVVTATVRHFLNRWKDHGYQKLQVY | ||||||
Glycosylation | 22 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 32↔58 | |||||
Sequence: CTASLGGANLGETHKALILNLNADENC | ||||||
Glycosylation | 67 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 85↔107 | |||||
Sequence: CENESIKVFDGRSTSGPLLGEAC | ||||||
Disulfide bond | 154↔180 | |||||
Sequence: CGGYLQTLEGSFSSPNYPRPHPELAYC | ||||||
Glycosylation | 195 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 207↔229 | |||||
Sequence: CRFDFIAVYDGPSTTSGLLKQVC | ||||||
Glycosylation | 419 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 442↔498 | |||||
Sequence: CRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed predominantly in epithelium of uterus and oviduct.
Induction
By estrogen, tamoxifen and growth hormone. Repressed by progesterone and by the antiestrogen ICI 182780.
Developmental stage
In uterus, strongly expressed at proestrus, declines at estrus and disappears at diestrus. In oviduct, strongly expressed at both proestrus and estrus but declines significantly at diestrus. In uterus, highly expressed on day 1 of pregnancy but declines dramatically on day 2 and is not detected between days 3 and 7. In oviduct, highly expressed on days 1 and 2 of pregnancy but declines significantly on days 3 and 4.
Interaction
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 32-146 | CUB 1 | ||||
Sequence: CTASLGGANLGETHKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPLLGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFS | ||||||
Domain | 154-265 | CUB 2 | ||||
Sequence: CGGYLQTLEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGPSTTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYAST | ||||||
Domain | 276-519 | ZP | ||||
Sequence: SCASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDHTISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGKYNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDHTSRCNQGCVSR |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length607
- Mass (Da)68,640
- Last updated2006-05-02 v2
- Checksum68B59BCD31322012
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
F1M8L3 | F1M8L3_RAT | Cuzd1 | 607 |
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Sequence conflict | 35 | in Ref. 1; AAD55939 | ||||
Sequence: S → M | ||||||
Sequence conflict | 273 | in Ref. 3; AAH90345 | ||||
Sequence: H → T | ||||||
Sequence conflict | 469 | in Ref. 3; AAH90345 | ||||
Sequence: E → K |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF167170 EMBL· GenBank· DDBJ | AAD55939.1 EMBL· GenBank· DDBJ | mRNA | ||
AF022147 EMBL· GenBank· DDBJ | AAB71895.1 EMBL· GenBank· DDBJ | mRNA | ||
BC090345 EMBL· GenBank· DDBJ | AAH90345.1 EMBL· GenBank· DDBJ | mRNA |