Q9QZT0 · CUZD1_RAT

  • Protein
    CUB and zona pellucida-like domain-containing protein 1
  • Gene
    Cuzd1
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    4/5

Function

function

Localized to zymogen granules, where it functions in trypsinogen activation (By similarity).
May indirectly regulate cell motility, cell-cell and cell/extracellular matrix interactions (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentextracellular space
Cellular Componentmembrane
Cellular Componentzymogen granule
Cellular Componentzymogen granule membrane
Biological Processfemale pregnancy
Biological Processhormone-mediated signaling pathway
Biological Processtrypsinogen activation

Names & Taxonomy

Protein names

  • Recommended name
    CUB and zona pellucida-like domain-containing protein 1
  • Short names
    CUB and ZP domain-containing protein 1
  • Alternative names
    • Estrogen-regulated protein 1
    • Uterus/ovary-specific protein 44

Gene names

    • Name
      Cuzd1
    • Synonyms
      Erg1

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9QZT0
  • Secondary accessions
    • O35360
    • Q5D000

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain20-568Lumenal
Transmembrane569-589Helical
Topological domain590-607Cytoplasmic

Keywords

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-19
ChainPRO_000023333320-607CUB and zona pellucida-like domain-containing protein 1
Glycosylation22N-linked (GlcNAc...) asparagine
Disulfide bond32↔58
Glycosylation67N-linked (GlcNAc...) asparagine
Disulfide bond85↔107
Disulfide bond154↔180
Glycosylation195N-linked (GlcNAc...) asparagine
Disulfide bond207↔229
Glycosylation419N-linked (GlcNAc...) asparagine
Disulfide bond442↔498

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed predominantly in epithelium of uterus and oviduct.

Induction

By estrogen, tamoxifen and growth hormone. Repressed by progesterone and by the antiestrogen ICI 182780.

Developmental stage

In uterus, strongly expressed at proestrus, declines at estrus and disappears at diestrus. In oviduct, strongly expressed at both proestrus and estrus but declines significantly at diestrus. In uterus, highly expressed on day 1 of pregnancy but declines dramatically on day 2 and is not detected between days 3 and 7. In oviduct, highly expressed on days 1 and 2 of pregnancy but declines significantly on days 3 and 4.

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain32-146CUB 1
Domain154-265CUB 2
Domain276-519ZP

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    607
  • Mass (Da)
    68,640
  • Last updated
    2006-05-02 v2
  • Checksum
    68B59BCD31322012
MEVTGRLFIWAILAVSCRAQLNSTAAEGRPRCTASLGGANLGETHKALILNLNADENCTWTIERPENRSIRIIFSHIQLDPDSRCENESIKVFDGRSTSGPLLGEACSKNDFVPVFESSANSLTFQIVTDWTRVQRSVFIFYYFFSSGTTIPNCGGYLQTLEGSFSSPNYPRPHPELAYCVWHIQVEKGYKINLNFTELFLEMDEYCRFDFIAVYDGPSTTSGLLKQVCGRGTPTFESSSDAMTVVLSTDYANSYRGFFASYASTYVQEVNTHSLSCASDKMRVIISKSYLQSLNYHESNLQLNDPTCRPSVSNVVEFSIPLHECGTIKKIEDHTISYTNIITFTQSPESAVITRKRHLQIVVTCEMEYNSTVEILYITEDDVIQNQSVLGKYNTSMALYESGSFENLIQESPYYVDLNQTLFVQATLHTSDPSLVVFLDTCRASPTSDFASPTYDLISSGCSRDETCEVYPLFGHYGRFQFNAFKFLRHLSSVYLKCKILICDTSDHTSRCNQGCVSRRKRDIPSYKWKTDSVIGPIRLKRDRLVNGDSGLLPQTHEAEISKQPLSHLHLFSFMVLALNVVIVVTATVRHFLNRWKDHGYQKLQVY

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
F1M8L3F1M8L3_RATCuzd1607

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict35in Ref. 1; AAD55939
Sequence conflict273in Ref. 3; AAH90345
Sequence conflict469in Ref. 3; AAH90345

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF167170
EMBL· GenBank· DDBJ
AAD55939.1
EMBL· GenBank· DDBJ
mRNA
AF022147
EMBL· GenBank· DDBJ
AAB71895.1
EMBL· GenBank· DDBJ
mRNA
BC090345
EMBL· GenBank· DDBJ
AAH90345.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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