Q9QZR8 · PDZD2_RAT

  • Protein
    PDZ domain-containing protein 2
  • Gene
    Pdzd2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

Features

Showing features for site.

127662004006008001,0001,2001,4001,6001,8002,0002,2002,4002,600
TypeIDPosition(s)Description
Site2402-2403Cleavage; by caspases

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentapical part of cell
Cellular Componentcell-cell junction
Cellular Componentcytoplasm
Cellular Componentendoplasmic reticulum
Cellular Componentextracellular region
Cellular Componentnucleus
Biological Processcell adhesion
Biological Processintracellular signal transduction

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    PDZ domain-containing protein 2
  • Alternative names
    • PDZ domain-containing protein 3
    • Plakophilin-related armadillo repeat protein-interacting PDZ protein

Gene names

    • Name
      Pdzd2
    • Synonyms
      Papin, Pdzk3, Pin1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9QZR8

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Cytoplasm
Endoplasmic reticulum
Cell junction
Note: At cell-cell contacts in lung epithelial cells (PubMed:10896674).

Processed PDZ domain-containing protein 2

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis2402Loss of proteolytic cleavage.
Mutagenesis2402-2411Loss of proteolytic cleavage.
Mutagenesis2404No loss of proteolytic cleavage.

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000582951-2766PDZ domain-containing protein 2
Modified residue517Phosphoserine
Modified residue891Phosphoserine
Modified residue895Phosphoserine
Modified residue1767Phosphoserine
ChainPRO_0000302757?2403-2766Processed PDZ domain-containing protein 2

Post-translational modification

A secreted form is produced by caspase-mediated proteolytic cleavage.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in the heart, liver, brain, spleen, lung, kidney, testis and skeletal muscle.

Interaction

Subunit

Interacts with SCN10A, CTNND2 and PKP4.

Protein-protein interaction databases

Structure

3D structure databases

Family & Domains

Features

Showing features for domain, compositional bias, region.

TypeIDPosition(s)Description
Domain85-177PDZ 1
Compositional bias189-207Polar residues
Region189-315Disordered
Compositional bias227-245Polar residues
Compositional bias276-315Basic and acidic residues
Domain334-419PDZ 2
Region419-452Disordered
Compositional bias423-450Polar residues
Domain535-621PDZ 3
Compositional bias627-653Polar residues
Region627-673Disordered
Domain679-764PDZ 4
Compositional bias783-798Polar residues
Region783-803Disordered
Region834-853Disordered
Region915-966Disordered
Region990-1425Disordered
Compositional bias1033-1060Polar residues
Compositional bias1126-1140Polar residues
Compositional bias1190-1225Polar residues
Compositional bias1271-1288Polar residues
Compositional bias1320-1346Polar residues
Compositional bias1381-1423Polar residues
Compositional bias1456-1481Polar residues
Region1456-1531Disordered
Region1725-1909Disordered
Compositional bias1846-1860Basic and acidic residues
Compositional bias1880-1908Polar residues
Region1924-1967Disordered
Region2015-2070Disordered
Compositional bias2056-2070Polar residues
Region2146-2174Disordered
Compositional bias2262-2350Polar residues
Region2262-2397Disordered
Compositional bias2360-2394Polar residues
Region2424-2450Disordered
Compositional bias2428-2442Polar residues
Compositional bias2465-2479Polar residues
Region2465-2496Disordered
Domain2550-2634PDZ 5
Region2635-2667Disordered
Domain2678-2763PDZ 6

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    2,766
  • Mass (Da)
    293,890
  • Last updated
    2000-05-01 v1
  • Checksum
    1DC34DF7B4A6D1DD
MPITQDNALLHLPLLYEWLQNSLREGGDSPEQRLCQAAIQKLQEYIQLNLAVDESTVPPDHSPPEMEICTVYLTKQLGDTETVGLSFGNIPVFGDYGEKRRGGKKRKTHQGPVLDVGCIWVTELRKNSPAGKSGKVRLRDEILSLNGQLMVGVDVTGASYLAEQCWNGGFIYLIMLRRFKQKAHVTYNGNSGNSSEPGETPTLELGDQTSKKGKRTRKFGVISRPSISKTPEDSKSSSGCDTADDPNSELENGADPELGNGHAFELENGPHSLKDVAGPHLERSEADSEVELRVPKTEAPLSDSNDKRRFSKTGKTDFQSSDCLAREEVGRIWKMELLKESDGLGIQVSGGRGSKRSPHAIVVTQVKEGGAAHRDGRLSLGDELLVINGHLLVGLSHEEAVAILRSATGMVQLVVASKMPGSEESQDVGSSEESKGNLESPKQGNCKTKLKSRLSGGVHRLESVEEYNELMVRNGDPRIRMLEVSRDGRKHSLPQLLDSTGTSQEYHIVKKSTRSLSTTHVESPWRLIRPSVISIIGLYKEKGKGLGFSIAGGRDCIRGQMGIFVKTIFPNGSAAEDGRLKEGDEILDVNGIPIKGLTFQEAIHTFKQIRSGLFVLTVRTKLLSPSLTPCSTPTHMSRSSSPSFNTNSGGTPAGGGQEEGGSSSLGRKAPGPKDRIVMEVTLNKEPRVGLGIGACCLALENSPPGIYIHSLAPGSVAKMESNLSRGDQILEVNSVNVRHAALSKVHAILSKCPPGPVRLVIGRHPNPKVSEQEMDEVIARSTYQESREANSSPGLGTPLKSPSLAKKDSLLSESELSQYFVHDGQGSLSDFVVAGSEDEDHPGSGYETSEDGSLLPVPSAHKARANSLVTLGSQRTSGLLHKQVTVARQASLPGSPQVLRNPLLRQRRVRCYDSNGGSDDEDFDGEGDCISLPGVLPGPGKPLVEDDTRPALTTSSKSIDVNKQEERLQKPLVSKACSVPLLGSSLDSEHSILNGAGGTPPKVASLPGSGETPKNGPRGSGRKEMSGSRSSPKLEYRVPTDTQSPRSPENHTSPPQKSENLVSRHKPVARISPHYKRSDAEEAPGGTANGPCAQDLKVQASPVKDPVTSRQPGGTAEKELRGNPTPGDSSVPTNCGPASTPCHPNIGLPTENPQGAAPECGPHPGTGWDGSSEHLCSPGKSREVHPDSSETPTVAEQVHQPESLSQPVSPRTSEPESQGISKMKPPSQRCVSPREKASTPPDSSRAWAAPGDSSPSTRRIAVPMSTGAAPATAIPQASLVSQERSRGLSGPSKGLGTKELCIPKSLKDGALLEDTAPASGKMSHASSPSGPVATERTLSGSPENPVTDIDNFIEEASEARLSQSPQKADCRAHGDTFESQPPGGAGSSSSHHAQMVRSDQTSSPRKTGGTGSPPPQQWALQPSVLDSIHPDKHLAVNKTFLNNYSRNFSNFHEDSISLSGPGGSSEPSPSSMYGNAEDSSSDPESLAEDPGAAARNNWSPPLSPESSPKEGSSESEDERIEICSTDGCPGTPVTAPPPTQVALCPVLPVQQRAVCKPVGDICERACFVPGASRTSIPDSSQPFSFLDVSSEEPETWASINASQNHMPVCTEGIMDVTSTSSNMGDSQSSQMTRHCRNAPFVLGNPDMVNDLGRDLLDEGAPKEGAAAASVMRSVFALGAEGPKNGEAVLADLHIAERGNLEDLLQKPKTISRRPILTWFKEINKDSQGSHLRSTSEKEQSSMLALGPGSKANMVNTGHRKGVTVPKSPPSRQKSQENKDLPPKSPVETLGNCQKPKCSPKLKRLNSKGKASPEVPVAISTKGSRNDHRKTLPSPQASHKMFSKAVSHRLHIADQEEPKNTAGDTPKPPQCVPESKPPQAALGSLRTSASDTSIRTFTSPLTSPKLLPEQGANSRFHMAVYLESDTSCPTTSRSPRSGPEGKAPHANSGSASPPASRASLALAGIRQSKQFTPGRADLLVSEATQPQGICEKGAEKKVSDPPQRTNQLKIVEISSERVPKNACGDRPPESDRKGGFLTQNNCQEKSAIRLRQSEESSPEHTPFPPSQASQVEREIRWSFSMAKPATSSSSSLQLPAKLPESFQGKSSQMPASVGVPKNGVPIGLAGEESPYFTPRPATRTYSMPAQFSSHFGREGPSPHSPSHSPQDPQVPAMGGKLSEKTAKGVTNGQGVYSVKPLLETSKNLSPVDGRDVSADPETSCLIPDKVKVTRRQYCCEQSWPHESTSFFSVKQRIKSFENLANSDRPTAKCATSPFLSVSSKPPINRRSSGSIPSGSPSDMTSRSLRRSLSSCSESQSEASSLLPQMTKSPSSMTLTVSRQNPPDTSNKGPSPDPKKSLVPVGIPTSTVSPASPSKRNKSSVRHAQPSPVSRSKLQERRTLSMPDLDKLCNGEDDSASPGAVLFKTQLEITPRRSKGSQATSPAGSPARGHADFNGSTFLSCPMNGGTRAYTKGNSPPASEPAIATGSREEGESVWATPSGKSWSVSLDRLLASVGNQQRLQGILSLVGSKSPILTLIQEAKAQSETKEDICFIVLNKKEGSGLGFSVAGGADVEPKSVMVHRVFSQGVASQEGTVSRGDFLLSVNGTSLAGLAHSEVTKVLHQAELHKHALMIIKKGNDQPGPSFKQEPPSANGKGPFPRRTLPLEPGAGRNGAAHDALCVEVLKTSAGLGLSLDGGKSSVSGEGPLVIKRVYKGGAAERAGTIEAGDEILAINGKPLVGLVHFDAWNIMKSVPEGPVQLVIRKHRDS

Computationally mapped potential isoform sequences

There are 5 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6AIY0A0A8I6AIY0_RATPdzd22766
A0A8I6ABF3A0A8I6ABF3_RATPdzd22763
A0A8I6A3J1A0A8I6A3J1_RATPdzd2159
A0A8I5ZMB2A0A8I5ZMB2_RATPdzd22818
F1M785F1M785_RATPdzd2159

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias189-207Polar residues
Compositional bias227-245Polar residues
Compositional bias276-315Basic and acidic residues
Compositional bias423-450Polar residues
Compositional bias627-653Polar residues
Compositional bias783-798Polar residues
Compositional bias1033-1060Polar residues
Compositional bias1126-1140Polar residues
Compositional bias1190-1225Polar residues
Compositional bias1271-1288Polar residues
Compositional bias1320-1346Polar residues
Compositional bias1381-1423Polar residues
Compositional bias1456-1481Polar residues
Compositional bias1846-1860Basic and acidic residues
Compositional bias1880-1908Polar residues
Compositional bias2056-2070Polar residues
Compositional bias2262-2350Polar residues
Compositional bias2360-2394Polar residues
Compositional bias2428-2442Polar residues
Compositional bias2465-2479Polar residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF169411
EMBL· GenBank· DDBJ
AAD55940.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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