Q9QZN9 · CNR2_RAT

  • Protein
    Cannabinoid receptor 2
  • Gene
    Cnr2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Heterotrimeric G protein-coupled receptor for endocannabinoid 2-arachidonoylglycerol mediating inhibition of adenylate cyclase. May function in inflammatory response, nociceptive transmission and bone homeostasis (By similarity).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentdendrite
Cellular Componentendoplasmic reticulum
Cellular Componentextrinsic component of cytoplasmic side of plasma membrane
Cellular Componentneuronal cell body
Cellular Componentperikaryon
Cellular Componentplasma membrane
Cellular Componentpostsynaptic membrane
Molecular Functioncannabinoid receptor activity
Molecular FunctionG protein-coupled receptor activity
Biological Processadenylate cyclase-activating G protein-coupled receptor signaling pathway
Biological ProcessG protein-coupled receptor signaling pathway
Biological Processinflammatory response
Biological Processleukocyte chemotaxis
Biological Processnegative regulation of action potential
Biological Processnegative regulation of mast cell activation
Biological Processnegative regulation of synaptic transmission, GABAergic
Biological Processregulation of metabolic process
Biological Processresponse to amphetamine
Biological Processresponse to lipopolysaccharide
Biological Processtrans-synaptic signaling by endocannabinoid, modulating synaptic transmission

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Cannabinoid receptor 2
  • Short names
    CB-2; CB2; rCB2

Gene names

    • Name
      Cnr2

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9QZN9
  • Secondary accessions
    • Q9EP74

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-33Extracellular
Transmembrane34-59Helical; Name=1
Topological domain60-71Cytoplasmic
Transmembrane72-92Helical; Name=2
Topological domain93-104Extracellular
Transmembrane105-129Helical; Name=3
Topological domain130-149Cytoplasmic
Transmembrane150-172Helical; Name=4
Topological domain173-188Extracellular
Transmembrane189-214Helical; Name=5
Topological domain215-246Cytoplasmic
Transmembrane247-267Helical; Name=6
Topological domain268-279Extracellular
Transmembrane280-301Helical; Name=7
Topological domain302-360Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for chain, glycosylation, modified residue.

TypeIDPosition(s)Description
ChainPRO_00000693251-360Cannabinoid receptor 2
Glycosylation11N-linked (GlcNAc...) asparagine
Modified residue335Phosphoserine
Modified residue336Phosphoserine
Modified residue338Phosphothreonine
Modified residue352Phosphoserine

Post-translational modification

Constitutively phosphorylated on Ser-352; phosphorylation increases cell internalization and desensitizes the receptor.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed in spleen and brain by neurons and glial cells (at protein level). Expressed in lung, testis and thymus but not in heart, liver or kidney. Expressed in cerebellum, cortex and brainstem.

Gene expression databases

Interaction

Protein-protein interaction databases

Chemistry

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region327-360Disordered
Compositional bias339-360Polar residues

Sequence similarities

Belongs to the G-protein coupled receptor 1 family.

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9QZN9-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    360
  • Mass (Da)
    39,359
  • Last updated
    2009-02-10 v3
  • Checksum
    E523C77055B24BE0
MAGCRELELTNGSNGGLEFNPMKEYMILSDAQQIAVAVLCTLMGLLSALENVAVLYLILSSQRLRRKPSYLFIGSLAGADFLASVIFACNFVIFHVFHGVDSRNIFLLKIGSVTMTFTASVGSLLLTAVDRYLCLCYPPTYKALVTRGRALVALGVMWVLSALISYLPLMGWTCCPSPCSELFPLIPNDYLLGWLLFIAILFSGIIYTYGYVLWKAHQHVASLAEHQDRQVPGIARMRLDVRLAKTLGLVMAVLLICWFPALALMGHSLVTTLSDKVKEAFAFCSMLCLVNSMINPIIYALRSGEIRSAAQHCLTGWKKYLQGLGSEGKEEAPKSSVTETEAEVKTTTGPGSRTPGCSNC

Q9QZN9-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 344-360: VKTTTGPGSRTPGCSNC → TLVLKDKQELGGDCLLRTSSIHSPMLSLADSANRQDVRPHCPEELTWWCSVRRPISLPNKAGQSTLL

Features

Showing features for sequence conflict, compositional bias, alternative sequence.

TypeIDPosition(s)Description
Sequence conflict224in Ref. 2; AAG09710/AAG22010/AAG22011
Compositional bias339-360Polar residues
Alternative sequenceVSP_036231344-360in isoform 2

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF176350
EMBL· GenBank· DDBJ
AAF08535.1
EMBL· GenBank· DDBJ
Genomic DNA
AF218846
EMBL· GenBank· DDBJ
AAG09710.1
EMBL· GenBank· DDBJ
mRNA
AF286721
EMBL· GenBank· DDBJ
AAG22010.1
EMBL· GenBank· DDBJ
Genomic DNA
AF286722
EMBL· GenBank· DDBJ
AAG22011.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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