Q9QZD1 · Q9QZD1_RAT

  • Protein
    Stromal cell-derived factor 1
  • Gene
    Cxcl12
  • Status
    UniProtKB unreviewed (TrEMBL)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentexternal side of plasma membrane
Cellular Componentextracellular space
Molecular Functionchemokine activity
Molecular Functionchemokine receptor binding
Molecular FunctionCXCR chemokine receptor binding
Molecular Functionintegrin binding
Biological Processadult locomotory behavior
Biological Processanimal organ regeneration
Biological Processaxon guidance
Biological Processblood vessel endothelial cell migration
Biological Processbrain development
Biological Processbranching involved in blood vessel morphogenesis
Biological Processcell chemotaxis
Biological Processcell migration
Biological Processcell-cell adhesion
Biological Processcellular response to chemokine
Biological Processchemokine (C-X-C motif) ligand 12 signaling pathway
Biological Processchemokine-mediated signaling pathway
Biological ProcessCXCL12-activated CXCR4 signaling pathway
Biological Processdefense response
Biological Processdetection of mechanical stimulus involved in sensory perception of pain
Biological Processdetection of temperature stimulus involved in sensory perception of pain
Biological Processdopaminergic neuron differentiation
Biological Processgerm cell development
Biological Processgerm cell migration
Biological Processimmune response
Biological Processinduction of positive chemotaxis
Biological Processintegrin activation
Biological Processmotor neuron axon guidance
Biological Processnegative regulation of cell population proliferation
Biological Processnegative regulation of dendritic cell apoptotic process
Biological Processnegative regulation of intrinsic apoptotic signaling pathway in response to DNA damage
Biological Processnegative regulation of leukocyte tethering or rolling
Biological Processneuron migration
Biological Processpositive regulation of axon extension involved in axon guidance
Biological Processpositive regulation of calcium ion import
Biological Processpositive regulation of cell adhesion
Biological Processpositive regulation of cell migration
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of chemotaxis
Biological Processpositive regulation of dopamine secretion
Biological Processpositive regulation of endothelial cell proliferation
Biological Processpositive regulation of ERK1 and ERK2 cascade
Biological Processpositive regulation of monocyte chemotaxis
Biological Processpositive regulation of myoblast fusion
Biological Processpositive regulation of neuron differentiation
Biological Processpositive regulation of phosphatidylinositol 3-kinase/protein kinase B signal transduction
Biological Processpositive regulation of T cell migration
Biological Processpositive regulation of vasculature development
Biological Processregulation of calcium ion transport
Biological Processregulation of cell migration
Biological Processresponse to hypoxia
Biological Processresponse to mechanical stimulus
Biological Processresponse to peptide hormone
Biological Processresponse to ultrasound
Biological ProcessT cell proliferation
Biological Processtelencephalon cell migration

Keywords

  • Molecular function

Names & Taxonomy

Protein names

  • Recommended name
    Stromal cell-derived factor 1
  • Alternative names
    • C-X-C motif chemokine 12

Gene names

    • Name
      Cxcl12
    • Synonyms
      SDF-1

Organism names

  • Taxonomic identifier
  • Organism
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9QZD1

Organism-specific databases

Subcellular Location

PTM/Processing

Features

Showing features for signal, chain.

TypeIDPosition(s)Description
Signal1-21
ChainPRO_501431316322-89Stromal cell-derived factor 1

Keywords

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain27-86Chemokine interleukin-8-like

Sequence similarities

Belongs to the intercrine alpha (chemokine CxC) family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    89
  • Mass (Da)
    9,977
  • Last updated
    2000-05-01 v1
  • Checksum
    D86977626A2E35FA
MDAKVVAVLALVLAALCISDGKPVSLSYRCPCRFFESHVARANVKHLKILNTPNCALQIVARLKSNNRQVCIDPKLKWIQEYLDKALNK

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF189724
EMBL· GenBank· DDBJ
AAF01066.1
EMBL· GenBank· DDBJ
mRNA
AF209976
EMBL· GenBank· DDBJ
AAG43506.1
EMBL· GenBank· DDBJ
mRNA
BC078737
EMBL· GenBank· DDBJ
AAH78737.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp