Q9QYV0 · ADA15_RAT
- ProteinDisintegrin and metalloproteinase domain-containing protein 15
- GeneAdam15
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids864 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score5/5
Function
function
Cofactor
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 180 | Zn2+ (UniProtKB | ChEBI); catalytic; in inhibited form | |||
Binding site | 350 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Active site | 351 | ||||
Binding site | 354 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
Binding site | 360 | Zn2+ (UniProtKB | ChEBI); catalytic | |||
GO annotations
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Protein family/group databases
Names & Taxonomy
Protein names
- Recommended nameDisintegrin and metalloproteinase domain-containing protein 15
- EC number
- Short namesADAM 15
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus
Accessions
- Primary accessionQ9QYV0
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Topological domain | 209-698 | Extracellular | |||
Transmembrane | 699-719 | Helical | |||
Topological domain | 720-864 | Cytoplasmic | |||
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for signal, propeptide, glycosylation, chain, disulfide bond, modified residue.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Signal | 1-17 | ||||
Propeptide | PRO_0000029086 | 18-208 | |||
Glycosylation | 57 | N-linked (GlcNAc...) asparagine | |||
Chain | PRO_0000029087 | 209-864 | Disintegrin and metalloproteinase domain-containing protein 15 | ||
Glycosylation | 239 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 325↔411 | ||||
Disulfide bond | 367↔395 | ||||
Disulfide bond | 369↔378 | ||||
Glycosylation | 391 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 394 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 482↔502 | ||||
Glycosylation | 608 | N-linked (GlcNAc...) asparagine | |||
Glycosylation | 613 | N-linked (GlcNAc...) asparagine | |||
Disulfide bond | 659↔669 | ||||
Disulfide bond | 663↔675 | ||||
Disulfide bond | 677↔686 | ||||
Modified residue | 717 | Phosphotyrosine; by HCK and LCK | |||
Modified residue | 737 | Phosphotyrosine; by HCK and LCK | |||
Post-translational modification
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Induction
Gene expression databases
Interaction
Subunit
Interacts with ITAG9-ITGB1. Interacts specifically with Src family protein-tyrosine kinases (PTKs). Interacts with SH3PXD2A. Interacts with ITAGV-ITGB1. Interacts with GRB2, HCK, ITSN1, ITSN2, LYN, MAPK1, MAPK3, NCF1, NCK1, nephrocystin, PTK6, SNX33, LCK and SRC (By similarity).
Protein-protein interaction databases
Structure
Family & Domains
Features
Showing features for region, compositional bias, motif, domain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Region | 17-49 | Disordered | |||
Compositional bias | 27-49 | Polar residues | |||
Motif | 178-185 | Cysteine switch | |||
Domain | 215-416 | Peptidase M12B | |||
Domain | 423-510 | Disintegrin | |||
Domain | 659-687 | EGF-like | |||
Region | 738-864 | Disordered | |||
Compositional bias | 796-834 | Pro residues | |||
Motif | 816-822 | SH3-binding | |||
Compositional bias | 849-864 | Pro residues | |||
Motif | 851-857 | SH3-binding | |||
Domain
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
This entry describes 2 isoforms produced by Alternative splicing.
Q9QYV0-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length864
- Mass (Da)93,308
- Last updated2010-07-13 v2
- Checksum5D46466922A89196
Q9QYV0-2
- Name2
- Differences from canonical
- 762-809: Missing
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
A0A8I6AF83 | A0A8I6AF83_RAT | Adam15 | 840 |
Features
Showing features for compositional bias, sequence conflict, alternative sequence.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Compositional bias | 27-49 | Polar residues | |||
Sequence conflict | 202 | in Ref. 2; AAH61796 | |||
Alternative sequence | VSP_039534 | 762-809 | in isoform 2 | ||
Compositional bias | 796-834 | Pro residues | |||
Compositional bias | 849-864 | Pro residues | |||
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AJ251198 EMBL· GenBank· DDBJ | CAB61762.1 EMBL· GenBank· DDBJ | mRNA | ||
BC061796 EMBL· GenBank· DDBJ | AAH61796.1 EMBL· GenBank· DDBJ | mRNA |