Q9QYS2 · GRM3_MOUSE
- ProteinMetabotropic glutamate receptor 3
- GeneGrm3
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids879 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Binding site | 151 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: S | ||||||
Binding site | 172-174 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: AST | ||||||
Binding site | 222 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: Y | ||||||
Binding site | 301 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: D | ||||||
Binding site | 389 | L-glutamate (UniProtKB | ChEBI) | ||||
Sequence: K |
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | astrocyte projection | |
Cellular Component | axon | |
Cellular Component | dendritic spine | |
Cellular Component | glutamatergic synapse | |
Cellular Component | neuron projection | |
Cellular Component | plasma membrane | |
Cellular Component | postsynaptic density | |
Cellular Component | postsynaptic membrane | |
Cellular Component | presynaptic active zone | |
Cellular Component | presynaptic membrane | |
Molecular Function | calcium channel regulator activity | |
Molecular Function | group II metabotropic glutamate receptor activity | |
Molecular Function | scaffold protein binding | |
Biological Process | G protein-coupled glutamate receptor signaling pathway | |
Biological Process | gene expression | |
Biological Process | modulation of chemical synaptic transmission | |
Biological Process | postsynaptic modulation of chemical synaptic transmission | |
Biological Process | regulation of sensory perception of pain | |
Biological Process | regulation of synaptic transmission, glutamatergic | |
Biological Process | sensory perception of pain | |
Biological Process | synaptic transmission, glutamatergic |
Keywords
- Molecular function
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMetabotropic glutamate receptor 3
- Short namesmGluR3
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9QYS2
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
UniProt Annotation
GO Annotation
Cell membrane ; Multi-pass membrane protein
Features
Showing features for topological domain, transmembrane.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Topological domain | 23-576 | Extracellular | ||||
Sequence: LGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIRWEDAW | ||||||
Transmembrane | 577-599 | Helical; Name=1 | ||||
Sequence: AIGPVTIACLGFMCTCIVITVFI | ||||||
Topological domain | 600-613 | Cytoplasmic | ||||
Sequence: KHNNTPLVKASGRE | ||||||
Transmembrane | 614-634 | Helical; Name=2 | ||||
Sequence: LCYILLFGVSLSYCMTFFFIA | ||||||
Topological domain | 635-645 | Extracellular | ||||
Sequence: KPSPVICALRR | ||||||
Transmembrane | 646-664 | Helical; Name=3 | ||||
Sequence: LGLGTSFAICYSALLTKTN | ||||||
Topological domain | 665-688 | Cytoplasmic | ||||
Sequence: CIARIFDGVKNGAQRPKFISPSSQ | ||||||
Transmembrane | 689-709 | Helical; Name=4 | ||||
Sequence: VFICLGLILVQIVMVSVWLIL | ||||||
Topological domain | 710-734 | Extracellular | ||||
Sequence: ETPGTRRYTLPEKRETVILKCNVKD | ||||||
Transmembrane | 735-756 | Helical; Name=5 | ||||
Sequence: SSMLISLTYDVVLVILCTVYAF | ||||||
Topological domain | 757-769 | Cytoplasmic | ||||
Sequence: KTRKCPENFNEAK | ||||||
Transmembrane | 770-792 | Helical; Name=6 | ||||
Sequence: FIGFTMYTTCIIWLAFLPIFYVT | ||||||
Topological domain | 793-802 | Extracellular | ||||
Sequence: SSDYRVQTTT | ||||||
Transmembrane | 803-828 | Helical; Name=7 | ||||
Sequence: MCISVSLSGFVVLGCLFAPKVHIVLF | ||||||
Topological domain | 829-879 | Cytoplasmic | ||||
Sequence: QPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL |
Keywords
- Cellular component
Phenotypes & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.
Chemistry
PTM/Processing
Features
Showing features for signal, chain, disulfide bond, glycosylation.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Signal | 1-22 | |||||
Sequence: MKMLTRLQVLMLALFSKGFLVS | ||||||
Chain | PRO_0000012928 | 23-879 | Metabotropic glutamate receptor 3 | |||
Sequence: LGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIRWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL | ||||||
Disulfide bond | 57↔99 | |||||
Sequence: CGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTC | ||||||
Glycosylation | 209 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 240↔527 | |||||
Sequence: CIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVC | ||||||
Glycosylation | 292 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 361↔373 | |||||
Sequence: CSLQNKRNHRQIC | ||||||
Disulfide bond | 412↔419 | |||||
Sequence: CPNTTKLC | ||||||
Glycosylation | 414 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Glycosylation | 439 | N-linked (GlcNAc...) asparagine | ||||
Sequence: N | ||||||
Disulfide bond | 509↔528 | |||||
Sequence: CSDPCAPNEMKNMQPGDVCC | ||||||
Disulfide bond | 513↔531 | |||||
Sequence: CAPNEMKNMQPGDVCCWIC | ||||||
Disulfide bond | 534↔546 | |||||
Sequence: CEPYEYLVDEFTC | ||||||
Disulfide bond | 549↔562 | |||||
Sequence: CGPGQWPTADLSGC |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Gene expression databases
Structure
Sequence
- Sequence statusComplete
- Sequence processingThe displayed sequence is further processed into a mature form.
- Length879
- Mass (Da)99,114
- Last updated2000-05-01 v1
- ChecksumF3A8B26CE96679EF
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF170701 EMBL· GenBank· DDBJ | AAF06741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF170697 EMBL· GenBank· DDBJ | AAF06741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF170698 EMBL· GenBank· DDBJ | AAF06741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF170699 EMBL· GenBank· DDBJ | AAF06741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AF170700 EMBL· GenBank· DDBJ | AAF06741.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC111891 EMBL· GenBank· DDBJ | AAI11892.1 EMBL· GenBank· DDBJ | mRNA | ||
BC113170 EMBL· GenBank· DDBJ | AAI13171.1 EMBL· GenBank· DDBJ | mRNA |