Q9QYS2 · GRM3_MOUSE

  • Protein
    Metabotropic glutamate receptor 3
  • Gene
    Grm3
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity.

Features

Showing features for binding site.

1879100200300400500600700800
TypeIDPosition(s)Description
Binding site151L-glutamate (UniProtKB | ChEBI)
Binding site172-174L-glutamate (UniProtKB | ChEBI)
Binding site222L-glutamate (UniProtKB | ChEBI)
Binding site301L-glutamate (UniProtKB | ChEBI)
Binding site389L-glutamate (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentastrocyte projection
Cellular Componentaxon
Cellular Componentdendritic spine
Cellular Componentglutamatergic synapse
Cellular Componentneuron projection
Cellular Componentplasma membrane
Cellular Componentpostsynaptic density
Cellular Componentpostsynaptic membrane
Cellular Componentpresynaptic active zone
Cellular Componentpresynaptic membrane
Molecular Functioncalcium channel regulator activity
Molecular Functiongroup II metabotropic glutamate receptor activity
Molecular Functionscaffold protein binding
Biological ProcessG protein-coupled glutamate receptor signaling pathway
Biological Processgene expression
Biological Processmodulation of chemical synaptic transmission
Biological Processpostsynaptic modulation of chemical synaptic transmission
Biological Processregulation of sensory perception of pain
Biological Processregulation of synaptic transmission, glutamatergic
Biological Processsensory perception of pain
Biological Processsynaptic transmission, glutamatergic

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Metabotropic glutamate receptor 3
  • Short names
    mGluR3

Gene names

    • Name
      Grm3
    • Synonyms
      Gprc1c, Mglur3

Organism names

  • Taxonomic identifier
  • Strain
    • 129/Sv
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9QYS2
  • Secondary accessions
    • Q14DJ9

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain23-576Extracellular
Transmembrane577-599Helical; Name=1
Topological domain600-613Cytoplasmic
Transmembrane614-634Helical; Name=2
Topological domain635-645Extracellular
Transmembrane646-664Helical; Name=3
Topological domain665-688Cytoplasmic
Transmembrane689-709Helical; Name=4
Topological domain710-734Extracellular
Transmembrane735-756Helical; Name=5
Topological domain757-769Cytoplasmic
Transmembrane770-792Helical; Name=6
Topological domain793-802Extracellular
Transmembrane803-828Helical; Name=7
Topological domain829-879Cytoplasmic

Keywords

Phenotypes & Variants

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 22 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Chemistry

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_000001292823-879Metabotropic glutamate receptor 3
Disulfide bond57↔99
Glycosylation209N-linked (GlcNAc...) asparagine
Disulfide bond240↔527
Glycosylation292N-linked (GlcNAc...) asparagine
Disulfide bond361↔373
Disulfide bond412↔419
Glycosylation414N-linked (GlcNAc...) asparagine
Glycosylation439N-linked (GlcNAc...) asparagine
Disulfide bond509↔528
Disulfide bond513↔531
Disulfide bond534↔546
Disulfide bond549↔562

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Interacts with TAMALIN.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Protein family/group databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    879
  • Mass (Da)
    99,114
  • Last updated
    2000-05-01 v1
  • Checksum
    F3A8B26CE96679EF
MKMLTRLQVLMLALFSKGFLVSLGDHNFMRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFAIDEINKDNYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRYFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRVNASFTWVASDGWGAQESIVKGSEHVAYGAITLELASHPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRQICDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKGADSIVKFDTYGDGMGRYNVFNFQHIGGKYSYLKVGHWAETLYLDVDSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLVDEFTCMDCGPGQWPTADLSGCYNLPEDYIRWEDAWAIGPVTIACLGFMCTCIVITVFIKHNNTPLVKASGRELCYILLFGVSLSYCMTFFFIAKPSPVICALRRLGLGTSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILETPGTRRYTLPEKRETVILKCNVKDSSMLISLTYDVVLVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVQTTTMCISVSLSGFVVLGCLFAPKVHIVLFQPQKNVVTHRLHLNRFSVSGTATTYSQSSASTYVPTVCNGREVLDSTTSSL

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF170701
EMBL· GenBank· DDBJ
AAF06741.1
EMBL· GenBank· DDBJ
Genomic DNA
AF170697
EMBL· GenBank· DDBJ
AAF06741.1
EMBL· GenBank· DDBJ
Genomic DNA
AF170698
EMBL· GenBank· DDBJ
AAF06741.1
EMBL· GenBank· DDBJ
Genomic DNA
AF170699
EMBL· GenBank· DDBJ
AAF06741.1
EMBL· GenBank· DDBJ
Genomic DNA
AF170700
EMBL· GenBank· DDBJ
AAF06741.1
EMBL· GenBank· DDBJ
Genomic DNA
BC111891
EMBL· GenBank· DDBJ
AAI11892.1
EMBL· GenBank· DDBJ
mRNA
BC113170
EMBL· GenBank· DDBJ
AAI13171.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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