Q9QYP6 · AZI2_MOUSE
- Protein5-azacytidine-induced protein 2
- GeneAzi2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids405 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Adapter protein which binds TBK1 and IKBKE playing a role in antiviral innate immunity. Activates serine/threonine-protein kinase TBK1 and facilitates its oligomerization. Enhances the phosphorylation of NF-kappa-B p65 subunit RELA by TBK1. Promotes TBK1-induced as well as TNF-alpha or PMA-induced activation of NF-kappa-B. Participates in IFNB promoter activation via TICAM1.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Biological Process | dendritic cell differentiation | |
Biological Process | dendritic cell proliferation | |
Biological Process | mitotic cell cycle | |
Biological Process | negative regulation of canonical NF-kappaB signal transduction | |
Biological Process | T cell activation |
Names & Taxonomy
Protein names
- Recommended name5-azacytidine-induced protein 2
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9QYP6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Phenotypes & Variants
Features
Showing features for mutagenesis.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Mutagenesis | 236 | Abolishes interaction with TBK1 but not with IKBKE. | ||||
Sequence: Y → A | ||||||
Mutagenesis | 237 | No effect on interaction with TBK1 and IKBKE. | ||||
Sequence: W → A | ||||||
Mutagenesis | 238 | No effect on interaction with TBK1 and IKBKE. | ||||
Sequence: E → A | ||||||
Mutagenesis | 253 | Abolishes interaction with TBK1 and IKBKE. | ||||
Sequence: Q → A | ||||||
Mutagenesis | 257 | Abolishes interaction with TBK1 and IKBKE. | ||||
Sequence: L → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 23 variants from UniProt as well as other sources including ClinVar and dbSNP.
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000280604 | 1-405 | 5-azacytidine-induced protein 2 | |||
Sequence: MDTLVEDDICILNHEKAHRREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQTGPPQEDILQGRDVIRPSLSREEHVPHQGLHHSDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKACTPVGCVEDLGRDSTKLHLTNFTATYKRHPSLSPNGKAPCYAPSSPLPGDRKVFSDKAVLQSWTDNERLVPNDGADFPEHSSYGRNSLEDNSWVFPSPPKSSETAFGENKSKILPLSNLPPLHYLDQQNQNCLYKS | ||||||
Modified residue | 331 | Phosphoserine | ||||
Sequence: S | ||||||
Modified residue | 366 | Phosphoserine | ||||
Sequence: S |
Post-translational modification
Ubiquitinated via 'Lys-48'-linked polyubiquitination by TRIM38, leading to its degradation.
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Testis, ovary, heart, lung, kidney and brain. Expressed mainly in the spermatocytes or spermatids in the testis.
Induction
By 5-azacytidine.
Gene expression databases
Interaction
Subunit
Homodimer (PubMed:17568778).
Interacts with IKBKE and TBK1 (PubMed:17568778).
Interacts with TICAM1 (By similarity).
Interacts with TAX1BP1 (By similarity).
Interacts with CALCOCO2 (By similarity).
Interacts with IKBKE and TBK1 (PubMed:17568778).
Interacts with TICAM1 (By similarity).
Interacts with TAX1BP1 (By similarity).
Interacts with CALCOCO2 (By similarity).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q9QYP6 | APBA3 O96018 | 2 | EBI-6115874, EBI-6115839 | |
XENO | Q9QYP6 | MIB1 Q86YT6 | 2 | EBI-6115874, EBI-2129148 | |
XENO | Q9QYP6 | MTPAP Q9NVV4 | 2 | EBI-6115874, EBI-2556166 | |
XENO | Q9QYP6 | N4BP1 O75113 | 2 | EBI-6115874, EBI-5278391 | |
XENO | Q9QYP6 | RNF31 Q96EP0 | 2 | EBI-6115874, EBI-948111 | |
XENO | Q9QYP6 | TRAF3 Q13114 | 2 | EBI-6115874, EBI-357631 | |
XENO | Q9QYP6 | TXLNA P40222 | 2 | EBI-6115874, EBI-359793 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-198 | Homodimerization | ||||
Sequence: MDTLVEDDICILNHEKAHRREAVTPLSAYPGDESVASHFALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQTG | ||||||
Coiled coil | 40-197 | |||||
Sequence: ALVTAYEDIKKRLKDSEKENSFLKKRIRALEERLVGARADEETSSVGREQVNKAYHAYREVCIDRDNLKNQLEKINKDNSESLKMLNEQLQSKEVELLQLRTEVETQQVMRNLNPPSSSWEVEKLSCDLKIHGLEQELGLLRKECSDLRTELQKARQT | ||||||
Region | 229-270 | Interaction with TBK1 and IKBKE | ||||
Sequence: SDNMQHAYWELKREMSNLHLVTQVQAELLRKLKTSAAVKKAC | ||||||
Region | 357-377 | Disordered | ||||
Sequence: LEDNSWVFPSPPKSSETAFGE |
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 3 isoforms produced by Alternative splicing.
Q9QYP6-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length405
- Mass (Da)46,091
- Last updated2000-05-01 v1
- Checksum5EBD91369CBCB89F
Q9QYP6-2
- Name2
Q9QYP6-3
- Name3
- NoteMay be produced at very low levels due to a premature stop codon in the mRNA, leading to nonsense-mediated mRNA decay.
- Differences from canonical
- 115-405: Missing
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Features
Showing features for alternative sequence.
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB007141 EMBL· GenBank· DDBJ | BAA88213.1 EMBL· GenBank· DDBJ | mRNA | ||
AK004992 EMBL· GenBank· DDBJ | BAB23727.1 EMBL· GenBank· DDBJ | mRNA | ||
AK015942 EMBL· GenBank· DDBJ | BAB30044.1 EMBL· GenBank· DDBJ | mRNA | ||
AK030076 EMBL· GenBank· DDBJ | BAC26770.1 EMBL· GenBank· DDBJ | mRNA | ||
AK036102 EMBL· GenBank· DDBJ | BAE43294.1 EMBL· GenBank· DDBJ | mRNA | ||
AK153477 EMBL· GenBank· DDBJ | BAE32027.1 EMBL· GenBank· DDBJ | mRNA | ||
AK165549 EMBL· GenBank· DDBJ | BAE38249.1 EMBL· GenBank· DDBJ | mRNA | ||
AK167783 EMBL· GenBank· DDBJ | BAE39815.1 EMBL· GenBank· DDBJ | mRNA | ||
BC006851 EMBL· GenBank· DDBJ | AAH06851.1 EMBL· GenBank· DDBJ | mRNA |