Q9QYN5 · BCL10_RAT

  • Protein
    B-cell lymphoma/leukemia 10
  • Gene
    Bcl10
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at transcript level
  • Annotation score
    5/5

Function

function

Plays a key role in both adaptive and innate immune signaling by bridging CARD domain-containing proteins to immune activation. Acts by channeling adaptive and innate immune signaling downstream of CARD domain-containing proteins CARD9, CARD11 and CARD14 to activate NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Recruited by activated CARD domain-containing proteins: homooligomerized CARD domain-containing proteins form a nucleating helical template that recruits BCL10 via CARD-CARD interaction, thereby promoting polymerization of BCL10, subsequent recruitment of MALT1 and formation of a CBM complex. This leads to activation of NF-kappa-B and MAP kinase p38 (MAPK11, MAPK12, MAPK13 and/or MAPK14) pathways which stimulate expression of genes encoding pro-inflammatory cytokines and chemokines. Activated by CARD9 downstream of C-type lectin receptors; CARD9-mediated signals are essential for antifungal immunity. Activated by CARD11 downstream of T-cell receptor (TCR) and B-cell receptor (BCR). Promotes apoptosis, pro-caspase-9 maturation and activation of NF-kappa-B via NIK and IKK.

Features

Showing features for site.

123320406080100120140160180200220
TypeIDPosition(s)Description
Site228-229Cleavage; by MALT1

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentCBM complex
Cellular Componentcytoplasm
Cellular Componentcytoplasmic microtubule
Cellular Componentcytosol
Cellular Componentimmunological synapse
Cellular Componentlysosome
Cellular Componentmembrane raft
Cellular Componentnucleus
Cellular Componentperinuclear region of cytoplasm
Cellular Componentpolkadots
Cellular Componentprotein-containing complex
Molecular FunctionCARD domain binding
Molecular Functiongeneral transcription initiation factor binding
Molecular Functionidentical protein binding
Molecular Functionkinase activator activity
Molecular FunctionNF-kappaB binding
Molecular Functionprotease binding
Molecular Functionprotein kinase B binding
Molecular Functionprotein-containing complex binding
Molecular Functionprotein-macromolecule adaptor activity
Molecular Functionsignaling adaptor activity
Molecular Functiontranscription coactivator activity
Molecular Functionubiquitin protein ligase binding
Biological Processadaptive immune response
Biological Processantifungal innate immune response
Biological ProcessB cell apoptotic process
Biological Processcellular defense response
Biological Processcellular response to lipopolysaccharide
Biological Processcellular response to mechanical stimulus
Biological Processimmunoglobulin mediated immune response
Biological Processinnate immune response
Biological Processlipopolysaccharide-mediated signaling pathway
Biological Processnegative regulation of mature B cell apoptotic process
Biological Processneural tube closure
Biological Processnon-canonical NF-kappaB signal transduction
Biological Processpositive regulation of apoptotic process
Biological Processpositive regulation of canonical NF-kappaB signal transduction
Biological Processpositive regulation of cytokine production
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of extrinsic apoptotic signaling pathway
Biological Processpositive regulation of interleukin-8 production
Biological Processpositive regulation of NF-kappaB transcription factor activity
Biological Processpositive regulation of phosphorylation
Biological Processpositive regulation of protein ubiquitination
Biological Processpositive regulation of T cell activation
Biological Processpositive regulation of T cell receptor signaling pathway
Biological Processprogrammed cell death
Biological Processprotein homooligomerization
Biological Processregulation of T cell receptor signaling pathway
Biological Processresponse to food
Biological Processresponse to fungus
Biological Processresponse to lipopolysaccharide
Biological ProcessT cell apoptotic process
Biological ProcessT cell receptor signaling pathway
Biological Processtoll-like receptor signaling pathway

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    B-cell lymphoma/leukemia 10
  • Alternative names
    • B-cell CLL/lymphoma 10
      (Bcl-10
      )
    • R-RCD1 (RCD)

Gene names

    • Name
      Bcl10

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9QYN5

Proteomes

Organism-specific databases

Subcellular Location

Membrane raft
Note: Appears to have a perinuclear, compact and filamentous pattern of expression. Also found in the nucleus of several types of tumor cells. Colocalized with DPP4 in membrane rafts.

Keywords

Phenotypes & Variants

Variants

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The viewer provides 1 variant from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Keywords

PTM/Processing

Features

Showing features for modified residue, chain, cross-link.

TypeIDPosition(s)Description
Modified residue1N-acetylmethionine
ChainPRO_00001440761-233B-cell lymphoma/leukemia 10
Cross-link17Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-link31Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Cross-link63Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in ubiquitin)
Modified residue138Phosphoserine

Post-translational modification

Phosphorylated. Phosphorylation results in dissociation from TRAF2 and binding to BIRC2/c-IAP2. Phosphorylated by IKBKB/IKKB.
Ubiquitinated via both 'Lys-63'-linked and linear ('Met-1'-linked) polyubiquitin chains in response to T-cell receptor (TCR) activation. Ubiquitination is recognized by IKBKG/NEMO, the regulatory subunit of I-kappa-B kinase (IKK), and is required for TCR-induced NF-kappa-B activation. Linear ubiquitination at Lys-17, Lys-31 and Lys-63 is mediated by RNF31/HOIP; linear ubiquitination is recognized with much higher affinity than 'Lys-63'-linked ubiquitin by IKBKG/NEMO. CARD11 is required for linear ubiquitination by HOIP by promoting the targeting of BCL10 to RNF31/HOIP.
Proteolytically cleaved by MALT1; required for T-cell activation.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Subunit

Homomultimer; homooligomerized following recruitment by CARD domain-containing proteins that form a nucleating helical template that recruits BCL10 via CARD-CARD interaction. Self-associates by CARD-CARD interaction and interacts with other CARD-proteins such as CARD9, CARD10, CARD11 and CARD14. Forms a complex with CARD14 and MALT1; resulting in the formation of a CBM (CARD14-BCL10-MALT1) complex. Forms a complex with CARD11 and MALT1; resulting in the formation of a CBM (CARD11-BCL10-MALT1) complex (By similarity).
Forms a complex with CARD9 and MALT1; resulting in the formation of a CBM (CARD9-BCL10-MALT1) complex (By similarity).
Found in a membrane raft complex, at least composed of BCL10, CARD11, DPP4 and IKBKB. Binds caspase-9 with its C-terminal domain. Interacts with TRAF2 and BIRC2/c-IAP2 (By similarity).
Interacts with PELI2 and SOCS3; these interactions may be mutually exclusive (By similarity).

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain13-101CARD
Region130-149Disordered
Region186-233Disordered

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    233
  • Mass (Da)
    25,999
  • Last updated
    2000-05-01 v1
  • Checksum
    B43274B4B825FC7D
MEAPAPSLTEEDLTEVKKDALENLRVYLCEKIIAERHFDHLRAKKILSREDTEEISCRTSSRKRAGKLLDYLQENPKGLDTLVESIRREKTQNFLIQKITDEVLKLRNIKLEHLKGLKCSSCEPFAAGATNNLSRSNSDESNFSEKQRPSTVIYHPEGESSTAPFFSTESSLNLPVLEVGRLENSSFSSASLPRPGDPGAPPLPPDLRLEEGGSCGNSSEMFLPLRSRALSRQ

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I6A3W9A0A8I6A3W9_RATBcl10214

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB016069
EMBL· GenBank· DDBJ
BAA88822.1
EMBL· GenBank· DDBJ
mRNA
BC061772
EMBL· GenBank· DDBJ
AAH61772.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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