Q9QY84 · ACL7A_MOUSE

  • Protein
    Actin-like protein 7A
  • Gene
    Actl7a
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

May play an important role in formation and fusion of Golgi-derived vesicles during acrosome biogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentacrosomal vesicle
Cellular Componentcytoplasm
Cellular Componentcytoskeleton
Cellular ComponentGolgi apparatus
Cellular Componentmale germ cell nucleus
Cellular Componentmotile cilium
Cellular Componentnucleus
Cellular Componentprotein-containing complex
Biological Processacrosome assembly
Biological Processfertilization
Biological Processsingle fertilization

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Actin-like protein 7A
  • Alternative names
    • Actin-like-7-alpha
    • Testis-specific actin-2 (T-actin-2)

Gene names

    • Name
      Actl7a
    • Synonyms
      Tact2

Organism names

  • Taxonomic identifier
  • Strains
    • CD-1
    • 129/Sv
    • C57BL/6J
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus

Accessions

  • Primary accession
    Q9QY84
  • Secondary accessions
    • A2AMK4
    • Q9D9P4
    • Q9JMI5

Proteomes

Organism-specific databases

Subcellular Location

Golgi apparatus
Cytoplasm
Nucleus
Note: Detected at the Golgi apparatus during acrosome biogenesis (PubMed:21278383).
Detected at the subacrosomal layer in round spermatids (PubMed:21278383).
Detected in sperm head and tail (PubMed:21278383).

Keywords

Phenotypes & Variants

Features

Showing features for mutagenesis.

TypeIDPosition(s)Description
Mutagenesis250Homozygous knockin male mice are infertile. The spermatogenesis process is normal. However spermatozoa dysplay acrosomal ultrastructural defects. Complete absence of the ACTL7A protein in both testes and sperms. Abnormal distribution of PLCZ1 in sperms.

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 27 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000891381-440Actin-like protein 7A

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in testis. Detected at the acrosome of round spermatids (at protein level). Detected in adult and embryonic testis. Detected in developing male germ cells.

Gene expression databases

Interaction

Subunit

Interacts (via N-terminus) with TES (via LIM domain 2). Heterodimer with TES; the heterodimer interacts with ENAH to form a heterotrimer. Interacts with ACTL9.

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region1-29Disordered
Region36-56Required for interaction with TES

Sequence similarities

Belongs to the actin family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    440
  • Mass (Da)
    49,451
  • Last updated
    2000-05-01 v1
  • Checksum
    1909838FB9D8DEC6
MSLDGVWAPQTANIGDGPAKKASDQASMQTQVLQTASLKDGPAKRAVWVRRDNAETEDPVKSTMSKDRPRLEVTKAVVVDLGTGFCKCGFAGLPKPTHKISTTVGKPYMETAKTGDNRKETFVGHELFNPDIHLKLVNPLRHGIIVDWDTVQDIWEYLFRQEMKIAPEEHAVLVSDPPLSPHTNREKYAEMLFETFNTPAMHIAYQSRLSMYSYGRTSGLVVEVGHGVSYVVPIYEGYPLPSITGRLDYAGSDLTTYLMNLMNNSGKHFSEDHLGIVEDIKTRCCFVALDPIEEKKIPAPEHEIHYTLPDGKEIRLGQERFLCSEMFFKPSLIKSMQLGLHTQTVSCLNKCDIALKRDLMGNILLCGGSTMLRGFPNRLQKELSSMCPNDTPQVNVLPERDTAVWTGGSILASLQGFQPLWVHRLEYEEHGPFFLYRRCF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict176-181in Ref. 4; BAB24681
Sequence conflict224in Ref. 4; BAB24681
Sequence conflict290in Ref. 4; BAB24681
Sequence conflict328in Ref. 2; BAA90822
Sequence conflict373in Ref. 4; BAB24681

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF113519
EMBL· GenBank· DDBJ
AAF18298.1
EMBL· GenBank· DDBJ
mRNA
AB023063
EMBL· GenBank· DDBJ
BAA90822.1
EMBL· GenBank· DDBJ
mRNA
AB079643
EMBL· GenBank· DDBJ
BAC07297.1
EMBL· GenBank· DDBJ
Genomic DNA
AL807762
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH466565
EMBL· GenBank· DDBJ
EDL02258.1
EMBL· GenBank· DDBJ
Genomic DNA
AK006631
EMBL· GenBank· DDBJ
BAB24681.1
EMBL· GenBank· DDBJ
mRNA
BC049610
EMBL· GenBank· DDBJ
AAH49610.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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