Q9QXT9 · Z354B_MOUSE
- ProteinZinc finger protein 354B
- GeneZnf354b
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids601 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score4/5
Function
function
Transcriptional repressor that binds DNA upon activation by RAS proteins signal transduction to initiate transcriptional silencing through the recruitment of additional DNA-binding proteins, multisubunit complexes and chromatin-modifying activities to establish a platform for DNMT1 recruitment.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | nucleus | |
Molecular Function | chromatin binding | |
Molecular Function | DNA-binding transcription factor activity, RNA polymerase II-specific | |
Molecular Function | metal ion binding | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | transcription corepressor activity | |
Biological Process | negative regulation of transcription by RNA polymerase II | |
Biological Process | regulation of transcription by RNA polymerase II |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameZinc finger protein 354B
- Alternative names
Gene names
Organism names
- Organism
- Strains
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Mus > Mus
Accessions
- Primary accessionQ9QXT9
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
PTM/Processing
Features
Showing features for chain, cross-link.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000280407 | 1-601 | Zinc finger protein 354B | |||
Sequence: MAPEQREGKSQVSVTFEDVAVLFTRDEWKKLVPSQRSLYREVMLENYSNLASLGFPFTKPKMISVLQQGEEPWKSEKESHGCSPLGCHGSLQTTKSTQTKESLFQELKRKQLKRDEAWDFTSGKSCRPDNSFRTQDTNESLEIISINHTKILTIDKSRKNFKFGPSVGLKSIGKQKIAGEKTQRNSLEENSTLLSQPKLKTVEKRYKCSTCEKAFIHNSSLRKHLKNHTGERLFQCKDCLKAFSQSSALIQHQRTHTGEKPYICKECGKAFSHSASLCKHLRTHTLEKSYTCKECGKSFSRRSGLFLHQKIHARENPHKYNPGRKASTSLSGCQRIHSRKKTYLCNECGNTFKSSSSLRYHQRIHTGEKPFKCSECGRAFSQSASLIQHERIHTGEKPYRCSECGKGFTSISRLNRHRIIHTGEKFYNCNECGKALSSHSTLIIHERIHTGEKPCKCKVCGKAFRQSSALIQHQRMHTGERPYKCNECGKTFRCNSSLSNHQRTHTGEKPYRCQECGMSFGQSAALIQHRRIHTGEKPFKCNTCGKSFRQSSSLIAHQRIHTGEKPYECSACGKLFSQRSSLTNHYRIHIEEDALNIDLHE | ||||||
Cross-link | 150 | Glycyl lysine isopeptide (Lys-Gly) (interchain with G-Cter in SUMO2) | ||||
Sequence: K |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed in brain and kidney. Lower levels in lung, muscle, heart, testis, tongue and eye.
Developmental stage
Expressed at 16.5 dpc in brain, heart, lung, kidney and gut.
Gene expression databases
Structure
Family & Domains
Features
Showing features for domain, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 14-85 | KRAB | ||||
Sequence: VTFEDVAVLFTRDEWKKLVPSQRSLYREVMLENYSNLASLGFPFTKPKMISVLQQGEEPWKSEKESHGCSPL | ||||||
Zinc finger | 206-228 | C2H2-type 1 | ||||
Sequence: YKCSTCEKAFIHNSSLRKHLKNH | ||||||
Zinc finger | 234-256 | C2H2-type 2 | ||||
Sequence: FQCKDCLKAFSQSSALIQHQRTH | ||||||
Zinc finger | 262-284 | C2H2-type 3 | ||||
Sequence: YICKECGKAFSHSASLCKHLRTH | ||||||
Zinc finger | 290-312 | C2H2-type 4 | ||||
Sequence: YTCKECGKSFSRRSGLFLHQKIH | ||||||
Zinc finger | 343-365 | C2H2-type 5 | ||||
Sequence: YLCNECGNTFKSSSSLRYHQRIH | ||||||
Zinc finger | 371-393 | C2H2-type 6 | ||||
Sequence: FKCSECGRAFSQSASLIQHERIH | ||||||
Zinc finger | 399-421 | C2H2-type 7 | ||||
Sequence: YRCSECGKGFTSISRLNRHRIIH | ||||||
Zinc finger | 427-449 | C2H2-type 8 | ||||
Sequence: YNCNECGKALSSHSTLIIHERIH | ||||||
Zinc finger | 455-477 | C2H2-type 9 | ||||
Sequence: CKCKVCGKAFRQSSALIQHQRMH | ||||||
Zinc finger | 483-505 | C2H2-type 10 | ||||
Sequence: YKCNECGKTFRCNSSLSNHQRTH | ||||||
Zinc finger | 511-533 | C2H2-type 11 | ||||
Sequence: YRCQECGMSFGQSAALIQHRRIH | ||||||
Zinc finger | 539-561 | C2H2-type 12 | ||||
Sequence: FKCNTCGKSFRQSSSLIAHQRIH | ||||||
Zinc finger | 567-589 | C2H2-type 13 | ||||
Sequence: YECSACGKLFSQRSSLTNHYRIH |
Sequence similarities
Belongs to the krueppel C2H2-type zinc-finger protein family.
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length601
- Mass (Da)68,664
- Last updated2000-05-01 v1
- Checksum4CE1540A8FF8E8B1
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF184112 EMBL· GenBank· DDBJ | AAF01034.1 EMBL· GenBank· DDBJ | mRNA | ||
AL627215 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC107400 EMBL· GenBank· DDBJ | AAI07401.1 EMBL· GenBank· DDBJ | mRNA | ||
BC107401 EMBL· GenBank· DDBJ | AAI07402.1 EMBL· GenBank· DDBJ | mRNA | ||
AK010007 EMBL· GenBank· DDBJ | BAB26638.1 EMBL· GenBank· DDBJ | mRNA |