Q9QXQ5 · WNT4_RAT

Function

function

Ligand for members of the frizzled family of seven transmembrane receptors. Plays an important role in the embryonic development of the urogenital tract and the lung. Required for normal mesenchyme to epithelium transition during embryonic kidney development. Required for the formation of early epithelial renal vesicles during kidney development. Required for normal formation of the Mullerian duct in females, and normal levels of oocytes in the ovaries. Required for normal down-regulation of 3 beta-hydroxysteroid dehydrogenase in the ovary. Required for normal lung development and for normal patterning of trachael cartilage rings.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell surface
Cellular Componentcytoplasm
Cellular Componentextracellular matrix
Cellular Componentextracellular space
Molecular Functioncytokine activity
Molecular Functionfrizzled binding
Molecular Functionreceptor ligand activity
Molecular Functiontranscription corepressor activity
Biological Processadrenal gland development
Biological Processapoptotic signaling pathway
Biological Processbranching involved in ureteric bud morphogenesis
Biological Processbranching morphogenesis of an epithelial tube
Biological Processcanonical Wnt signaling pathway
Biological Processcell differentiation
Biological Processcell fate commitment
Biological Processcellular response to estradiol stimulus
Biological Processcellular response to starvation
Biological Processcellular response to transforming growth factor beta stimulus
Biological Processembryonic epithelial tube formation
Biological Processepithelial to mesenchymal transition
Biological Processfemale gonad development
Biological Processfemale sex determination
Biological Processfibroblast growth factor receptor signaling pathway
Biological Processgamete generation
Biological Processhormone metabolic process
Biological Processimmature T cell proliferation in thymus
Biological Processkidney development
Biological Processkidney morphogenesis
Biological Processliver development
Biological Processmale gonad development
Biological Processmammary gland epithelium development
Biological Processmeiotic nuclear division
Biological Processmesenchymal to epithelial transition
Biological Processmesonephric tubule development
Biological Processmesonephros development
Biological Processmetanephric nephron development
Biological Processmetanephric nephron morphogenesis
Biological Processmetanephric tubule formation
Biological Processmetanephros development
Biological Processnegative regulation of androgen biosynthetic process
Biological Processnegative regulation of apoptotic signaling pathway
Biological Processnegative regulation of cell differentiation
Biological Processnegative regulation of cell migration
Biological Processnegative regulation of DNA-templated transcription
Biological Processnegative regulation of fibroblast growth factor receptor signaling pathway
Biological Processnegative regulation of gene expression
Biological Processnegative regulation of male gonad development
Biological Processnegative regulation of steroid biosynthetic process
Biological Processnegative regulation of testicular blood vessel morphogenesis
Biological Processnegative regulation of testosterone biosynthetic process
Biological Processnegative regulation of wound healing
Biological Processnephron development
Biological Processneuron differentiation
Biological Processnon-canonical Wnt signaling pathway
Biological Processoocyte development
Biological Processparamesonephric duct development
Biological Processpericyte cell differentiation
Biological Processpositive regulation of aldosterone biosynthetic process
Biological Processpositive regulation of bone mineralization
Biological Processpositive regulation of collagen biosynthetic process
Biological Processpositive regulation of cortisol biosynthetic process
Biological Processpositive regulation of dermatome development
Biological Processpositive regulation of DNA-templated transcription
Biological Processpositive regulation of focal adhesion assembly
Biological Processpositive regulation of MAPK cascade
Biological Processpositive regulation of meiotic nuclear division
Biological Processpositive regulation of osteoblast differentiation
Biological Processpositive regulation of stress fiber assembly
Biological Processregulation of cell-cell adhesion
Biological Processrenal vesicle formation
Biological Processrenal vesicle induction
Biological Processresponse to benzoic acid
Biological Processresponse to estradiol
Biological Processresponse to retinoic acid
Biological ProcessSertoli cell differentiation
Biological Processsex differentiation
Biological Processsmooth muscle cell differentiation
Biological Processsomatotropin secreting cell differentiation
Biological ProcessT cell differentiation in thymus
Biological Processtertiary branching involved in mammary gland duct morphogenesis
Biological Processthyroid-stimulating hormone-secreting cell differentiation
Biological Processtube morphogenesis

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein Wnt-4

Gene names

    • Name
      Wnt4
    • Synonyms
      Wnt-4

Organism names

  • Taxonomic identifier
  • Strain
    • Sprague-Dawley
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Glires > Rodentia > Myomorpha > Muroidea > Muridae > Murinae > Rattus

Accessions

  • Primary accession
    Q9QXQ5

Proteomes

Organism-specific databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation, lipidation.

TypeIDPosition(s)Description
Signal1-22
ChainPRO_000004142323-351Protein Wnt-4
Disulfide bond78↔89
Glycosylation88N-linked (GlcNAc...) asparagine
Disulfide bond128↔136
Disulfide bond138↔155
Disulfide bond206↔220
Disulfide bond208↔215
Lipidation212O-palmitoleoyl serine; by PORCN
Disulfide bond280↔311
Disulfide bond296↔306
Glycosylation297N-linked (GlcNAc...) asparagine
Disulfide bond310↔350
Disulfide bond326↔341
Disulfide bond328↔338
Disulfide bond333↔334

Post-translational modification

Palmitoleoylation is required for efficient binding to frizzled receptors. Depalmitoleoylation leads to Wnt signaling pathway inhibition.

Keywords

Proteomic databases

PTM databases

Interaction

Subunit

Interacts with PORCN (By similarity).
Interacts with PKD1 (By similarity).

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the Wnt family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.
  • Length
    351
  • Mass (Da)
    39,044
  • Last updated
    2000-05-01 v1
  • Checksum
    5F8D80C3B4502BA1
MSPRSCLRSLRLLVFAVFSAAASNWLYLAKLSSVGSISEEETCEKLKGLIQRQVQMCKRNLEVMDSVRHGAQLAIEECQYQFRNRRWNCSTLDSLPVFGKVVTQGTREAAFVYAISSAGVAFAVTRACSSGDLEKCGCDRTVHGVSPQGFQWSGCSDNIAYGVAFSQSFVDVRERSKGASSSRALMNLHNNEAGRKAILTHMRVECKCHGVSGSCEVKTCWRAVPPFRQVGHALKEKFDGATEVEPRRVGSSRALVPRNAQFKPHTDEDLVYLEPSPDFCEQDMRSGVLGTRGRTCNKTSKAIDGCELLCCGRGFHTAHVELAERCGCRFHWCCFVKCRQCQRLVEMHTCR

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A6ITD2A6ITD2_RATWnt4351

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF188608
EMBL· GenBank· DDBJ
AAF15589.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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