Results strongly suggest that there is a pivotal role for Prolyl endopeptidase (PREP) in vesicle exocytosis as well as in the physiology of mouse seminal vesicles.
POP regulates progesterone secretion by stimulating the expression of CYP11A 3beta-HSD and StAR in luteal cells. ERK signaling and downstream SF1 expression contribute to this process.
PREP regulates the function of dopamine transporter possibly by controlling the phosphorylation and transport of dopamine transporter into the striatum or synaptic membrane.
Lung ischemia-reperfusion injury causes a dysregulation of circulating Ang 2 levels and plasma PREP activity although no direct link between both phenomena could be shown.
These findings might be explained as possible alteration in brain plasticity caused by PREP deficiency which in turn affect behaviour and brain development
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