Q9QTF2 · RIR2_RSIV

Function

function

Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).

Catalytic activity

Cofactor

Fe cation (UniProtKB | Rhea| CHEBI:24875 )

Note: Binds 2 iron ions per subunit.

Features

Showing features for binding site, active site.

131220406080100120140160180200220240260280300
Type
IDPosition(s)Description
Binding site62Fe cation 1 (UniProtKB | ChEBI)
Binding site94Fe cation 1 (UniProtKB | ChEBI)
Binding site94Fe cation 2 (UniProtKB | ChEBI)
Binding site97Fe cation 1 (UniProtKB | ChEBI)
Active site101
Binding site156Fe cation 2 (UniProtKB | ChEBI)
Binding site190Fe cation 2 (UniProtKB | ChEBI)
Binding site193Fe cation 2 (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functionmetal ion binding
Molecular Functionribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor
Biological Processdeoxyribonucleotide biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ribonucleoside-diphosphate reductase small chain
  • EC number
  • Alternative names
    • Ribonucleotide reductase small subunit

Gene names

    • Name
      RR-2

Organism names

Accessions

  • Primary accession
    Q9QTF2

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001904931-312Ribonucleoside-diphosphate reductase small chain

Interaction

Subunit

Heterodimer of a large and a small chain.

Structure

3D structure databases

Family & Domains

Sequence similarities

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    312
  • Mass (Da)
    35,653
  • Last updated
    2000-05-01 v1
  • Checksum
    7D3E43D5F4F48B0B
MDRYVLRPNDPHLWAMYKKAVASFWTVEEVDLSTDVRHWTDKLTEAERRFMSHILAFFAMADGIVGDNLVCNFAKELDHIPEARAFYGFQVAIENIHAEMYTQLIITLVAKENQAALFSAAEDMPCVKAKAQWAAQWLNATHKPIATRLLAFAAVEGVMFSGSFAAIFWLKKRSLMPGLAFSNELISRDEGLHCDFACMLFRQMANKPCQDDAHQIISDAVDIETAFFREALKTPLLGMNSDSMKLYIQFVADRLLDALGYAKMYNVSNPFDFMDNISIEGKTNFFERRVSEYQRMGVFTPSSMEFTMNEEF

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB018418
EMBL· GenBank· DDBJ
BAA82755.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp