Q9QTF2 · RIR2_RSIV
- ProteinRibonucleoside-diphosphate reductase small chain
- GeneRR-2
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids312 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Ribonucleoside-diphosphate reductase holoenzyme provides the precursors necessary for viral DNA synthesis. Allows virus growth in non-dividing cells. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity).
Catalytic activity
- a 2'-deoxyribonucleoside 5'-diphosphate + [thioredoxin]-disulfide + H2O = a ribonucleoside 5'-diphosphate + [thioredoxin]-dithiol
CHEBI:73316 + RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 = CHEBI:57930 + RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3
Cofactor
Note: Binds 2 iron ions per subunit.
Features
Showing features for binding site, active site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 62 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 94 | Fe cation 1 (UniProtKB | ChEBI) | |||
Binding site | 94 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 97 | Fe cation 1 (UniProtKB | ChEBI) | |||
Active site | 101 | ||||
Binding site | 156 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 190 | Fe cation 2 (UniProtKB | ChEBI) | |||
Binding site | 193 | Fe cation 2 (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | metal ion binding | |
Molecular Function | ribonucleoside-diphosphate reductase activity, thioredoxin disulfide as acceptor | |
Biological Process | deoxyribonucleotide biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameRibonucleoside-diphosphate reductase small chain
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageViruses > Varidnaviria > Bamfordvirae > Nucleocytoviricota > Megaviricetes > Pimascovirales > Iridoviridae > Alphairidovirinae > Megalocytivirus > Infectious spleen and kidney necrosis virus
- Virus hosts
Accessions
- Primary accessionQ9QTF2
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000190493 | 1-312 | Ribonucleoside-diphosphate reductase small chain | ||
Interaction
Subunit
Heterodimer of a large and a small chain.
Sequence
- Sequence statusComplete
- Length312
- Mass (Da)35,653
- Last updated2000-05-01 v1
- Checksum7D3E43D5F4F48B0B
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AB018418 EMBL· GenBank· DDBJ | BAA82755.1 EMBL· GenBank· DDBJ | Genomic DNA |