Q9QR71 · LANA1_HHV8P

Function

function

Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472).
Promotes nuclear localization and cleavage of host STAT6 leading to constitutive activation of the IL13/STAT6 signaling pathway to promote viral latency (PubMed:28099521).
Interacts with and modulates the histone methyltransferase MLL1 complex activity, leading to its recruitment on viral DNA terminal repeats changing the dynamic of histone H3 methylated 'Lys-4'(H3K4me) profile during the initial hours following infection (PubMed:34850113).

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componenthost cell nucleus
Molecular FunctionDNA binding
Biological Processsymbiont-mediated suppression of host NF-kappaB cascade
Biological Processviral life cycle

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Protein LANA1

Gene names

    • Name
      LANA1
    • ORF names
      ORF73

Organism names

Accessions

  • Primary accession
    Q9QR71

Proteomes

Subcellular Location

Host nucleus
Note: Colocalizes with viral episomes on host chromosomes.

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004237991-1129Protein LANA1

PTM databases

Interaction

Subunit

Homooligomer (PubMed:25947153).
Interacts with host BRD2 (PubMed:16227282).
Interacts with host RELA, ELOB, ELOC and CUL5; these interactions induce the proteasomal degradation of host RELA (PubMed:21697472).
Interacts with host TRIM28 and NFE2L2/NRF2; these interactions are essential for the shutdown of lytic gene expression during the early stage of infection (PubMed:24741090, PubMed:25995248).
Interacts (via N-terminus) with host histones H2A and H2B; these interactions are essential to dock LANA1 onto chromosomes (PubMed:16469929).
Interacts with host BUB1 and PCNA (PubMed:26223641).
Interacts with host NAP1L1; this interaction is required for LANA1-dependent DNA replication (PubMed:27599637).
Interacts with components of the host MLL1 complex KMT2A and WDR5 (PubMed:34850113).

Binary interactions

Protein-protein interaction databases

Chemistry

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-988Disordered
Compositional bias24-54Basic and acidic residues
Compositional bias83-120Pro residues
Compositional bias157-187Pro residues
Compositional bias188-216Polar residues
Compositional bias291-324Basic and acidic residues
Compositional bias325-415Acidic residues
Compositional bias422-476Polar residues
Compositional bias477-526Basic and acidic residues
Compositional bias527-598Polar residues
Compositional bias599-892Acidic residues
Region1008-1129DNA-binding domain
Region1110-1129Disordered

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    1,129
  • Mass (Da)
    131,346
  • Last updated
    2000-05-01 v1
  • Checksum
    8F63855B45F79109
MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPHTLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPVSPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPPEPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWATESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKECSENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGDGNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETVEEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPHRPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQWKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSKKVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias24-54Basic and acidic residues
Compositional bias83-120Pro residues
Compositional bias157-187Pro residues
Compositional bias188-216Polar residues
Compositional bias291-324Basic and acidic residues
Compositional bias325-415Acidic residues
Compositional bias422-476Polar residues
Compositional bias477-526Basic and acidic residues
Compositional bias527-598Polar residues
Compositional bias599-892Acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF148805
EMBL· GenBank· DDBJ
AAD46501.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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