Q9QR71 · LANA1_HHV8P
- ProteinProtein LANA1
- GeneLANA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids1129 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score4/5
Function
function
Multifunctional protein that plays a role in the replication and long-term persistence of the viral episomal genome in dividing cells. Binds to mitotic chromosomes via its N-terminal region and to a 16-bp imperfect palindrome within the origin of replication (oriP) located in the viral terminal repeat (TR) through its C-terminal. Tethers viral episomes to chromosomes during mitosis. Plays a critical role in the shutdown of lytic gene expression during the early stage of infection by interacting with host TRIM28. Plays also a role in the repression of host NF-kappa-B activity upon TNF-alpha stimulation by promoting the proteasomal degradation of host RELA (PubMed:21697472).
Promotes nuclear localization and cleavage of host STAT6 leading to constitutive activation of the IL13/STAT6 signaling pathway to promote viral latency (PubMed:28099521).
Interacts with and modulates the histone methyltransferase MLL1 complex activity, leading to its recruitment on viral DNA terminal repeats changing the dynamic of histone H3 methylated 'Lys-4'(H3K4me) profile during the initial hours following infection (PubMed:34850113).
Promotes nuclear localization and cleavage of host STAT6 leading to constitutive activation of the IL13/STAT6 signaling pathway to promote viral latency (PubMed:28099521).
Interacts with and modulates the histone methyltransferase MLL1 complex activity, leading to its recruitment on viral DNA terminal repeats changing the dynamic of histone H3 methylated 'Lys-4'(H3K4me) profile during the initial hours following infection (PubMed:34850113).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell nucleus | |
Molecular Function | DNA binding | |
Biological Process | symbiont-mediated suppression of host NF-kappaB cascade | |
Biological Process | viral life cycle |
Keywords
- Molecular function
- Biological process
Names & Taxonomy
Protein names
- Recommended nameProtein LANA1
Gene names
Organism names
- Taxonomic lineageViruses > Duplodnaviria > Heunggongvirae > Peploviricota > Herviviricetes > Herpesvirales > Orthoherpesviridae > Gammaherpesvirinae > Rhadinovirus > Rhadinovirus humangamma8 > Human herpesvirus 8
- Virus hosts
Accessions
- Primary accessionQ9QR71
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
Note: Colocalizes with viral episomes on host chromosomes.
Keywords
- Cellular component
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000423799 | 1-1129 | Protein LANA1 | |||
Sequence: MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPHTLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPVSPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPPEPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWATESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKECSENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGDGNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETVEEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPHRPGVRMRRVPVTHPKKPHPRYQQPPVPYRQIDDCPAKARPQHIFYRRFLGKDGRRDPKCQWKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSKKVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT |
PTM databases
Interaction
Subunit
Homooligomer (PubMed:25947153).
Interacts with host BRD2 (PubMed:16227282).
Interacts with host RELA, ELOB, ELOC and CUL5; these interactions induce the proteasomal degradation of host RELA (PubMed:21697472).
Interacts with host TRIM28 and NFE2L2/NRF2; these interactions are essential for the shutdown of lytic gene expression during the early stage of infection (PubMed:24741090, PubMed:25995248).
Interacts (via N-terminus) with host histones H2A and H2B; these interactions are essential to dock LANA1 onto chromosomes (PubMed:16469929).
Interacts with host BUB1 and PCNA (PubMed:26223641).
Interacts with host NAP1L1; this interaction is required for LANA1-dependent DNA replication (PubMed:27599637).
Interacts with components of the host MLL1 complex KMT2A and WDR5 (PubMed:34850113).
Interacts with host BRD2 (PubMed:16227282).
Interacts with host RELA, ELOB, ELOC and CUL5; these interactions induce the proteasomal degradation of host RELA (PubMed:21697472).
Interacts with host TRIM28 and NFE2L2/NRF2; these interactions are essential for the shutdown of lytic gene expression during the early stage of infection (PubMed:24741090, PubMed:25995248).
Interacts (via N-terminus) with host histones H2A and H2B; these interactions are essential to dock LANA1 onto chromosomes (PubMed:16469929).
Interacts with host BUB1 and PCNA (PubMed:26223641).
Interacts with host NAP1L1; this interaction is required for LANA1-dependent DNA replication (PubMed:27599637).
Interacts with components of the host MLL1 complex KMT2A and WDR5 (PubMed:34850113).
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
XENO | Q9QR71 | DNMT1 P26358 | 2 | EBI-15602554, EBI-719459 | |
XENO | Q9QR71 | DNMT3A Q9Y6K1 | 3 | EBI-15602554, EBI-923653 | |
XENO | Q9QR71 | DNMT3B Q9UBC3 | 2 | EBI-15602554, EBI-80125 | |
XENO | Q9QR71 | H2AC19 Q6FI13 | 3 | EBI-15602554, EBI-353620 | |
XENO | Q9QR71 | H2BC12 O60814 | 3 | EBI-15602554, EBI-4409738 | |
XENO | Q9QR71 | H4C9 P62805 | 2 | EBI-15602554, EBI-302023 |
Protein-protein interaction databases
Chemistry
Family & Domains
Features
Showing features for region, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-988 | Disordered | ||||
Sequence: MAPPGMRLRSGRSTGAPLTRGSCRKRNRSPERCDLGDDLHLQPRRKHVADSVDGRECGPHTLPIPGSPTVFTSGLPAFVSSPTLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPVSPGTTDTHSPSPALPPTQSPESSQRPPLSSPTGRPDSSTPMRPPPSQQTTPPHSPTTPPPEPPSKSSPDSLAPSTLRSLRKRRLSSPQGPSTLNPICQSPPVSPPRCDFANRSVYPPWATESPIYVGSSSDGDTPPRQPPTSPISIGSSSPSEGSWGDDTAMLVLLAEIAEEASKNEKECSENNQAGEDNGDNEISKESQVDKDDNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDEEDGGDGNKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGVEQQEQETVEEPIILHGSSSEDEMEVDYPVVSTHEQIASSPPGDNTPDDDPQPGPSREYRYVLRTSPPHRPGVRMRRVPVTHPKKPHPRYQQPPVPY | ||||||
Compositional bias | 24-54 | Basic and acidic residues | ||||
Sequence: RKRNRSPERCDLGDDLHLQPRRKHVADSVDG | ||||||
Compositional bias | 83-120 | Pro residues | ||||
Sequence: TLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV | ||||||
Compositional bias | 157-187 | Pro residues | ||||
Sequence: SSTPMRPPPSQQTTPPHSPTTPPPEPPSKSS | ||||||
Compositional bias | 188-216 | Polar residues | ||||
Sequence: PDSLAPSTLRSLRKRRLSSPQGPSTLNPI | ||||||
Compositional bias | 291-324 | Basic and acidic residues | ||||
Sequence: EEASKNEKECSENNQAGEDNGDNEISKESQVDKD | ||||||
Compositional bias | 325-415 | Acidic residues | ||||
Sequence: DNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDE | ||||||
Compositional bias | 422-476 | Polar residues | ||||
Sequence: NKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREP | ||||||
Compositional bias | 477-526 | Basic and acidic residues | ||||
Sequence: QQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREP | ||||||
Compositional bias | 527-598 | Polar residues | ||||
Sequence: QQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQ | ||||||
Compositional bias | 599-892 | Acidic residues | ||||
Sequence: QDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGV | ||||||
Region | 1008-1129 | DNA-binding domain | ||||
Sequence: FLGKDGRRDPKCQWKFAVIFWGNDPYGLKKLSQAFQFGGVKAGPVSCLPHPGPDQSPITYCVYVYCQNKDTSKKVQMARLAWEASHPLAGNLQSSIVKFKKPLPLTQPGENQGPGDSPQEMT | ||||||
Region | 1110-1129 | Disordered | ||||
Sequence: LPLTQPGENQGPGDSPQEMT |
Family and domain databases
Sequence
- Sequence statusComplete
- Length1,129
- Mass (Da)131,346
- Last updated2000-05-01 v1
- Checksum8F63855B45F79109
Features
Showing features for compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Compositional bias | 24-54 | Basic and acidic residues | ||||
Sequence: RKRNRSPERCDLGDDLHLQPRRKHVADSVDG | ||||||
Compositional bias | 83-120 | Pro residues | ||||
Sequence: TLPVAPIPSPAPATPLPPPALLPPVTTSSSPIPPSHPV | ||||||
Compositional bias | 157-187 | Pro residues | ||||
Sequence: SSTPMRPPPSQQTTPPHSPTTPPPEPPSKSS | ||||||
Compositional bias | 188-216 | Polar residues | ||||
Sequence: PDSLAPSTLRSLRKRRLSSPQGPSTLNPI | ||||||
Compositional bias | 291-324 | Basic and acidic residues | ||||
Sequence: EEASKNEKECSENNQAGEDNGDNEISKESQVDKD | ||||||
Compositional bias | 325-415 | Acidic residues | ||||
Sequence: DNDNKDDEEEQETDEEDEEDDEEDDEEDDEEDDEEDDEEDDEEDDEEEDEEEDEEEDEEEDEEEEEDEEDDDDEDNEDEEDDEEEDKKEDE | ||||||
Compositional bias | 422-476 | Polar residues | ||||
Sequence: NKTLSIQSSQQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQREP | ||||||
Compositional bias | 477-526 | Basic and acidic residues | ||||
Sequence: QQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREPQQREP | ||||||
Compositional bias | 527-598 | Polar residues | ||||
Sequence: QQREPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQEPQQQDEQQ | ||||||
Compositional bias | 599-892 | Acidic residues | ||||
Sequence: QDEQQQDEQQQDEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQQQDEQQQDEQQQDEQQQDEQEQQDEQQQDEQQQQDEQEQQEEQEQQEEQEQQEEQEQQEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQELEEQEQEQELEEVEEQEQEQEEQELEEVEEQEQEQEEQEEQELEEVEEQEEQELEEVEEQEEQELEEVEEQEQQGV |
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF148805 EMBL· GenBank· DDBJ | AAD46501.1 EMBL· GenBank· DDBJ | Genomic DNA |