Q9Q2Q3 · POL2_BBWV2

Function

function

VP53

Acts as a suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25173697).
Binds ssRNA (PubMed:25173697).

Movement protein

Transports the viral genome to neighboring plant cells directly through plasmosdesmata, without any budding (PubMed:19463725).
The movement protein allows efficient cell to cell propagation, by bypassing the host cell wall barrier (PubMed:19463725).
Acts by forming a tubular structure at the host plasmodesmata, enlarging it enough to allow free passage of virion capsids (PubMed:20832435, PubMed:26903400).
Binds to GTP and to single-stranded RNA and single-stranded DNA in a non-sequence-specific manner (PubMed:12021864).
Also acts as a suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25173697).

Large capsid protein

Together with the small capsid protein, forms an icosahedral capsid (T=3) enclosing the viral positive strand RNA genome, with a diameter of approximately 300 Angstroms (By similarity).
The large capsid protein interacts with the viral RNA (By similarity).
Also acts as a suppressor of post-transcriptional gene silencing (PTGS), a mechanism of plant viral defense that limits the accumulation of viral RNAs (PubMed:25173697).
Binds ssRNA (PubMed:25173697).

Small capsid protein

Together with the large capsid protein, forms an icosahedral capsid (T=3) enclosing the viral positive strand RNA genome, with a diameter of approximately 300 Angstroms (By similarity).
The capsid is formed from 60 copies each of the large and the small capsid protein. The small capsid protein forms the turrets at the fivefold axes of the viral particle (By similarity).

Features

Showing features for site.

TypeIDPosition(s)Description
Site466-467Cleavage; by viral protease
Site868-869Cleavage; by viral protease

GO annotations

AspectTerm
Cellular Componenthost cell endoplasmic reticulum
Cellular Componenthost cell plasmodesma
Cellular ComponentT=3 icosahedral viral capsid
Molecular FunctionDNA binding
Molecular FunctionRNA binding
Molecular Functionstructural molecule activity
Biological Processsymbiont-mediated suppression of host innate immune response
Biological Processtransport of virus in host, cell to cell
Biological Processvirus-mediated perturbation of host defense response

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    RNA2 polyprotein
  • Alternative names
    • 119kDa protein
    • Genome polyprotein M
  • Cleaved into 4 chains

Organism names

  • Taxonomic identifier
  • Strain
    • B935
  • Taxonomic lineage
    Viruses > Riboviria > Orthornavirae > Pisuviricota > Pisoniviricetes > Picornavirales > Secoviridae > Comovirinae > Fabavirus > Fabavirus betaviciae

Accessions

  • Primary accession
    Q9Q2Q3
  • Secondary accessions
    • Q9Q2Q2

Subcellular Location

Movement protein

Note: Assembles in tubules that are embedded within modified plasmodesmata.

Large capsid protein

Virion

Small capsid protein

Virion

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004458641-466VP53
ChainPRO_00004458631-1065RNA2 polyprotein
ChainPRO_0000445865129-466Movement protein
ChainPRO_0000445866467-868Large capsid protein
ChainPRO_0000445867869-1065Small capsid protein

Post-translational modification

RNA2 polyprotein

Specific enzymatic cleavages by picornain 3C-like protease in vivo yield mature proteins.

Interaction

Subunit

Small capsid protein

Interacts with the large capsid protein (By similarity).
Interacts with the movement protein (via C-terminus) (PubMed:19463725).

Large capsid protein

Interacts with the small capsid protein (By similarity).
Homomultimer; assembles as pentons (By similarity).

Movement protein

Interacts (via C-terminus) with the small capsid protein (PubMed:19463725).

Structure

3D structure databases

Family & Domains

Domain

Movement protein

The C-terminus is important for targeting the movement protein to the plasmodesmata.

VP53

The N-terminus is involved in ssRNA-binding.

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative initiation.

Q9Q2Q3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    RNA2 polyprotein
  • Synonyms
    119kDa protein
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    1,065
  • Mass (Da)
    119,214
  • Last updated
    2000-05-01 v1
  • Checksum
    C3B9CDF05AF74A7D
MRPELVAVLDRYFSEIISCFFLGWLLNFLLVWFCSTKSTFLLWSVFLYICYYILRIEFAYIVAPFLKTIYTNSSQYHTVDWAYAYTALPKGLWEQITDYNYCYNFPPPRVEGFVSDFSPRFTLKELEIMNEANITPVHTIPKDTLLKRASDYKLAVESKKSILPRVQDLYEMDKWHNLRSKLSKNAPSYVTTSEIAVGAMSGAGNTKLAIPVVEKYTEEVADDRLPDRVRAKADQIMVAAIELVADGFASVNSDVTMAGALYDKRHKTIASSFKGAFASRASGVPSHVIYFPMHRVPACDDPNTTLELSMVSRDSDFDEGYTLANISARTLYVRAKGPEKVTETRHLLKAKTEDVVKARQFASEAQVVFATPRLFPEVNLDNYNLPGPSNAQQTEAITTDRGILFPKPKFKGNEVVLNYTGSGKIRNVGSQRFETKKNATGEQFVRSVDDLGCLSDEDGKDYRYGQGLMEEDVLNVQTNNFAIESATETMRLLFSGYASIPLNVIPGTKITVAYLNELSKHSAVHTGLLNMLSKIPGSLKVKINCQVAPTCGIGLAVSYVEGNESANLGSSLGRLLGIQHYKWNPAIEPYVEFVFKPFSCADWWNMHYLGSFKFAPVVVIQTLSKWLNAPKVDARISFAIYYEPTVVLPKQIATLEHAPAFMFRKEVGTLAFKQGERVAYSFEVNLGKPQTDGKEVTSTFASSYCGLSQYMQSDVILDFTLMSSPMIGGTFSIAYVAGAYIEKVGNMQILDSLPHIDFTFSSGSKSTRSVRFPKEVFGVYQALDRWDLDSARGDDVSGNFVLYQRDAVSSALEGELTFRIAARLSGDISFTGVSAGYPTTITRIGKGKTIGRSLDPEIRKPLRYMLGQAHATPKDFSSVRFVMGHWKYRAGLYPGSKSDEDIHPFSLKMRLDGSKSSENFEIIHSPFVRLLQNCAWMRGTLRFYVVARASSDYMSYRRTSQLTVSAHENSLSSNQFYSGVLTSPSGELSFSREVVGPVDGFASMGWNVRGSKKFYKIHVEMGNVHEYDTVVLYGQFDSNVEFAGQRKGGHYLLEKETPIFKTIKY

Q9Q2Q3-2

  • Name
    RNA2 polyprotein 104kDa
  • Synonyms
    104kDa protein
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0599831-128in isoform RNA2 polyprotein 104kDa

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AJ132844
EMBL· GenBank· DDBJ
CAB63086.1
EMBL· GenBank· DDBJ
Genomic RNA
AJ132844
EMBL· GenBank· DDBJ
CAB63085.1
EMBL· GenBank· DDBJ
Genomic RNA

Similar Proteins

Disclaimer

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