Q9PY90 · Q9PY90_I34A0
- ProteinPolymerase basic protein 2
- Genepb2
- StatusUniProtKB unreviewed (TrEMBL)
- Amino acids739 (go to sequence)
- Protein existenceEvidence at transcript level
- Annotation score2/5
Function
function
Plays an essential role in transcription initiation and cap-stealing mechanism, in which cellular capped pre-mRNAs are used to generate primers for viral transcription.
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
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Aspect | Term | |
---|---|---|
Cellular Component | host cell mitochondrion | |
Cellular Component | host cell nucleus | |
Cellular Component | virion component | |
Molecular Function | RNA binding | |
Biological Process | 7-methylguanosine mRNA capping | |
Biological Process | cap snatching | |
Biological Process | DNA-templated transcription | |
Biological Process | symbiont-mediated suppression of host mRNA transcription via inhibition of RNA polymerase II activity |
Keywords
- Biological process
Names & Taxonomy
Protein names
- Recommended namePolymerase basic protein 2
Gene names
Organism names
- Taxonomic lineageViruses > Riboviria > Orthornavirae > Negarnaviricota > Polyploviricotina > Insthoviricetes > Articulavirales > Orthomyxoviridae > Alphainfluenzavirus > Alphainfluenzavirus influenzae > Influenza A virus
- Virus hosts
Accessions
- Primary accessionQ9PY90
Subcellular Location
UniProt Annotation
GO Annotation
Keywords
- Cellular component
Interaction
Subunit
Influenza RNA polymerase is composed of three subunits: PB1, PB2 and PA.
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-25 | Influenza RNA polymerase PB2 N-terminal region | ||||
Sequence: SQSRTREILTKTTVDHMAIIKKYTS | ||||||
Domain | 26-93 | Influenza RNA polymerase PB2 second | ||||
Sequence: GRQEKNPALRMKWMMAMKYPITADKRIIEMIPEKNEQGQTLWSKTNDAGSDRVMVSPLAVTWWNRNGP | ||||||
Domain | 96-237 | Influenza RNA polymerase PB2 middle | ||||
Sequence: STVHYPKVYKTYFEKVERLKHGTFGPVHFRNQVKIRRRVDINPGHANLSAKEAQDVIMEVVFPNEVGARILTSESQLTITREKKEELQDCKIAPLMVAYMLERELVRKTRFLPVAGGTSSVYIEVLHLTQGTCWEQMYTPGG | ||||||
Domain | 239-308 | Polymerase basic protein 2 helical | ||||
Sequence: VRNDDVDQSLIIAARNIVRRATVSADPLASLLEMCHSTQIGGIKMVDILRQNPTEEQAVDICKAAMGLRI | ||||||
Domain | 309-519 | Influenza RNA polymerase PB2 CAP binding | ||||
Sequence: SSSFSFGGFTFKRTSGSSVNRKEEVLTGNLQTLKIRVHEGYEEFTMVGRRATAILRKATRRLIQLIVSGRDEQSIAEAVIVAMVFSQEDCMIKAVRGDLNFVNRANQRLNPMHQLLRHFQKDAKTLFQNWGIEPIDNVMGMIGILPDMTPSTEMSLRGVRVSKMGVDEYSSTERVVVSIDRFLRVRDQRGNVLLSPEEVSETQGTEKLTIT | ||||||
Domain | 520-667 | Influenza RNA polymerase PB2 sixth | ||||
Sequence: YSSSMMWEINGPESVLVNTYQWIIRNWETVKIQWSQVPAILYNKMEFEPFQSLVPKAARGQYSGFVRTLFQQMRDVLGTFDTVQIIKLLPFAAAPPEQSRMQFSSLTVNVRGSGMRILVRGNSPVFNYNKATKRLTVLGKDAGALTED | ||||||
Domain | 672-739 | Influenza RNA polymerase PB2 C-terminal | ||||
Sequence: TAGVESAVLRGFLILGKEDKRYGPALSINELSNLAKGEKANVLIGQGDVVLVMKRKRDSSILTDSQTA |
Sequence similarities
Belongs to the influenza viruses PB2 family.
Family and domain databases
Sequence
- Sequence statusFragment
- Length739
- Mass (Da)83,212
- Last updated2000-05-01 v1
- Checksum617034D126A08A24
Features
Showing features for non-terminal residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-terminal residue | 1 | |||||
Sequence: S | ||||||
Non-terminal residue | 739 | |||||
Sequence: A |