Q9PWR3 · PITX2_XENLA

Function

function

Involved in left-right asymmetry of the developing embryo (PubMed:10585561).
May play an important role in development and maintenance of anterior structures. Could play a role at the interface of lateral plate signaling and heart and gut morphogenesis

Features

Showing features for dna binding.

132650100150200250300
TypeIDPosition(s)Description
DNA binding94-153Homeobox

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Biological Processembryonic organ morphogenesis
Biological Processheart morphogenesis

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Pituitary homeobox 2
  • Alternative names
    • Homeobox protein PITX2
    • Paired-like homeodomain transcription factor 2
    • xPtx2

Gene names

    • Name
      pitx2
    • Synonyms
      ptx2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q9PWR3
  • Secondary accessions
    • O93396
    • Q9YHA4

Proteomes

    • Identifier
    • Component
      Chromosome 1L, Chromosome 1S

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000492281-326Pituitary homeobox 2

Expression

Induction

By nodal/nr-1 in the left lateral plate mesoderm.

Developmental stage

Asymmetrically expressed in the left lateral plate mesoderm, tubular heart and early gut tube.

Gene expression databases

    • 373586Expressed in muscle tissue and 7 other cell types or tissues

Structure

Family & Domains

Features

Showing features for region, compositional bias, motif.

TypeIDPosition(s)Description
Region17-37Disordered
Region58-106Disordered
Compositional bias66-92Basic and acidic residues
Motif288-301OAR
Motif294-298Nuclear localization signal

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoform

Align isoforms (2)
  • Sequence status
    Complete

This entry describes 2 isoforms produced by Alternative splicing.

Q9PWR3-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    PTX2A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    326
  • Mass (Da)
    36,339
  • Last updated
    2000-05-01 v1
  • Checksum
    74366F0E4FB48E73
MNSMKEPLHLDHLAGSRVAAASSHHHHHHHHQHQTVTLVSMASSLGQRSGECKSRLEVHTISDTSSPDTADKDKSHQTKNEDSSTDDPSKKKRQRRQRTHFTSQQLQELEATFQRNRYPDMSTREEIAVWTNLTEARVRVWFKNRRAKWRKRERNQQAELCKNGFGPQFNGLMQPYDDMYPSYSYNNWAAKGLTSASLSTKSFPFFNSMNVNPLSSQSMFSSPNSISSMSMSSGMVPSAVTGVPGSGLNSLNNLNNLSNPSLNTAVPTSACPYAPPTPPYVYRDTCNSSLASLRLKAKQHSSFGYATVQTPGSNLSACQYAVDRPV

Q9PWR3-2

  • Name
    PTX2B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-70: MNSMKEPLHLDHLAGSRVAAASSHHHHHHHHQHQTVTLVSMASSLGQRSGECKSRLEVHTISDTSSPDTA → MDSNCRKLVTTCVQLGVQPSAVECLFSKESDMKKGGFSAADGTEGNRKETGKRFSRIHQSGS

Features

Showing features for alternative sequence, compositional bias, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0022701-70in isoform PTX2B
Compositional bias66-92Basic and acidic residues
Sequence conflict78in Ref. 2; CAA06697
Sequence conflict83in Ref. 2; CAA06697
Sequence conflict158in Ref. 2; CAA06697
Sequence conflict190in Ref. 2; CAA06697
Sequence conflict306-307in Ref. 2; CAA06697
Sequence conflict310in Ref. 2; CAA06697
Sequence conflict323in Ref. 1; AAC29426

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF077767
EMBL· GenBank· DDBJ
AAC29426.1
EMBL· GenBank· DDBJ
mRNA
AJ005786
EMBL· GenBank· DDBJ
CAA06696.1
EMBL· GenBank· DDBJ
mRNA
AJ005787
EMBL· GenBank· DDBJ
CAA06697.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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