Q9PUN2 · SMUF1_XENLA

Function

function

E3 ubiquitin-protein ligase that acts as a negative regulator of BMP signaling pathway. Mediates ubiquitination and degradation of smad1 and smad5, 2 receptor-regulated SMADs specific for the BMP pathway. Promotes ubiquitination and subsequent proteasomal degradation of TRAF family members and rhoa. May play a role in dendrite formation by melanocytes.

Catalytic activity

  • S-ubiquitinyl-[E2 ubiquitin-conjugating enzyme]-L-cysteine + [acceptor protein]-L-lysine = [E2 ubiquitin-conjugating enzyme]-L-cysteine + N6-ubiquitinyl-[acceptor protein]-L-lysine.
    EC:2.3.2.26 (UniProtKB | ENZYME | Rhea)

Pathway

Protein modification; protein ubiquitination.

Features

Showing features for active site.

1731100200300400500600700
TypeIDPosition(s)Description
Active site699Glycyl thioester intermediate

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytoplasm
Cellular Componentplasma membrane
Molecular Functionubiquitin protein ligase activity
Molecular Functionubiquitin-protein transferase activity
Biological ProcessBMP signaling pathway
Biological Processcell differentiation
Biological Processectoderm development
Biological Processnegative regulation of BMP signaling pathway
Biological Processproteasome-mediated ubiquitin-dependent protein catabolic process
Biological Processprotein modification process
Biological Processprotein polyubiquitination
Biological Processubiquitin-dependent protein catabolic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    E3 ubiquitin-protein ligase SMURF1
  • EC number
  • Short names
    xSMURF1
  • Alternative names
    • HECT-type E3 ubiquitin transferase SMURF1
    • SMAD ubiquitination regulatory factor 1
    • SMAD-specific E3 ubiquitin-protein ligase 1

Gene names

    • Name
      smurf1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Amphibia > Batrachia > Anura > Pipoidea > Pipidae > Xenopodinae > Xenopus > Xenopus

Accessions

  • Primary accession
    Q9PUN2
  • Secondary accessions
    • Q6GPK6

Proteomes

Organism-specific databases

Subcellular Location

Cytoplasm
Cell membrane
; Peripheral membrane protein

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001203281-731E3 ubiquitin-protein ligase SMURF1

Expression

Developmental stage

Expressed from the egg stage to the swimming tadpole, with maximum levels observed in the stages from egg to gastrula. At gastrulation distributed uniformly in embryonic ectoderm and involuting mesoderm, and expression gradually localizes to the nervous system. At early tadpole stages expressed in the CNS, eye, branchial arches, kidney and somites.

Interaction

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain1-120C2
Region210-235Disordered
Domain233-266WW 1
Domain279-312WW 2
Domain394-731HECT

Domain

The C2 domain mediates membrane localization and substrate selection.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    731
  • Mass (Da)
    83,259
  • Last updated
    2000-05-01 v1
  • Checksum
    3CE88E512A42CE2C
MSNVVTRRGGSSIRVRLTVLCAKNLAKRDFFRLPDPFAKIVVDGSGQCHSTDTVKNTLDPKWNQHYDLYVGKMDSITISIWNHKKIHKKQGAGFLGCVRLLSNAISRLKDTGYQRLDLCKLNPTDNDAVRGQIVVSLQTRDRIGTLGSVVDCRGLLDNEGALLEDTGPGRPLSCFMDEPAPYTDGPGAAGGGPGRLVESPGQEQRLQAQRVRGPEVREHVQTPQNRSHGFQSQDLPEGYEQRTTVQGQVYFLHTQTGVSTWHDPRIPRDLNSVNCDDLGSLPAGWEVRTTVSGRIYFVDHNNRTTQFTDPRLHHIINHQSQLKEPNHAIPVQSDGSLEDGDEFPAQRYERDLVQKLKVLRHELSLLQPQAGHCRVEVSREEIFEESYRQIMKMRPKDLKKRLMVKFRGEEGLDYGGVAREWLYLLCHEMLNPYYGLFQYSTDNIYTLQINPDSSINPDHLSYFHFVGRIMGLAVFHGHYINGGFTVPFYKQLLGKPIQLSDLESVDPELHKSLVWILENDITSVLDHTFCVEHNAFGRLLQHELKPNGKNLQVTEENKKEYVRLYVNWRFMRGIEAQFLALQKGFNELIPQHLLKPFEQKELELIIGGLDKIDISDWKANTRLKHCLANSNIVQWFWQAVESFDEERRARLLQFVTGSTRVPLQGFKALQGSTGAAGPRLFTIHLIDANTDNLPKAHTCFNRIDIPPYESYEKLYEKLLTAVEETSGFAVE

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF169310
EMBL· GenBank· DDBJ
AAD52564.1
EMBL· GenBank· DDBJ
mRNA
BC073111
EMBL· GenBank· DDBJ
AAH73111.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

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