Q9PTE6 · TPST1_DANRE

Function

function

Catalyzes the O-sulfation of tyrosine residues within acidic motifs of polypeptides, using 3'-phosphoadenylyl sulfate (PAPS) as cosubstrate.

Catalytic activity

Features

Showing features for binding site, active site, site.

135550100150200250300350
TypeIDPosition(s)Description
Binding site76-803'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Active site97Proton donor/acceptor
Site156Transition state stabilizer
Binding site1813'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site1893'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site1933'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site2353'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Site282Transition state stabilizer
Binding site282-2913'-phosphoadenylyl sulfate (UniProtKB | ChEBI)
Binding site2973'-phosphoadenylyl sulfate (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular ComponentGolgi apparatus
Cellular ComponentGolgi membrane
Molecular Functionprotein-tyrosine sulfotransferase activity
Biological Processpost-translational protein modification

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Protein-tyrosine sulfotransferase 1
  • EC number
  • Alternative names
    • Tyrosylprotein sulfotransferase 1 (TPST-1)

Gene names

    • Name
      tpst1

Organism names

  • Taxonomic identifier
  • Strain
    • AB
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Actinopterygii > Neopterygii > Teleostei > Ostariophysi > Cypriniformes > Danionidae > Danioninae > Danio

Accessions

  • Primary accession
    Q9PTE6
  • Secondary accessions
    • Q804S9

Proteomes

    • Identifier
    • Component
      Alternate scaffold 15, Chromosome 15

Organism-specific databases

Subcellular Location

Golgi apparatus membrane
; Single-pass type II membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain1-8Cytoplasmic
Transmembrane9-25Helical; Signal-anchor for type II membrane protein
Topological domain26-355Lumenal

Keywords

PTM/Processing

Features

Showing features for chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
ChainPRO_00001898281-355Protein-tyrosine sulfotransferase 1
Glycosylation55N-linked (GlcNAc...) asparagine
Disulfide bond94↔154
Disulfide bond223↔230

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region99-103Interaction with peptide substrate
Region325-355Disordered

Sequence similarities

Belongs to the protein sulfotransferase family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    355
  • Mass (Da)
    40,198
  • Last updated
    2005-02-01 v2
  • Checksum
    02F45B99C9C7E502
MIGKLKQNLLVACLVISSVTVFYLCRHAMDCHHRIEERSQPLLSSLHATLRTGQNLSTPFIYNKDMPLIFIGGVPRSGTTLMRAMLDAHPDVRCGEETRVIPRILAMKQMWSRSGREKMRLDEAGVTDEVLDSAMQAFLLEIIVKHGEPANYLCNKDPFALKSLTYLAKIFPHAKFILMVRDGRASVHSMISRKVTIAGFDLSSYRDCLTKWNRAIETMYTQCLEAADKCLPVHYEQLVLHPEKWMRTLLRFLNIPWNDAVLHHEELIGKAGGVSLSKVERSTDQVIKPVNVEALSKWVGKIPLDVQRDMAVIAPMLARLGYDPHANPPNYGRPDPLVLDNTRRLQKSPEKPNPS

Computationally mapped potential isoform sequences

There is 1 potential isoform mapped to this entry

View all
EntryEntry nameGene nameLength
A0A0R4IQR2A0A0R4IQR2_DANREtpst1372

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict211in Ref. 3; AAF18448

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF510736
EMBL· GenBank· DDBJ
AAO42986.1
EMBL· GenBank· DDBJ
mRNA
BC056786
EMBL· GenBank· DDBJ
AAH56786.1
EMBL· GenBank· DDBJ
mRNA
AF204241
EMBL· GenBank· DDBJ
AAF18448.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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