Q9PNE6 · GMHA1_CAMJE

Function

function

Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.

Miscellaneous

The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.

Catalytic activity

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Note: Binds 1 zinc ion per subunit.

Pathway

Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Bacterial outer membrane biogenesis; LOS core biosynthesis.

Features

Showing features for binding site.

TypeIDPosition(s)Description
Binding site48-50substrate
Binding site57Zn2+ (UniProtKB | ChEBI)
Binding site61substrate
Binding site61Zn2+ (UniProtKB | ChEBI)
Binding site90-91substrate
Binding site116-118substrate
Binding site121substrate
Binding site168substrate
Binding site168Zn2+ (UniProtKB | ChEBI)
Binding site176Zn2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functioncarbohydrate derivative binding
Molecular FunctionD-sedoheptulose 7-phosphate isomerase activity
Molecular Functionzinc ion binding
Biological Processcarbohydrate metabolic process
Biological ProcessD-glycero-D-manno-heptose 7-phosphate biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Phosphoheptose isomerase 1
  • EC number
  • Alternative names
    • Sedoheptulose 7-phosphate isomerase 1

Gene names

    • Name
      gmhA1
    • Synonyms
      gmhA
    • Ordered locus names
      Cj1149c

Organism names

Accessions

  • Primary accession
    Q9PNE6
  • Secondary accessions
    • Q0P9A7
    • Q6TG10
    • Q7BPS4

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001365221-186Phosphoheptose isomerase 1

Proteomic databases

Interaction

Subunit

Homotetramer.

Protein-protein interaction databases

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain33-186SIS

Sequence similarities

Belongs to the SIS family. GmhA subfamily.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    186
  • Mass (Da)
    20,085
  • Last updated
    2000-10-01 v1
  • Checksum
    D7759471EC88924D
MINLVEKEWQEHQKIVQASEILKGQIAKVGELLCECLKKGGKILICGNGGSAADAQHFAAELSGRYKKERKALAGIALTTDTSALSAIGNDYGFEFVFSRQVEALGNEKDVLIGISTSGKSPNVLEALKKAKELNMLCLGLSGKGGGMMNKLCDHNLVVPSDDTARIQEMHILIIHTLCQIIDESF

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict16in Ref. 2; AAR82882
Sequence conflict18in Ref. 1; AAR99164 and 2; AAR82882
Sequence conflict31in Ref. 1; AAR99164
Sequence conflict109in Ref. 1; AAR99164 and 2; AAR82882
Sequence conflict128in Ref. 1; AAR99164 and 2; AAR82882

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF167344
EMBL· GenBank· DDBJ
AAR99164.1
EMBL· GenBank· DDBJ
Genomic DNA
AY422197
EMBL· GenBank· DDBJ
AAR82882.1
EMBL· GenBank· DDBJ
Genomic DNA
AL111168
EMBL· GenBank· DDBJ
CAL35264.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

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