Q9PNE6 · GMHA1_CAMJE
- ProteinPhosphoheptose isomerase 1
- GenegmhA1
- StatusUniProtKB reviewed (Swiss-Prot)
- Amino acids186 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score3/5
Function
function
Catalyzes the isomerization of sedoheptulose 7-phosphate in D-glycero-D-manno-heptose 7-phosphate.
Miscellaneous
The reaction produces a racemic mixture of D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate.
Catalytic activity
- 2 D-sedoheptulose 7-phosphate = D-glycero-alpha-D-manno-heptose 7-phosphate + D-glycero-beta-D-manno-heptose 7-phosphate
Cofactor
Note: Binds 1 zinc ion per subunit.
Pathway
Carbohydrate biosynthesis; D-glycero-D-manno-heptose 7-phosphate biosynthesis; D-glycero-alpha-D-manno-heptose 7-phosphate and D-glycero-beta-D-manno-heptose 7-phosphate from sedoheptulose 7-phosphate: step 1/1.
Bacterial outer membrane biogenesis; LOS core biosynthesis.
Features
Showing features for binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Binding site | 48-50 | substrate | |||
Binding site | 57 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 61 | substrate | |||
Binding site | 61 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 90-91 | substrate | |||
Binding site | 116-118 | substrate | |||
Binding site | 121 | substrate | |||
Binding site | 168 | substrate | |||
Binding site | 168 | Zn2+ (UniProtKB | ChEBI) | |||
Binding site | 176 | Zn2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Molecular Function | carbohydrate derivative binding | |
Molecular Function | D-sedoheptulose 7-phosphate isomerase activity | |
Molecular Function | zinc ion binding | |
Biological Process | carbohydrate metabolic process | |
Biological Process | D-glycero-D-manno-heptose 7-phosphate biosynthetic process |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended namePhosphoheptose isomerase 1
- EC number
- Alternative names
Gene names
Organism names
- Strains
- Taxonomic lineageBacteria > Campylobacterota > Epsilonproteobacteria > Campylobacterales > Campylobacteraceae > Campylobacter
Accessions
- Primary accessionQ9PNE6
- Secondary accessions
Proteomes
Subcellular Location
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000136522 | 1-186 | Phosphoheptose isomerase 1 | ||
Proteomic databases
Structure
Sequence
- Sequence statusComplete
- Length186
- Mass (Da)20,085
- Last updated2000-10-01 v1
- ChecksumD7759471EC88924D
Features
Showing features for sequence conflict.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Sequence conflict | 16 | in Ref. 2; AAR82882 | |||
Sequence conflict | 18 | in Ref. 1; AAR99164 and 2; AAR82882 | |||
Sequence conflict | 31 | in Ref. 1; AAR99164 | |||
Sequence conflict | 109 | in Ref. 1; AAR99164 and 2; AAR82882 | |||
Sequence conflict | 128 | in Ref. 1; AAR99164 and 2; AAR82882 | |||
Keywords
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF167344 EMBL· GenBank· DDBJ | AAR99164.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AY422197 EMBL· GenBank· DDBJ | AAR82882.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AL111168 EMBL· GenBank· DDBJ | CAL35264.1 EMBL· GenBank· DDBJ | Genomic DNA |