Q9PKI5 · KDTA_CHLMU

Function

function

Involved in lipopolysaccharide (LPS) biosynthesis. Catalyzes the transfer of three 3-deoxy-D-manno-octulosonate (Kdo) residues from CMP-Kdo to lipid IV(A), the tetraacyldisaccharide-1,4'-bisphosphate precursor of lipid A. Thus generates the genus-specific LPS epitope of Chlamydia, composed of the trisaccharide alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo.

Catalytic activity

Pathway

Bacterial outer membrane biogenesis; LPS core biosynthesis.

Features

Showing features for active site, site, binding site.

TypeIDPosition(s)Description
Active site66Proton acceptor
Site137Transition state stabilizer
Site215Transition state stabilizer
Binding site274-275CMP (UniProtKB | ChEBI)
Binding site314-316CMP (UniProtKB | ChEBI)
Binding site341-344CMP (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentplasma membrane
Molecular FunctionKdo transferase activity
Biological Processlipopolysaccharide core region biosynthetic process

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    3-deoxy-D-manno-octulosonic acid transferase
  • EC number
  • Short names
    Kdo transferase
  • Alternative names
    • Kdo(2)-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
    • Kdo-lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase
    • Lipid IV(A) 3-deoxy-D-manno-octulosonic acid transferase

Gene names

    • Name
      waaA
    • Synonyms
      kdtA
    • Ordered locus names
      TC_0480

Organism names

Accessions

  • Primary accession
    Q9PKI5

Proteomes

Subcellular Location

Cell inner membrane
; Single-pass membrane protein

Features

Showing features for transmembrane.

TypeIDPosition(s)Description
Transmembrane12-32Helical; Signal-anchor

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00000802821-4303-deoxy-D-manno-octulosonic acid transferase

Structure

Family & Domains

Sequence similarities

Keywords

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    430
  • Mass (Da)
    48,858
  • Last updated
    2000-10-01 v1
  • Checksum
    FCB828B9FA796C8A
MRRWLTSRLYDAFLVAAFLAAAPRIFYKVVFHGKYINSWKIRFGVEKPQVKGEGPLVWFHGASVGEVSLLEPLLKKWRQEFPDWRFVVTACSEAGVYTAQRLYAPLGATVFVLPLDLSCIINPVVRSLSPQVVIFSEGDCWLHFLMGAKKLGAKAFLINGKLSENSCKRFAFLKRLGRSYFAPLDLLVLQDKVYKQRFMQIGIPEDKIQISGNLKTFIETETSINNRSLWRKKLKLSPSDRLIVLGSMHPKDVEVWADVAQHFNKFSTKILWVPRHLEKLKEHARLLEKAGISFGLWSKEDSLLQYDSLIVDAMGILKDLYSAADLAFVGGTFDPLVGGHNLLEPLQKEVPLMFGPHIHSQSVLAELLRTKEVGVSVDKENLLEAVENLLEDEKKRQAYIERGKSFLKNAGTSFEHTWEILKSQIACIKI

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE002160
EMBL· GenBank· DDBJ
AAF39326.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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