Q9PEN0 · AOTC_XYLFA

Function

function

Catalyzes the transfer of the carbamoyl group from carbamoyl phosphate to the delta-amino group of N2-acetyl-L-ornithine to produce N2-acetyl-L-citrulline. This is a step in an alternative arginine biosynthesis pathway. The enzyme has no activity with ornithine.

Catalytic activity

Activity regulation

Carboxylation at Lys-302 increases the catalytic activity of the enzyme.

Pathway

Amino-acid biosynthesis; L-arginine biosynthesis.

Features

Showing features for binding site, site.

TypeIDPosition(s)Description
Binding site49-52carbamoyl phosphate (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site77carbamoyl phosphate (UniProtKB | ChEBI); ligand shared between two neighboring subunits
Site92Key residue in conferring substrate specificity for N-acetyl-L-ornithine versus N-succinyl-L-ornithine
Binding site112carbamoyl phosphate (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site144N2-acetyl-L-ornithine (UniProtKB | ChEBI)
Binding site148-151carbamoyl phosphate (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site252N2-acetyl-L-ornithine (UniProtKB | ChEBI)
Binding site294-295carbamoyl phosphate (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain
Binding site295N2-acetyl-L-ornithine (UniProtKB | ChEBI)
Binding site322carbamoyl phosphate (UniProtKB | ChEBI); ligand shared between two neighboring subunits; in other chain

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular Functionamino acid binding
Molecular FunctionN-acetylornithine carbamoyltransferase activity
Molecular Functionornithine carbamoyltransferase activity
Biological Processarginine biosynthetic process via ornithine
Biological Processcitrulline biosynthetic process

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    N-acetylornithine carbamoyltransferase
  • EC number
  • Alternative names
    • N-acetyl-L-ornithine transcarbamylase
      (AOTCase
      ; Acetylornithine transcarbamylase
      )

Gene names

    • Name
      argF'
    • Ordered locus names
      XF_0998

Organism names

Accessions

  • Primary accession
    Q9PEN0

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, modified residue.

TypeIDPosition(s)Description
ChainPRO_00001132691-336N-acetylornithine carbamoyltransferase
Modified residue302N6-carboxylysine

Interaction

Subunit

Homotrimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    336
  • Mass (Da)
    37,623
  • Last updated
    2000-10-01 v1
  • Checksum
    5B909F441AA37438
MALKHFLNTQDWSCSELNALLTQARAFKHNKLGNGLKGKSIALVFFNASMRTRSSFELGAFQLGGHAIVLQPGKDAWPIEFDTGTVMEAETEEHICEVARVLGHYVDLIGVRAFPKFLDWTYDRQDIVLNGFAKYSPVPVINMETITHPCQELAHIMALQEHFGTTDLRGKKYVLTWTYHPKPLNTAVANSALTIATRLGMDVTLLCPTPDYVLDERYIDWAQQNIADTGSTFQVSHDIDNAYRGADVIYAKSWGALPFFGNWAMEKPIRDQYRHFIVDEAKMALTNNAVFSHCLPLRRNVKATDAVMDGPNCIAIHEAGNRLHVQKAIMAALASQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE003849
EMBL· GenBank· DDBJ
AAF83808.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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