Q9PEH8 · UPPS_XYLFA
- ProteinDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
- GeneuppS
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids255 (go to sequence)
- Protein existenceInferred from homology
- Annotation score3/5
Function
function
Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
Catalytic activity
- 8 isopentenyl diphosphate + (2E,6E)-farnesyl diphosphate = di-trans,octa-cis-undecaprenyl diphosphate + 8 diphosphate
Cofactor
Note: Binds 2 magnesium ions per subunit.
Features
Showing features for active site, binding site.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Active site | 21 | ||||
Binding site | 21 | Mg2+ (UniProtKB | ChEBI) | |||
Binding site | 22-25 | substrate | |||
Binding site | 26 | substrate | |||
Binding site | 34 | substrate | |||
Binding site | 38 | substrate | |||
Binding site | 66-68 | substrate | |||
Active site | 69 | Proton acceptor | |||
Binding site | 70 | substrate | |||
Binding site | 72 | substrate | |||
Binding site | 189 | substrate | |||
Binding site | 195-197 | substrate | |||
Binding site | 208 | Mg2+ (UniProtKB | ChEBI) | |||
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | cytosol | |
Molecular Function | di-trans,poly-cis-undecaprenyl-diphosphate synthase activity | |
Molecular Function | magnesium ion binding | |
Molecular Function | polyprenyltransferase activity | |
Biological Process | cell wall organization | |
Biological Process | peptidoglycan biosynthetic process | |
Biological Process | polyprenol biosynthetic process | |
Biological Process | regulation of cell shape |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameDitrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
- EC number
- Alternative names
Gene names
Organism names
- Organism
- Strain
- Taxonomic lineageBacteria > Pseudomonadota > Gammaproteobacteria > Lysobacterales > Lysobacteraceae > Xylella
Accessions
- Primary accessionQ9PEH8
Proteomes
Subcellular Location
UniProt Annotation
GO Annotation
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | ||
---|---|---|---|---|---|
Chain | PRO_0000123721 | 1-255 | Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific) | ||
Interaction
Structure
Sequence
- Sequence statusComplete
- Length255
- Mass (Da)28,932
- Last updated2000-10-01 v1
- Checksum5FCF47341CB89D78
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AE003849 EMBL· GenBank· DDBJ | AAF83860.1 EMBL· GenBank· DDBJ | Genomic DNA |