Q9PEH8 · UPPS_XYLFA

  • Protein
    Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
  • Gene
    uppS
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Inferred from homology
  • Annotation score
    3/5

Function

function

Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di-trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.

Catalytic activity

Cofactor

Mg2+ (UniProtKB | Rhea| CHEBI:18420 )

Note: Binds 2 magnesium ions per subunit.

Features

Showing features for active site, binding site.

Type
IDPosition(s)Description
Active site21
Binding site21Mg2+ (UniProtKB | ChEBI)
Binding site22-25substrate
Binding site26substrate
Binding site34substrate
Binding site38substrate
Binding site66-68substrate
Active site69Proton acceptor
Binding site70substrate
Binding site72substrate
Binding site189substrate
Binding site195-197substrate
Binding site208Mg2+ (UniProtKB | ChEBI)

GO annotations

AspectTerm
Cellular Componentcytosol
Molecular Functiondi-trans,poly-cis-undecaprenyl-diphosphate synthase activity
Molecular Functionmagnesium ion binding
Molecular Functionpolyprenyltransferase activity
Biological Processcell wall organization
Biological Processpeptidoglycan biosynthetic process
Biological Processpolyprenol biosynthetic process
Biological Processregulation of cell shape

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)
  • EC number
  • Alternative names
    • Ditrans,polycis-undecaprenylcistransferase
    • Undecaprenyl diphosphate synthase
      (UDS
      )
    • Undecaprenyl pyrophosphate synthase
      (UPP synthase
      )

Gene names

    • Name
      uppS
    • Ordered locus names
      XF_1050

Organism names

Accessions

  • Primary accession
    Q9PEH8

Proteomes

Subcellular Location

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001237211-255Ditrans,polycis-undecaprenyl-diphosphate synthase ((2E,6E)-farnesyl-diphosphate specific)

Interaction

Subunit

Homodimer.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the UPP synthase family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    255
  • Mass (Da)
    28,932
  • Last updated
    2000-10-01 v1
  • Checksum
    5FCF47341CB89D78
MQINTIPVNPTLPRHIAIIMDGNGRWAERRSRPRTTGHRAGVKAAMRTVDFCLEKGIKMLTLFAFSSENWNRPADEVNFLMEMSIKLFGRGIEELHRRGVQVRFIGERKRFDIALVEHMTKAEHLTANNQRLILSLAVSYGGRQDITMAARALAQDVAAGRLKPEQIDEDLLGQHMALADLPPPDMFIRTSGVIRISNFLLWQIAYTELWFTDVMWPEFNSTVLQQALDDYASRERRFGLTNAQIASRGKGSIPA

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE003849
EMBL· GenBank· DDBJ
AAF83860.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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