Q9PDD9 · MNMA_XYLFA

Function

function

Catalyzes the 2-thiolation of uridine at the wobble position (U34) of tRNA, leading to the formation of s2U34.

Features

Showing features for binding site, active site, site.

137950100150200250300350
Type
IDPosition(s)Description
Binding site9-16ATP (UniProtKB | ChEBI)
Binding site35ATP (UniProtKB | ChEBI)
Active site99Nucleophile
Binding site123ATP (UniProtKB | ChEBI)
Site124Interaction with tRNA
Active site195Cysteine persulfide intermediate
Site340Interaction with tRNA

GO annotations

AspectTerm
Cellular Componentcytoplasm
Molecular FunctionATP binding
Molecular FunctiontRNA binding
Molecular FunctiontRNA-uridine 2-sulfurtransferase activity
Biological ProcesstRNA wobble position uridine thiolation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    tRNA-specific 2-thiouridylase MnmA
  • EC number

Gene names

    • Name
      mnmA
    • Synonyms
      trmU
    • Ordered locus names
      XF_1440

Organism names

Accessions

  • Primary accession
    Q9PDD9

Proteomes

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain, disulfide bond.

Type
IDPosition(s)Description
ChainPRO_00001217051-379tRNA-specific 2-thiouridylase MnmA
Disulfide bond99↔195Alternate

Keywords

Interaction

Protein-protein interaction databases

Structure

Family & Domains

Features

Showing features for region.

TypeIDPosition(s)Description
Region94-96Interaction with target base in tRNA
Region145-147Interaction with tRNA
Region307-308Interaction with tRNA

Sequence similarities

Belongs to the MnmA/TRMU family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    379
  • Mass (Da)
    42,975
  • Last updated
    2000-10-01 v1
  • Checksum
    EF0DEA153D1F377C
MNTPRIIVAMSGGVDSSVAAWRLNSQRETIAGLFMRNWTDDGNGQCHAEEDRRDAVAVCGILGIAFHFRDFSHEYWQEVFTHFLAEYANGRTPNPDVLCNREIKFKHFLETARELGADSIATGHYARIKHYRQRWHLLRGADRSKDQSYFLHQLGQEQLAATMFPIGDLEKPQLRQLAHQAGLPTHAKKDSTGICFIGERNFREFLKQYLPAQPGEIRDPQEQRIAEHPGVFYFTLGQRQGLNIGGVRNRPPSPWYVIGKDLATNVLYVDQHRDSPFLQSRWLRSEPAHWVSGSPPAPTFTCTAQTRYRQADEPCKVTVRNDGSLDVDFTQTQWAVTPGQSLVLYDGNECLGGAVIATTDAPLERKRARNLSKTENVLQ

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AE003849
EMBL· GenBank· DDBJ
AAF84249.1
EMBL· GenBank· DDBJ
Genomic DNA

Genome annotation databases

Similar Proteins

Disclaimer

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