Q9P6I2 · DUG1_SCHPO

Function

function

Catalytic component of the GSH degradosomal complex involved in the degradation of glutathione (GSH) and other peptides containing a gamma-glu-X bond. Has a Gly-Cys dipeptidase activity.

Cofactor

Zn2+ (UniProtKB | Rhea| CHEBI:29105 )

Mn2+ (UniProtKB | Rhea| CHEBI:29035 )

Features

Showing features for binding site, active site.

147650100150200250300350400450
TypeIDPosition(s)Description
Binding site99Zn2+ 2 (UniProtKB | ChEBI)
Active site101
Binding site133Zn2+ 1 (UniProtKB | ChEBI)
Binding site133Zn2+ 2 (UniProtKB | ChEBI)
Active site167Proton acceptor
Binding site168Zn2+ 1 (UniProtKB | ChEBI)
Binding site196Zn2+ 2 (UniProtKB | ChEBI)
Binding site446Zn2+ 1 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcytosol
Cellular Componentnucleus
Molecular Functionmetal ion binding
Molecular Functionmetallodipeptidase activity
Molecular Functionpeptidase activity
Biological Processglutathione catabolic process
Biological Processproteolysis

Keywords

Enzyme and pathway databases

Protein family/group databases

Names & Taxonomy

Protein names

  • Recommended name
    Cys-Gly metallodipeptidase dug1
  • EC number
  • Alternative names
    • GSH degradosomal complex subunit DUG1

Gene names

    • Name
      dug1
    • ORF names
      SPBC1198.08

Organism names

Accessions

  • Primary accession
    Q9P6I2
  • Secondary accessions
    • P78801

Proteomes

Organism-specific databases

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00001852741-476Cys-Gly metallodipeptidase dug1

Proteomic databases

PTM databases

Interaction

Subunit

Homodimer. Component of the GSH degradosomal complex.

Protein-protein interaction databases

Structure

Family & Domains

Sequence similarities

Belongs to the peptidase M20A family.

Phylogenomic databases

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    476
  • Mass (Da)
    52,840
  • Last updated
    2012-07-11 v2
  • Checksum
    9C9FC76AAF752AEE
MKMSLDKLYEVIDKKKDEFVTRLSRAVSIPSVSADVTLRPKVVEMADFVVSEFTKLGAKMEKRDIGYHQMDGQDVPLPPIVLGQYGNDPSKKTVLIYNHFDVQPASLEDGWSTDPFTLTVDNKGRMFGRGATDDKGPLIGWISAIEAHKELGIDFPVNLLMCFEGMEEYGSEGLEDLIRAEAEKYFAKADCVCISDTYWLGTKKPVLTYGLRGVCYFNITVEGPSADLHSGVFGGTVHEPMTDLVAIMSTLVKPNGEILIPGIMDQVAELTPTEDSIYDGIDYTMEDLKEAVGADISIYPDPKRTLQHRWRYPTLSLHGIEGAFSGSGAKTVIPAKVIGKFSIRTVPNMESETVERLVKEHVTKVFNSLNSKNKLAFNNMHSGSWWISSPDHWHYDVGKKATERVYGITPDFVREGGSIPVTVTFEQSLKKNVLLLPMGRGDDGAHSINEKLDLDNFLKGIKLFCTYVHELASVSP

Sequence caution

The sequence BAA13812.1 differs from that shown. Reason: Frameshift

Features

Showing features for sequence conflict.

TypeIDPosition(s)Description
Sequence conflict439in Ref. 3; BAA13812

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
CU329671
EMBL· GenBank· DDBJ
CAB91183.2
EMBL· GenBank· DDBJ
Genomic DNA
D89150
EMBL· GenBank· DDBJ
BAA13812.1
EMBL· GenBank· DDBJ
mRNA Frameshift

Genome annotation databases

Similar Proteins

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