Q9P4U8 · AKTR2_ALTAL

Function

function

Transcription factor that regulates the expression of the gene clusters that mediate the biosynthesis of the host-selective toxins (HSTs) AK-toxins responsible for Japanese pear black spot disease by the Japanese pear pathotype (Probable). AK-toxins are esters of 9,10-epoxy 8-hydroxy 9-methyldecatrienoic acid (EDA) (PubMed:22846083).
On cellular level, AK-toxins affect plasma membrane of susceptible cells and cause a sudden increase in loss of K+ after a few minutes of toxin treatment (PubMed:22846083).

Miscellaneous

Gene clusters encoding host-selective toxins (HSTs) are localized on conditionally dispensable chromosomes (CDCs), also called supernumerary chromosomes, where they are present in multiple copies (PubMed:10975654).
The CDCs are not essential for saprophytic growth but controls host-selective pathogenicity (PubMed:10975654).

Features

Showing features for dna binding.

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TypeIDPosition(s)Description
DNA binding16-43Zn2-C6 fungal-type

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular Functionzinc ion binding

Keywords

Names & Taxonomy

Protein names

  • Recommended name
    Transcription activator AKTR-2
  • Alternative names
    • AK-toxin biosynthesis regulator 2

Gene names

    • Name
      AKTR-2

Organism names

Accessions

  • Primary accession
    Q9P4U8

Subcellular Location

Keywords

PTM/Processing

Features

Showing features for chain.

TypeIDPosition(s)Description
ChainPRO_00004448421-435Transcription activator AKTR-2

Structure

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region49-103Disordered
Compositional bias70-89Polar residues

Family and domain databases

Sequence

  • Sequence status
    Complete
  • Length
    435
  • Mass (Da)
    48,235
  • Last updated
    2000-10-01 v1
  • Checksum
    AAD028C78F51A1C9
MLQCAPKKNERLRGSCDFCTQSKLRCNKNKPSCRRCTIQQQVCVYSVARRTGRPPKHPRRADDSQETSGQHGHQDPMTSAPADSCEQQSSHLDLEGDDTDFTLVDGRTTAEGRATVAPPVLDNAFLMGETFEFNSLLDDPLVQSEDIFSFSPHIPRGEKGVHMASFHALNESTSPCSPSALLSIDVPQLPTNFRFLESFIGSELHGRNEPHPVEQPDEMEKTYDKGSILLGLDSAINAITNNGKDEPSISGWTVARPHSKHLCFCSMSMSKLQVLVSHPALCRQNSRTPFDMVLFLEEFVFGIHSDVLRCLICQSRSLHSLASLCICTDWVVEALVDVAQDLSLGQDNLGGLRAEICPPKNGSSIYVGRLILADQFRESCTRSLVKYRLRKLIPIMDTMIKLNYRGAGGALSQAIRTMVEDVRHKIESALGMMEL

Features

Showing features for compositional bias.

TypeIDPosition(s)Description
Compositional bias70-89Polar residues

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB035493
EMBL· GenBank· DDBJ
BAB07812.1
EMBL· GenBank· DDBJ
Genomic DNA

Similar Proteins

Disclaimer

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