Q9P2S2 · NRX2A_HUMAN

  • Protein
    Neurexin-2
  • Gene
    NRXN2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Neuronal cell surface protein that may be involved in cell recognition and cell adhesion. May mediate intracellular signaling.

Features

Showing features for binding site.

117122004006008001,0001,2001,4001,600
TypeIDPosition(s)Description
Binding site335Ca2+ 1 (UniProtKB | ChEBI)
Binding site352Ca2+ 1 (UniProtKB | ChEBI)
Binding site420Ca2+ 1 (UniProtKB | ChEBI)
Binding site779Ca2+ 2 (UniProtKB | ChEBI)
Binding site796Ca2+ 2 (UniProtKB | ChEBI)
Binding site854Ca2+ 2 (UniProtKB | ChEBI)
Binding site1189Ca2+ 3 (UniProtKB | ChEBI)
Binding site1206Ca2+ 3 (UniProtKB | ChEBI)
Binding site1288Ca2+ 3 (UniProtKB | ChEBI)
Binding site1290Ca2+ 3 (UniProtKB | ChEBI)

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcell projection
Cellular Componentglutamatergic synapse
Cellular Componentplasma membrane
Cellular Componentpresynaptic membrane
Cellular Componentprotein-containing complex
Molecular Functioncalcium channel regulator activity
Molecular Functioncell adhesion molecule binding
Molecular Functionmetal ion binding
Molecular Functionneuroligin family protein binding
Molecular Functiontransmembrane signaling receptor activity
Biological Processadult behavior
Biological Processchemical synaptic transmission
Biological Processgephyrin clustering involved in postsynaptic density assembly
Biological Processneuroligin clustering involved in postsynaptic membrane assembly
Biological Processneuron cell-cell adhesion
Biological Processneurotransmitter secretion
Biological Processpostsynaptic density protein 95 clustering
Biological Processpostsynaptic membrane assembly
Biological Processsignal transduction
Biological Processsocial behavior
Biological Processsynapse assembly
Biological Processvocal learning
Biological Processvocalization behavior

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neurexin-2
  • Alternative names
    • Neurexin II-alpha
    • Neurexin-2-alpha

Gene names

    • Name
      NRXN2
    • Synonyms
      KIAA0921

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9P2S2
  • Secondary accessions
    • A7E2C1
    • Q9Y2D6

Proteomes

Organism-specific databases

Subcellular Location

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-1636Extracellular
Transmembrane1637-1657Helical
Topological domain1658-1712Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_05026681in dbSNP:rs12273892

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 1,755 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, glycosylation, disulfide bond.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_000001949529-1712Neurexin-2
Glycosylation60N-linked (GlcNAc...) asparagine
Disulfide bond206↔219
Disulfide bond213↔229
Disulfide bond231↔241
Glycosylation338N-linked (GlcNAc...) asparagine
Disulfide bond450↔486
Disulfide bond657↔686
Disulfide bond694↔705
Disulfide bond699↔714
Disulfide bond716↔726
Glycosylation841N-linked (GlcNAc...) asparagine
Disulfide bond1065↔1093
Disulfide bond1100↔1111
Disulfide bond1105↔1120
Disulfide bond1122↔1132
Glycosylation1236N-linked (GlcNAc...) asparagine
Glycosylation1400O-linked (Xyl...) (heparan sulfate) serine

Post-translational modification

O-glycosylated; contains heparan sulfate. Heparan sulfate attachment is required for synapse development by mediating interactions with neuroligins.

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Predominantly expressed in brain.

Gene expression databases

Organism-specific databases

Interaction

Subunit

The laminin G-like domain 1 binds to NXPH1. Interacts with PATJ (By similarity).
Interacts with CBLN1, CBLN2 and, less avidly, with CBLN4 (By similarity).
Specific isoforms bind neuroligins NLGN1, NLGN2 and NLGN3 (By similarity).
Specific isoforms bind to alpha-dystroglycan (By similarity).
Interacts (via Laminin G-like 1 domain) with IGSF21 (Ig-like 1 domain) in a trans-interaction manner (By similarity).
Interacts with CLSTN3 (By similarity).

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region, compositional bias.

TypeIDPosition(s)Description
Domain29-206Laminin G-like 1
Domain202-242EGF-like 1
Domain289-486Laminin G-like 2
Domain493-686Laminin G-like 3
Domain690-727EGF-like 2
Domain732-904Laminin G-like 4
Domain918-1093Laminin G-like 5
Domain1096-1133EGF-like 3
Domain1137-1345Laminin G-like 6
Region1373-1392Disordered
Region1458-1489Disordered
Region1525-1626Disordered
Compositional bias1575-1601Pro residues
Region1679-1712Disordered
Compositional bias1696-1712Basic and acidic residues

Sequence similarities

Belongs to the neurexin family.

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 3 isoforms produced by Alternative promoter usage & Alternative splicing. A number of isoforms, alpha-type and beta-type are produced by alternative promoter usage. Beta-type isoforms differ from alpha-type isoforms in their N-terminus. Additional isoforms produced by alternative splicing seem to exist.

Q9P2S2-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    1,712
  • Mass (Da)
    184,982
  • Last updated
    2000-10-01 v1
  • Checksum
    E4E8EC404DA1D0B0
MASGSRWRPTPPPLLLLLLLALAARADGLEFGGGPGQWARYARWAGAASSGELSFSLRTNATRALLLYLDDGGDCDFLELLLVDGRLRLRFTLSCAEPATLQLDTPVADDRWHMVLLTRDARRTALAVDGEARAAEVRSKRREMQVASDLFVGGIPPDVRLSALTLSTVKYEPPFRGLLANLKLGERPPALLGSQGLRGATADPLCAPARNPCANGGLCTVLAPGEVGCDCSHTGFGGKFCSEEEHPMEGPAHLTLNSEVGSLLFSEGGAGRGGAGDVHQPTKGKEEFVATFKGNEFFCYDLSHNPIQSSTDEITLAFRTLQRNGLMLHTGKSADYVNLSLKSGAVWLVINLGSGAFEALVEPVNGKFNDNAWHDVRVTRNLRQHAGIGHAMVNKLHYLVTISVDGILTTTGYTQEDYTMLGSDDFFYIGGSPNTADLPGSPVSNNFMGCLKDVVYKNNDFKLELSRLAKEGDPKMKLQGDLSFRCEDVAALDPVTFESPEAFVALPRWSAKRTGSISLDFRTTEPNGLLLFSQGRRAGGGAGSHSSAQRADYFAMELLDGHLYLLLDMGSGGIKLRASSRKVNDGEWCHVDFQRDGRKGSISVNSRSTPFLATGDSEILDLESELYLGGLPEGGRVDLPLPPEVWTAALRAGYVGCVRDLFIDGRSRDLRGLAEAQGAVGVAPFCSRETLKQCASAPCRNGGVCREGWNRFICDCIGTGFLGRVCEREATVLSYDGSMYMKIMLPNAMHTEAEDVSLRFMSQRAYGLMMATTSRESADTLRLELDGGQMKLTVNLDCLRVGCAPSKGPETLFAGHKLNDNEWHTVRVVRRGKSLQLSVDNVTVEGQMAGAHMRLEFHNIETGIMTERRFISVVPSNFIGHLSGLVFNGQPYMDQCKDGDITYCELNARFGLRAIVADPVTFKSRSSYLALATLQAYASMHLFFQFKTTAPDGLLLFNSGNGNDFIVIELVKGYIHYVFDLGNGPSLMKGNSDKPVNDNQWHNVVVSRDPGNVHTLKIDSRTVTQHSNGARNLDLKGELYIGGLSKNMFSNLPKLVASRDGFQGCLASVDLNGRLPDLIADALHRIGQVERGCDGPSTTCTEESCANQGVCLQQWDGFTCDCTMTSYGGPVCNDPGTTYIFGKGGALITYTWPPNDRPSTRMDRLAVGFSTHQRSAVLVRVDSASGLGDYLQLHIDQGTVGVIFNVGTDDITIDEPNAIVSDGKYHVVRFTRSGGNATLQVDSWPVNERYPAGNFDNERLAIARQRIPYRLGRVVDEWLLDKGRQLTIFNSQAAIKIGGRDQGRPFQGQVSGLYYNGLKVLALAAESDPNVRTEGHLRLVGEGPSVLLSAETTATTLLADMATTIMETTTTMATTTTRRGRSPTLRDSTTQNTDDLLVASAECPSDDEDLEECEPSTGGELILPIITEDSLDPPPVATRSPFVPPPPTFYPFLTGVGATQDTLPPPAARRPPSGGPCQAERDDSDCEEPIEASGFASGEVFDSSLPPTDDEDFYTTFPLVTDRTTLLSPRKPAPRPNLRTDGATGAPGVLFAPSAPAPNLPAGKMNHRDPLQPLLENPPLGPGAPTSFEPRRPPPLRPGVTSAPGFPHLPTANPTGPGERGPPGAVEVIRESSSTTGMVVGIVAAAALCILILLYAMYKYRNRDEGSYQVDQSRNYISNSAQSNGAVVKEKAPAAPKTPSKAKKNKDKEYYV

Q9P2S2-2

P58401-1

The sequence of this isoform can be found in the external entry linked below. Isoforms of the same protein are often annotated in two different entries if their sequences differ significantly.

View isoform

Computationally mapped potential isoform sequences

There are 13 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8I5QJ84A0A8I5QJ84_HUMANNRXN21200
A0A8I5QJA1A0A8I5QJA1_HUMANNRXN299
A0A8I5QKZ8A0A8I5QKZ8_HUMANNRXN21230
P58401NRX2B_HUMANNRXN2666
H7BZC7H7BZC7_HUMANNRXN2292
H7C3D6H7C3D6_HUMANNRXN2445
H7C3J4H7C3J4_HUMANNRXN2415
H7C2R8H7C2R8_HUMANNRXN2341
G5E9G7G5E9G7_HUMANNRXN21705
A0A8I5KTJ4A0A8I5KTJ4_HUMANNRXN2780
A0A8I5KY42A0A8I5KY42_HUMANNRXN21511
A0A994J5C3A0A994J5C3_HUMANNRXN21715
A0A994J4N8A0A994J4N8_HUMANNRXN21521

Sequence caution

The sequence BAA76765.2 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_003505260-283in isoform 2a
Alternative sequenceVSP_003506393-399in isoform 2a
Alternative sequenceVSP_003507797-806in isoform 2a
Alternative sequenceVSP_0035081253-1282in isoform 2a
Compositional bias1575-1601Pro residues
Compositional bias1696-1712Basic and acidic residues

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB035266
EMBL· GenBank· DDBJ
BAA94075.1
EMBL· GenBank· DDBJ
mRNA
AB023138
EMBL· GenBank· DDBJ
BAA76765.2
EMBL· GenBank· DDBJ
mRNA Different initiation
AC044790
EMBL· GenBank· DDBJ
AAK68154.1
EMBL· GenBank· DDBJ
Genomic DNA
BC150275
EMBL· GenBank· DDBJ
AAI50276.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
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