Q9P287 · BCCIP_HUMAN

  • Protein
    BRCA2 and CDKN1A-interacting protein
  • Gene
    BCCIP
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

During interphase, required for microtubule organizing and anchoring activities. During mitosis, required for the organization and stabilization of the spindle pole (PubMed:28394342).
Isoform 2/alpha is particularly important for the regulation of microtubule anchoring, microtubule stability, spindle architecture and spindle orientation, compared to isoform 1/beta (PubMed:28394342).
May promote cell cycle arrest by enhancing the inhibition of CDK2 activity by CDKN1A. May be required for repair of DNA damage by homologous recombination in conjunction with BRCA2. May not be involved in non-homologous end joining (NHEJ)

Miscellaneous

HT1080 cells that constitutively express low levels of BCCIP display increased levels of spontaneous single-stranded DNA and double-strand breaks.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentcentriole
Cellular Componentcentrosome
Cellular Componentcytosol
Cellular Componentmitotic spindle pole
Cellular Componentnuclear cyclin-dependent protein kinase holoenzyme complex
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular Functionkinase regulator activity
Molecular FunctionRNA binding
Molecular Functiontubulin binding
Biological ProcessDNA repair
Biological Processestablishment of mitotic spindle orientation
Biological Processmicrotubule anchoring
Biological Processmicrotubule cytoskeleton organization
Biological Processmitotic spindle assembly
Biological Processmitotic spindle organization
Biological Processneuroendocrine cell differentiation
Biological Processregulation of cyclin-dependent protein serine/threonine kinase activity

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    BRCA2 and CDKN1A-interacting protein
  • Alternative names
    • P21- and CDK-associated protein 1
    • Protein TOK-1

Gene names

    • Name
      BCCIP
    • Synonyms
      TOK1

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9P287
  • Secondary accessions
    • B3KP45
    • Q8ND15
    • Q96GC4
    • Q9P288

Proteomes

Organism-specific databases

Subcellular Location

Nucleus
Note: Colocalizes with BRCA2 in discrete nuclear foci (PubMed:15713648).
In interphase, preferential localizes to the mother centriole (PubMed:28394342).
Recruited to the spindle pole matrix and centrosome by microtubules and dynein/dynactin activity (PubMed:28394342).

Isoform 1

Note: Isoform 1/beta tends to be less abundant at, and less strongly associated with, centrosomes than isoform 2/alpha.

Isoform 2

Note: Isoform 2/alpha tends to be more abundant at, and more strongly associated with, centrosomes than isoform 1/beta.

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_046642254in dbSNP:rs17153610

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 380 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002496871-314UniProtBRCA2 and CDKN1A-interacting protein
Modified residue42UniProtPhosphoserine
Modified residue (large scale data)42PRIDEPhosphoserine
Modified residue112UniProtPhosphoserine
Modified residue (large scale data)112PRIDEPhosphoserine
Modified residue (large scale data)115PRIDEPhosphoserine
Modified residue (large scale data)234PRIDEPhosphoserine
Modified residue281UniProtPhosphoserine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed at high levels in testis and skeletal muscle and at lower levels in brain, heart, kidney, liver, lung, ovary, pancreas, placenta, and spleen.

Developmental stage

Isoform 1 is expressed throughout the cell cycle. Isoform 2 is expressed following mitosis and peaks in the G1/S phase of the cell cycle.

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with BRCA2, CDKN1A and MTDH/LYRIC (PubMed:10878006, PubMed:11313963, PubMed:14726710, PubMed:15713648, PubMed:18440304).
Isoform 2/alpha, but not isoform 1/beta, interacts with DCTN1/p150-glued and ACTR1A/ARP1 (PubMed:28394342).
Both isoform 1 and isoform 2 interact with alpha-, beta- and gamma-tubulins (PubMed:28394342).
Interacts with TENT5C; the interaction has no effect on TENT5C poly(A) polymerase function (PubMed:28931820).

Binary interactions

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region1-56Disordered
Compositional bias28-56Acidic residues
Region59-167Interaction with BRCA2
Region161-259Interaction with CDKN1A

Sequence similarities

Belongs to the BCP1 family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete

This entry describes 4 isoforms produced by Alternative splicing.

Q9P287-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    Beta
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    314
  • Mass (Da)
    35,979
  • Last updated
    2000-10-01 v1
  • Checksum
    203CA32F7BE0A806
MASRSKRRAVESGVPQPPDPPVQRDEEEEKEVENEDEDDDDSDKEKDEEDEVIDEEVNIEFEAYSLSDNDYDGIKKLLQQLFLKAPVNTAELTDLLIQQNHIGSVIKQTDVSEDSNDDMDEDEVFGFISLLNLTERKGTQCVEQIQELVLRFCEKNCEKSMVEQLDKFLNDTTKPVGLLLSERFINVPPQIALPMYQQLQKELAGAHRTNKPCGKCYFYLLISKTFVEAGKNNSKKKPSNKKKAALMFANAEEEFFYEKAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV

Q9P287-2

  • Name
    2
  • Synonyms
    Alpha
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 259-314: KAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV → EQGKPEVLGGPDTRRGLEPVPIQHNGGSRGQVTALVSLKAGLIQSRSTLSDFQGTFMTVGIALS

Q9P287-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 285-314: VPMTPLRTVMLIPGDKMNEIMDKLKEYLSV → WSVPPVLE

Q9P287-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 259-314: KAILKFNYSVQEESDTCLGGKWSFDDVPMTPLRTVMLIPGDKMNEIMDKLKEYLSV → EQGKPEVLGGPDTRRGLEPVPIQHNGWSVPPVLE

Features

Showing features for compositional bias, sequence conflict, alternative sequence.

TypeIDPosition(s)Description
Compositional bias28-56Acidic residues
Sequence conflict75in Ref. 3; BAG51557
Sequence conflict230in Ref. 6; AAH09771
Alternative sequenceVSP_020540259-314in isoform 2
Alternative sequenceVSP_042023259-314in isoform 4
Alternative sequenceVSP_020541285-314in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB040450
EMBL· GenBank· DDBJ
BAA92927.1
EMBL· GenBank· DDBJ
mRNA
AB040451
EMBL· GenBank· DDBJ
BAA92928.1
EMBL· GenBank· DDBJ
mRNA
AY064247
EMBL· GenBank· DDBJ
AAL55436.1
EMBL· GenBank· DDBJ
Genomic DNA
AY064247
EMBL· GenBank· DDBJ
AAL55438.1
EMBL· GenBank· DDBJ
Genomic DNA
AY064248
EMBL· GenBank· DDBJ
AAL55439.1
EMBL· GenBank· DDBJ
mRNA
AY064249
EMBL· GenBank· DDBJ
AAL55440.1
EMBL· GenBank· DDBJ
mRNA
AK055691
EMBL· GenBank· DDBJ
BAG51557.1
EMBL· GenBank· DDBJ
mRNA
AL834458
EMBL· GenBank· DDBJ
CAD39118.1
EMBL· GenBank· DDBJ
mRNA
AL360176
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC009771
EMBL· GenBank· DDBJ
AAH09771.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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