Q9P242 · NYAP2_HUMAN

  • Protein
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
  • Gene
    NYAP2
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    4/5

Function

function

Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Biological Processneuron projection morphogenesis
Biological Processphosphatidylinositol 3-kinase/protein kinase B signal transduction

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2

Gene names

    • Name
      NYAP2
    • Synonyms
      KIAA1486

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9P242
  • Secondary accessions
    • A2RRN4
    • Q96NL2

Proteomes

Organism-specific databases

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_039933205in dbSNP:rs7422680
Natural variantVAR_039934586in dbSNP:rs3748993

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 2 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00003258301-653UniProtNeuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 2
Modified residue81UniProtOmega-N-methylarginine
Modified residue120UniProtPhosphoserine
Modified residue (large scale data)154PRIDEPhosphoserine
Modified residue (large scale data)169PRIDEPhosphothreonine
Modified residue (large scale data)183PRIDEPhosphoserine
Modified residue206UniProtPhosphoserine
Modified residue (large scale data)206PRIDEPhosphoserine
Modified residue (large scale data)245PRIDEPhosphotyrosine
Modified residue268UniProtPhosphotyrosine
Modified residue (large scale data)379PRIDEPhosphoserine
Modified residue (large scale data)413PRIDEPhosphoserine
Modified residue434UniProtPhosphoserine
Modified residue (large scale data)434PRIDEPhosphoserine
Modified residue (large scale data)436PRIDEPhosphoserine
Modified residue (large scale data)438PRIDEPhosphoserine
Modified residue (large scale data)447PRIDEPhosphothreonine
Modified residue (large scale data)462PRIDEPhosphoserine
Modified residue (large scale data)464PRIDEPhosphoserine
Modified residue (large scale data)469PRIDEPhosphoserine
Modified residue (large scale data)476PRIDEPhosphothreonine
Modified residue (large scale data)504PRIDEPhosphoserine
Modified residue (large scale data)506PRIDEPhosphothreonine
Modified residue (large scale data)508PRIDEPhosphothreonine
Modified residue (large scale data)509PRIDEPhosphoserine
Modified residue (large scale data)551PRIDEPhosphoserine
Modified residue (large scale data)597PRIDEPhosphoserine
Modified residue (large scale data)599PRIDEPhosphoserine

Post-translational modification

Phosphorylated on tyrosine residues by FYN upon stimulation with CNTN5.

Keywords

Proteomic databases

PTM databases

Expression

Gene expression databases

Organism-specific databases

Interaction

Subunit

Interacts with ACOT9, ARHGAP26 and PIK3R2. Interacts with components of the WAVE1 complex, CYFIP1 and NCKAP1; this interaction mediates PI3K-WAVE1 association and actin cytoskeleton remodeling (By similarity).

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9P242AGFG1 P525943EBI-10269689, EBI-996560
BINARY Q9P242MORN4 Q8NDC44EBI-10269689, EBI-10269566

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for region, compositional bias.

TypeIDPosition(s)Description
Region99-243Disordered
Compositional bias112-134Polar residues
Compositional bias147-170Polar residues
Region150-161Involved in CYFIP1- and NCKAP1-binding
Compositional bias171-192Basic and acidic residues
Region373-653Disordered
Compositional bias422-445Polar residues
Compositional bias462-478Polar residues
Compositional bias499-527Polar residues
Compositional bias529-572Basic and acidic residues
Compositional bias590-653Polar residues

Sequence similarities

Belongs to the NYAP family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9P242-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    653
  • Mass (Da)
    70,548
  • Last updated
    2010-05-18 v3
  • Checksum
    78451871EC7822C6
MISSKMMSSNPEEDPLDTFLQYIEDMGMKAYDGLVIQNASDIARENDRLRNETNLAYLKEKNEKRRRQEEAIKRIGGEVGRGHEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFSVRSQSLHSVGGTDDDSSCGSRRQPPPKPKRDPSTKLSTSSETVSSTAASKSGKTPERTEASAKPRPHSDEYSKKIPPPKPKRNPNTQLSTSFDETYIKKHGPRRTSLPRDSSLSQMGSPAGDPEEEEPVYIEMVGNILRDFRKEDDDQSEAVYEEMKYPIFDDLGQDAKCDFDHHSCSSQCATPTVPDLDFAKASVPCPPKGLLCDIPPPFPNLLSHRPPLLVFPPAPVHCSPNSDESPLTPLEVTKLPVLENVSYMKQPAGASPSTLPSHVPGHAKLEKEQAAALGPASATPALSSSPPPPSTLYRTQSPHGYPKSHSTSPSPVSMGRSLTPLSLKRPPPYDAVHSGSLSRSSPSVPHSTPRPVSQDGAKMVNAAVNTYGAAPGGSRSRTPTSPLEELTSLFSSGRSLLRKSSSGRRSKEPAEKSTEELKVRSHSTEPLPKLDNKERGHHGASSSREPVKAQEWDGTPGTPVVTSRLGRCSVSPTLLAGNHSSEPKVSCKLGRSASTSGVPPPSVTPLRQSSDLQQSQVPSSLANRD

Q9P242-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 76-145: GGEVGRGHEGSYVGKHFRMGFMTMPAPQDRLPHPCSSGFSVRSQSLHSVGGTDDDSSCGSRRQPPPKPKR → NRGTESPKPQHGAITKVGQQGKRPPWGVFLQRACQSSGMGWNTRATCGHQSTRKMLCEPHLVSGKPQFRA
    • 146-653: Missing

Q9P242-3

Computationally mapped potential isoform sequences

There are 2 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
A0A8V8N5G5A0A8V8N5G5_HUMANNYAP2719
A0A8Q3SIC2A0A8Q3SIC2_HUMANNYAP2149

Sequence caution

The sequence BAA96010.1 differs from that shown. Reason: Erroneous initiation Extended N-terminus.

Features

Showing features for alternative sequence, compositional bias.

TypeIDPosition(s)Description
Alternative sequenceVSP_0324311-486in isoform 3
Alternative sequenceVSP_03243276-145in isoform 2
Compositional bias112-134Polar residues
Alternative sequenceVSP_032433146-653in isoform 2
Compositional bias147-170Polar residues
Compositional bias171-192Basic and acidic residues
Compositional bias422-445Polar residues
Compositional bias462-478Polar residues
Compositional bias499-527Polar residues
Compositional bias529-572Basic and acidic residues
Compositional bias590-653Polar residues
Alternative sequenceVSP_032434645in isoform 3
Alternative sequenceVSP_032435646-653in isoform 3

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB040919
EMBL· GenBank· DDBJ
BAA96010.1
EMBL· GenBank· DDBJ
mRNA Different initiation
AK055226
EMBL· GenBank· DDBJ
BAB70880.1
EMBL· GenBank· DDBJ
mRNA
AC016717
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC019231
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC067961
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AC106890
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
BC131727
EMBL· GenBank· DDBJ
AAI31728.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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