Q9P1Z2 · CACO1_HUMAN
- ProteinCalcium-binding and coiled-coil domain-containing protein 1
- GeneCALCOCO1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids691 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
In association with CCAR1 enhances GATA1- and MED1-mediated transcriptional activation from the gamma-globin promoter during erythroid differentiation of K562 erythroleukemia cells (PubMed:24245781).
Features
Showing features for binding site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | chromatin | |
Cellular Component | cytosol | |
Cellular Component | intracellular membrane-bounded organelle | |
Cellular Component | nucleus | |
Molecular Function | beta-catenin binding | |
Molecular Function | chromatin binding | |
Molecular Function | metal ion binding | |
Molecular Function | nuclear receptor coactivator activity | |
Molecular Function | RNA polymerase II cis-regulatory region sequence-specific DNA binding | |
Molecular Function | sequence-specific DNA binding | |
Molecular Function | transcription cis-regulatory region binding | |
Molecular Function | transcription coactivator activity | |
Molecular Function | transcription coregulator activity | |
Biological Process | nuclear receptor-mediated steroid hormone signaling pathway | |
Biological Process | positive regulation of DNA-templated transcription | |
Biological Process | positive regulation of gene expression | |
Biological Process | positive regulation of transcription by RNA polymerase II | |
Biological Process | signal transduction | |
Biological Process | Wnt signaling pathway |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
The subsequence SGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE, which contains the Zn-C2H2_12 domain, shows transcriptional activator activity in a high-throughput recruitment assay.
Names & Taxonomy
Protein names
- Recommended nameCalcium-binding and coiled-coil domain-containing protein 1
- Alternative names
Gene names
- Community suggested namesCALCOCO1
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9P1Z2
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_036881 | 393 | in dbSNP:rs3741659 | |||
Sequence: R → K |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 691 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue, modified residue (large scale data).
Type | ID | Position(s) | Source | Description | |||
---|---|---|---|---|---|---|---|
Chain | PRO_0000308899 | 1-691 | UniProt | Calcium-binding and coiled-coil domain-containing protein 1 | |||
Sequence: MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGISRSHGEITEERDILSRQQGDHVARILELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELEPLKEQLRGAQELAASSQQKATLLGEELASAAAARDRTIAELHRSRLEVAEVNGRLAELGLHLKEEKCQWSKERAGLLQSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE | |||||||
Modified residue | 4 | UniProt | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 11 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 562 | PRIDE | Phosphoserine | ||||
Sequence: S | |||||||
Modified residue (large scale data) | 563 | PRIDE | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Subunit
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9P1Z2 | BFSP2 Q13515 | 4 | EBI-749920, EBI-10229433 | |
BINARY | Q9P1Z2 | CEP19 Q96LK0 | 6 | EBI-749920, EBI-741885 | |
BINARY | Q9P1Z2 | CWF19L2 Q2TBE0 | 6 | EBI-749920, EBI-5453285 | |
BINARY | Q9P1Z2 | DUSP13B Q9UII6 | 6 | EBI-749920, EBI-749800 | |
BINARY | Q9P1Z2 | ENKD1 Q9H0I2 | 3 | EBI-749920, EBI-744099 | |
BINARY | Q9P1Z2 | FAM161A Q3B820 | 3 | EBI-749920, EBI-719941 | |
BINARY | Q9P1Z2 | GABARAPL1 Q9H0R8 | 3 | EBI-749920, EBI-746969 | |
BINARY | Q9P1Z2 | GABARAPL2 P60520 | 3 | EBI-749920, EBI-720116 | |
BINARY | Q9P1Z2 | ISOC1 Q96CN7 | 3 | EBI-749920, EBI-2805787 | |
BINARY | Q9P1Z2 | NDC80 O14777 | 5 | EBI-749920, EBI-715849 | |
BINARY | Q9P1Z2 | PRKAA2 P54646 | 3 | EBI-749920, EBI-1383852 | |
BINARY | Q9P1Z2 | RNF8 O76064 | 3 | EBI-749920, EBI-373337 | |
BINARY | Q9P1Z2 | TBC1D15 Q8TC07 | 3 | EBI-749920, EBI-1048247 | |
BINARY | Q9P1Z2 | ZMAT2 Q96NC0 | 3 | EBI-749920, EBI-2682299 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, coiled coil, zinc finger.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-30 | p300 KIX-binding | ||||
Sequence: MEESPLSRAPSRGGVNFLNVARTYIPNTKV | ||||||
Region | 1-190 | N-terminal AD (CTNNB1 binding site) | ||||
Sequence: MEESPLSRAPSRGGVNFLNVARTYIPNTKVECHYTLPPGTMPSASDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMDELVTLEEADGGSDILLVVPKATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALAT | ||||||
Region | 45-125 | Interaction with GATA1 | ||||
Sequence: SDWIGIFKVEAACVRDYHTFVWSSVPESTTDGSPIHTSVQFQASYLPKPGAQLYQFRYVNRQGQVCGQSPPFQFREPRPMD | ||||||
Coiled coil | 145-205 | |||||
Sequence: KATVLQNQLDESQQERNDLMQLKLQLEGQVTELRSRVQELERALATARQEHTELMEQYKGI | ||||||
Coiled coil | 232-339 | |||||
Sequence: ELEDDIQTISEKVLTKEVELDRLRDTVKALTREQEKLLGQLKEVQADKEQSEAELQVAQQENHHLNLDLKEAKSWQEEQSAQAQRLKDKVAQMKDTLGQAQQRVAELE | ||||||
Coiled coil | 417-514 | |||||
Sequence: QSVEAEKDKILKLSAEILRLEKAVQEERTQNQVFKTELAREKDSSLVQLSESKRELTELRSALRVLQKEKEQLQEEKQELLEYMRKLEARLEKVADEK | ||||||
Region | 501-691 | C-terminal AD (CTNNB1 binding site); interaction with CCAR1 | ||||
Sequence: RKLEARLEKVADEKWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLMAAVQSGGEEANLLLPELGSAFYDMASGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE | ||||||
Region | 514-607 | Disordered | ||||
Sequence: KWNEDATTEDEEAAVGLSCPAALTDSEDESPEDMRLPPYGLCERGDPGSSPAGPREASPLVVISQPAPISPHLSGPAEDSSSDSEAEDEKSVLM | ||||||
Zinc finger | 653-679 | UBZ1-type | ||||
Sequence: WKECPICKERFPAESDKDALEDHMDGH |
Domain
Sequence similarities
Keywords
- Domain
Phylogenomic databases
Family and domain databases
Sequence & Isoforms
- Sequence statusComplete
This entry describes 4 isoforms produced by Alternative splicing.
Q9P1Z2-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length691
- Mass (Da)77,336
- Last updated2007-10-23 v2
- Checksum06A4C6BAB896759F
Q9P1Z2-2
- Name2
- Differences from canonical
- 633-691: SGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE → R
Q9P1Z2-3
- Name3
- Differences from canonical
- 598-598: Missing
Q9P1Z2-4
- Name4
Computationally mapped potential isoform sequences
There are 9 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for alternative sequence, sequence conflict.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_041471 | 87-119 | in isoform 4 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_041472 | 287-338 | in isoform 4 | |||
Sequence: Missing | ||||||
Sequence conflict | 381 | in Ref. 5; BAG53720 | ||||
Sequence: H → R | ||||||
Sequence conflict | 486 | in Ref. 7; CAG38598 | ||||
Sequence: K → R | ||||||
Alternative sequence | VSP_029052 | 598 | in isoform 3 | |||
Sequence: Missing | ||||||
Alternative sequence | VSP_029053 | 633-691 | in isoform 2 | |||
Sequence: SGFTVGTLSETSTGGPATPTWKECPICKERFPAESDKDALEDHMDGHFFFSTQDPFTFE → R | ||||||
Sequence conflict | 660 | in Ref. 7; CAG38598 | ||||
Sequence: K → E |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AY563137 EMBL· GenBank· DDBJ | AAT68474.1 EMBL· GenBank· DDBJ | mRNA | ||
AB040969 EMBL· GenBank· DDBJ | BAA96060.1 EMBL· GenBank· DDBJ | mRNA | Different initiation | |
AL136895 EMBL· GenBank· DDBJ | CAB66829.1 EMBL· GenBank· DDBJ | mRNA | ||
AY358397 EMBL· GenBank· DDBJ | AAQ88763.1 EMBL· GenBank· DDBJ | mRNA | ||
AK122773 EMBL· GenBank· DDBJ | BAG53720.1 EMBL· GenBank· DDBJ | mRNA | ||
AK027881 EMBL· GenBank· DDBJ | BAB55428.1 EMBL· GenBank· DDBJ | mRNA | ||
AF370415 EMBL· GenBank· DDBJ | AAQ15251.1 EMBL· GenBank· DDBJ | mRNA | ||
CR533567 EMBL· GenBank· DDBJ | CAG38598.1 EMBL· GenBank· DDBJ | mRNA | ||
CH471054 EMBL· GenBank· DDBJ | EAW96728.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC003177 EMBL· GenBank· DDBJ | AAH03177.1 EMBL· GenBank· DDBJ | mRNA | ||
AY211909 EMBL· GenBank· DDBJ | AAO65163.1 EMBL· GenBank· DDBJ | mRNA |