Q9P1W8 · SIRPG_HUMAN

  • Protein
    Signal-regulatory protein gamma
  • Gene
    SIRPG
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Probable immunoglobulin-like cell surface receptor. On binding with CD47, mediates cell-cell adhesion. Engagement on T-cells by CD47 on antigen-presenting cells results in enhanced antigen-specific T-cell proliferation and costimulates T-cell activation.

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentmembrane
Cellular Componentplasma membrane
Biological Processcell adhesion
Biological Processcell-cell signaling
Biological Processintracellular signal transduction
Biological Processnegative regulation of cell population proliferation
Biological Processpositive regulation of cell population proliferation
Biological Processpositive regulation of cell-cell adhesion
Biological Processpositive regulation of phagocytosis
Biological Processpositive regulation of T cell activation

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    Signal-regulatory protein gamma
  • Short names
    SIRP-gamma
  • Alternative names
    • CD172 antigen-like family member B
    • Signal-regulatory protein beta-2 (SIRP-b2; SIRP-beta-2)
  • CD Antigen Name
    • CD172g

Gene names

    • Name
      SIRPG
    • Synonyms
      SIRPB2

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9P1W8
  • Secondary accessions
    • B1AKP6
    • Q5D051
    • Q5JV25
    • Q5MKL4
    • Q8WWA5
    • Q9NQK8

Proteomes

Organism-specific databases

Subcellular Location

Membrane
; Single-pass type I membrane protein

Features

Showing features for topological domain, transmembrane.

TypeIDPosition(s)Description
Topological domain29-360Extracellular
Transmembrane361-383Helical
Topological domain384-387Cytoplasmic

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_049936263in dbSNP:rs6043409
Natural variantVAR_049937286in dbSNP:rs6034239

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 558 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for signal, chain, disulfide bond, glycosylation.

TypeIDPosition(s)Description
Signal1-28
ChainPRO_000001495729-387Signal-regulatory protein gamma
Disulfide bond53↔119
Disulfide bond168↔226
Glycosylation243N-linked (GlcNAc...) asparagine
Glycosylation268N-linked (GlcNAc...) asparagine
Disulfide bond271↔329
Glycosylation309N-linked (GlcNAc...) asparagine
Glycosylation317N-linked (GlcNAc...) asparagine

Keywords

Proteomic databases

PTM databases

Expression

Tissue specificity

Detected in liver, and at very low levels in brain, heart, lung, pancreas, kidney, placenta and skeletal muscle. Expressed on CD4+ T-cells, CD8+ T-cells, CD56-bright natural killer (NK) cells, CD20+ cells, and all activated NK cells. Mainly present in the paracortical T-cell area of lymph nodes, with only sparse positive cells in the mantle and in the germinal center of B-cell follicles. In the thymus, primarily expressed in the medulla on mature T-lymphocytes that have undergone thymic selection.

Gene expression databases

    • ENSG00000089012Expressed in male germ line stem cell (sensu Vertebrata) in testis and 111 other cell types or tissues

Organism-specific databases

Interaction

Subunit

Interacts with CD47.

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9P1W8CD47 Q087222EBI-1268284, EBI-1268321
BINARY Q9P1W8FOS P011003EBI-1268284, EBI-852851
BINARY Q9P1W8GATM P504403EBI-1268284, EBI-2552594

Protein-protein interaction databases

Miscellaneous

Family & Domains

Features

Showing features for domain.

TypeIDPosition(s)Description
Domain29-137Ig-like V-type
Domain146-245Ig-like C1-type 1
Domain252-340Ig-like C1-type 2

Keywords

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (4)
  • Sequence status
    Complete
  • Sequence processing
    The displayed sequence is further processed into a mature form.

This entry describes 4 isoforms produced by Alternative splicing.

Q9P1W8-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Length
    387
  • Mass (Da)
    42,498
  • Last updated
    2007-01-23 v3
  • Checksum
    0F5099BE1DE35AC8
MPVPASWPHPPGPFLLLTLLLGLTEVAGEEELQMIQPEKLLLVTVGKTATLHCTVTSLLPVGPVLWFRGVGPGRELIYNQKEGHFPRVTTVSDLTKRNNMDFSIRISSITPADVGTYYCVKFRKGSPENVEFKSGPGTEMALGAKPSAPVVLGPAARTTPEHTVSFTCESHGFSPRDITLKWFKNGNELSDFQTNVDPTGQSVAYSIRSTARVVLDPWDVRSQVICEVAHVTLQGDPLRGTANLSEAIRVPPTLEVTQQPMRVGNQVNVTCQVRKFYPQSLQLTWSENGNVCQRETASTLTENKDGTYNWTSWFLVNISDQRDDVVLTCQVKHDGQLAVSKRLALEVTVHQKDQSSDATPGPASSLTALLLIAVLLGPIYVPWKQKT

Q9P1W8-2

  • Name
    2
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9P1W8-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9P1W8-4

  • Name
    4
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Features

Showing features for alternative sequence.

TypeIDPosition(s)Description
Alternative sequenceVSP_0070271-33in isoform 2
Alternative sequenceVSP_007028144-360in isoform 3
Alternative sequenceVSP_026960250-360in isoform 4

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AB042624
EMBL· GenBank· DDBJ
BAA95692.1
EMBL· GenBank· DDBJ
mRNA
AY748247
EMBL· GenBank· DDBJ
AAV88530.1
EMBL· GenBank· DDBJ
mRNA
AY748248
EMBL· GenBank· DDBJ
AAV88531.1
EMBL· GenBank· DDBJ
mRNA
AL109809
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL138804
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
CH471133
EMBL· GenBank· DDBJ
EAX10616.1
EMBL· GenBank· DDBJ
Genomic DNA
BC020629
EMBL· GenBank· DDBJ
AAH20629.2
EMBL· GenBank· DDBJ
mRNA
BC064532
EMBL· GenBank· DDBJ
AAH64532.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

Any medical or genetic information present in this entry is provided for research, educational and informational purposes only. It is not in any way intended to be used as a substitute for professional medical advice, diagnosis, treatment or care. Our staff consists of biologists and biochemists that are not trained to give medical advice.
We'd like to inform you that we have updated our Privacy Notice to comply with Europe’s new General Data Protection Regulation (GDPR) that applies since 25 May 2018.
FeedbackHelp