Q9P127 · LUZP4_HUMAN
- ProteinLeucine zipper protein 4
- GeneLUZP4
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids313 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Export adapter involved in mRNA nuclear export in cancer cells. Binds and enhances the RNA-binding activity of the nuclear RNA export factor NXF1. Can restore mRNA export function in cells compromised by loss of mRNA export adapters (PubMed:25662211).
GO annotations
all annotations | all molecular function | virus receptor activity | dna binding | rna binding | cytoskeletal motor activity | catalytic activity | gtpase activity | structural molecule activity | transporter activity | cytoskeletal protein binding | lipid binding | cyclase activity | antioxidant activity | oxidoreductase activity | transferase activity | hydrolase activity | lyase activity | isomerase activity | ligase activity | protein tag activity | cargo receptor activity | histone binding | protein folding chaperone | translation regulator activity | nutrient reservoir activity | receptor ligand activity | molecular transducer activity | molecular adaptor activity | toxin activity | cell adhesion mediator activity | molecular function regulator activity | virus coreceptor activity | catalytic activity, acting on a protein | catalytic activity, acting on dna | catalytic activity, acting on rna | molecular carrier activity | transcription regulator activity | general transcription initiation factor activity | molecular sensor activity | molecular sequestering activity | atp-dependent activity | other molecular function | all biological process | mitotic cell cycle | cytokinesis | cytoplasmic translation | immune system process | muscle system process | circulatory system process | renal system process | respiratory system process | carbohydrate metabolic process | generation of precursor metabolites and energy | dna replication | dna repair | dna recombination | chromatin organization | dna-templated transcription | regulation of dna-templated transcription | trna metabolic process | protein folding | protein glycosylation | amino acid metabolic process | modified amino acid metabolic process | lipid metabolic process | vitamin metabolic process | sulfur compound metabolic process | intracellular protein transport | nucleocytoplasmic transport | autophagy | inflammatory response | mitochondrion organization | cytoskeleton organization | microtubule-based movement | peroxisome organization | lysosome organization | chromosome segregation | cell adhesion | establishment or maintenance of cell polarity | programmed cell death | photosynthesis | mrna metabolic process | snrna metabolic process | vesicle-mediated transport | reproductive process | digestive system process | signaling | cell differentiation | protein catabolic process | extracellular matrix organization | regulatory ncrna-mediated gene silencing | telomere organization | cell junction organization | wound healing | ribosome biogenesis | cilium organization | anatomical structure development | cell motility | nervous system process | endocrine process | protein maturation | transmembrane transport | nucleobase-containing small molecule metabolic process | hepaticobiliary system process | membrane organization | protein-containing complex assembly | cell wall organization or biogenesis | nitrogen cycle metabolic process | protein localization to plasma membrane | defense response to other organism | detoxification | meiotic nuclear division | mitotic nuclear division | mitochondrial gene expression | carbohydrate derivative metabolic process | other biological process | all cellular component | nuclear chromosome | extracellular region | extracellular space | cell wall | nucleus | nuclear envelope | nucleoplasm | chromosome | nucleolus | mitochondrion | lysosome | endosome | vacuole | peroxisome | endoplasmic reticulum | golgi apparatus | lipid droplet | microtubule organizing center | cytosol | ribosome | cytoskeleton | plasma membrane | cilium | plastid | thylakoid | external encapsulating structure | extracellular matrix | cytoplasmic vesicle | organelle | other cellular component | |||
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
Aspect | Term | |
---|---|---|
Cellular Component | cytoplasm | |
Cellular Component | nucleus | |
Molecular Function | RNA binding | |
Biological Process | mRNA transport |
Keywords
- Molecular function
- Biological process
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameLeucine zipper protein 4
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9P127
- Secondary accessions
Proteomes
Organism-specific databases
Disease & Variants
Features
Showing features for natural variant.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Natural variant | VAR_051146 | 14 | in dbSNP:rs10482480 | |||
Sequence: P → S | ||||||
Natural variant | VAR_051147 | 306 | in dbSNP:rs35314601 | |||
Sequence: T → A |
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 351 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Genetic variation databases
PTM/Processing
Features
Showing features for chain, modified residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000288649 | 1-313 | Leucine zipper protein 4 | |||
Sequence: MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDDIIIYKELEGTNAEEEKNKRQNHSKKESPSRQQSKAHRHRHRRGYSRCRSNSEEGNHDKKPSQKPSGFKSGQHPLNGQPLIEQEKCSDNYEAQAEKNQGQSEGNQHQSEGNPDKSEESQGQPEENHHSERSRNHLERSLSQSDRSQGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQGDLVDTQSDLIATQRDLIATQKDLIATQRDLIATQRDLIVTQRDLVATERDLINQSGRSHGQSERHQRYSTGKNTITT | ||||||
Modified residue | 234 | Phosphoserine | ||||
Sequence: S |
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Tissue specificity
Expressed specifically in testis. Also expressed in a wide variety of cancer types, but particularly high levels of expression observed in melanoma cells.
Gene expression databases
Organism-specific databases
Interaction
Subunit
Interacts with NXF1, NXF2, THOC1, THOC5, DDX39B/UAP56 and SRRT.
Binary interactions
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for region, motif, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Region | 1-119 | Interaction with DDX39B/UAP56 | ||||
Sequence: MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDDIIIYKELEGTNAEEEKNKRQNHSKKESPSRQQSKAHRHRHRRGYSRCRSNSEEGNHDKKPSQKPSGFKSGQHPLNGQPLIEQEKCSD | ||||||
Region | 1-238 | Disordered | ||||
Sequence: MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDDIIIYKELEGTNAEEEKNKRQNHSKKESPSRQQSKAHRHRHRRGYSRCRSNSEEGNHDKKPSQKPSGFKSGQHPLNGQPLIEQEKCSDNYEAQAEKNQGQSEGNQHQSEGNPDKSEESQGQPEENHHSERSRNHLERSLSQSDRSQGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQGDL | ||||||
Motif | 22-40 | UAP56-binding motif (UBM); required for proper nuclear localization | ||||
Sequence: KVNFLDMSLDDIIIYKELE | ||||||
Compositional bias | 38-62 | Basic and acidic residues | ||||
Sequence: ELEGTNAEEEKNKRQNHSKKESPSR | ||||||
Region | 51-80 | Arg-rich; required for RNA-binding | ||||
Sequence: RQNHSKKESPSRQQSKAHRHRHRRGYSRCR | ||||||
Compositional bias | 63-77 | Basic residues | ||||
Sequence: QQSKAHRHRHRRGYS | ||||||
Compositional bias | 78-95 | Basic and acidic residues | ||||
Sequence: RCRSNSEEGNHDKKPSQK | ||||||
Compositional bias | 123-139 | Polar residues | ||||
Sequence: AQAEKNQGQSEGNQHQS | ||||||
Compositional bias | 140-170 | Basic and acidic residues | ||||
Sequence: EGNPDKSEESQGQPEENHHSERSRNHLERSL | ||||||
Compositional bias | 177-237 | Basic and acidic residues | ||||
Sequence: QGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQGD | ||||||
Region | 178-236 | RS-containing His-rich (RS-H); necessary for nuclear localization | ||||
Sequence: GQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQG | ||||||
Region | 238-287 | Leucine-zipper; required for RNA-binding and for its relocalization to the cytoplasm during cell division | ||||
Sequence: LVDTQSDLIATQRDLIATQKDLIATQRDLIATQRDLIVTQRDLVATERDL | ||||||
Region | 241-313 | Interaction with NXF1 | ||||
Sequence: TQSDLIATQRDLIATQKDLIATQRDLIATQRDLIVTQRDLVATERDLINQSGRSHGQSERHQRYSTGKNTITT | ||||||
Region | 290-313 | Disordered | ||||
Sequence: QSGRSHGQSERHQRYSTGKNTITT |
Phylogenomic databases
Family and domain databases
Sequence & Isoform
- Sequence statusComplete
This entry describes 2 isoforms produced by Alternative splicing.
Q9P127-1
This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.
- Name1
- Length313
- Mass (Da)35,937
- Last updated2000-10-01 v1
- ChecksumE041911D9BA1DC8B
Q9P127-2
- Name2
Computationally mapped potential isoform sequences
There is 1 potential isoform mapped to this entry
Entry | Entry name | Gene name | Length | ||
---|---|---|---|---|---|
Q5JX98 | Q5JX98_HUMAN | LUZP4 | 78 |
Features
Showing features for alternative sequence, compositional bias.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Alternative sequence | VSP_053926 | 1-32 | in isoform 2 | |||
Sequence: MASFRKLTLSEKVPPNHPSRKKVNFLDMSLDD → MLKKKRIKDRTIVKRNRLQDSNQKLIDIAIGE | ||||||
Alternative sequence | VSP_053927 | 33-114 | in isoform 2 | |||
Sequence: Missing | ||||||
Compositional bias | 38-62 | Basic and acidic residues | ||||
Sequence: ELEGTNAEEEKNKRQNHSKKESPSR | ||||||
Compositional bias | 63-77 | Basic residues | ||||
Sequence: QQSKAHRHRHRRGYS | ||||||
Compositional bias | 78-95 | Basic and acidic residues | ||||
Sequence: RCRSNSEEGNHDKKPSQK | ||||||
Compositional bias | 123-139 | Polar residues | ||||
Sequence: AQAEKNQGQSEGNQHQS | ||||||
Compositional bias | 140-170 | Basic and acidic residues | ||||
Sequence: EGNPDKSEESQGQPEENHHSERSRNHLERSL | ||||||
Compositional bias | 177-237 | Basic and acidic residues | ||||
Sequence: QGQLKRHHPQYERSHGQYKRSHGQSERSHGHSERSHGHSERSHGHSERSHGHSKRSRSQGD |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF124430 EMBL· GenBank· DDBJ | AAF28870.1 EMBL· GenBank· DDBJ | mRNA | ||
AK093369 EMBL· GenBank· DDBJ | BAG52698.1 EMBL· GenBank· DDBJ | mRNA | ||
AL109751 EMBL· GenBank· DDBJ | CAC09922.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
BC128134 EMBL· GenBank· DDBJ | AAI28135.1 EMBL· GenBank· DDBJ | mRNA |