Q9NZV6 · MSRB1_HUMAN
- ProteinMethionine-R-sulfoxide reductase B1
- GeneMSRB1
- StatusUniProtKB reviewed (Swiss-Prot)
- Organism
- Amino acids116 (go to sequence)
- Protein existenceEvidence at protein level
- Annotation score5/5
Function
function
Methionine-sulfoxide reductase that specifically reduces methionine (R)-sulfoxide back to methionine. While in many cases, methionine oxidation is the result of random oxidation following oxidative stress, methionine oxidation is also a post-translational modification that takes place on specific residue. Acts as a regulator of actin assembly by reducing methionine (R)-sulfoxide mediated by MICALs (MICAL1, MICAL2 or MICAL3) on actin, thereby promoting filament repolymerization. Plays a role in innate immunity by reducing oxidized actin, leading to actin repolymerization in macrophages.
Catalytic activity
- [thioredoxin]-disulfide + H2O + L-methionyl-[protein] = [thioredoxin]-dithiol + L-methionyl-(R)-S-oxide-[protein]
RHEA-COMP:10700 CHEBI:50058 Position: n/n+3+ CHEBI:15377 + RHEA-COMP:12313 = RHEA-COMP:10698 CHEBI:29950 Position: nCHEBI:29950 Position: n+3+ RHEA-COMP:12314
Cofactor
Note: Binds 1 zinc ion per subunit.
Features
Showing features for binding site, active site.
GO annotations
Aspect | Term | |
---|---|---|
Cellular Component | actin cytoskeleton | |
Cellular Component | cytosol | |
Cellular Component | nucleus | |
Molecular Function | actin binding | |
Molecular Function | L-methionine-(R)-S-oxide reductase activity | |
Molecular Function | peptide-methionine (R)-S-oxide reductase activity | |
Molecular Function | zinc ion binding | |
Biological Process | actin filament polymerization | |
Biological Process | innate immune response | |
Biological Process | protein repair |
Keywords
- Molecular function
- Biological process
- Ligand
Enzyme and pathway databases
Names & Taxonomy
Protein names
- Recommended nameMethionine-R-sulfoxide reductase B1
- EC number
- Short namesMsrB1
- Alternative names
Gene names
Organism names
- Organism
- Taxonomic lineageEukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo
Accessions
- Primary accessionQ9NZV6
- Secondary accessions
Proteomes
Organism-specific databases
Subcellular Location
Disease & Variants
Variants
We now provide the "Disease & Variants" viewer in its own tab.
The viewer provides 154 variants from UniProt as well as other sources including ClinVar and dbSNP.
Organism-specific databases
Miscellaneous
Chemistry
Genetic variation databases
PTM/Processing
Features
Showing features for chain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Chain | PRO_0000140321 | 1-116 | Methionine-R-sulfoxide reductase B1 | |||
Sequence: MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRSEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPKGKETSASQGH |
Post-translational modification
Truncated MSRB1/SEPX1 proteins produced by failed UGA/Sec decoding are ubiquitinated by some Cul2-RING E3 ubiquitin-protein ligase complexes (containing either PRAME, PRAMF6, PRAMF9 or FEM1C as substrate-recognition component).
Keywords
- PTM
Proteomic databases
PTM databases
Expression
Interaction
Binary interactions
Type | Entry 1 | Entry 2 | Number of experiments | Intact | |
---|---|---|---|---|---|
BINARY | Q9NZV6 | APP PRO_0000000092 P05067 | 4 | EBI-12330065, EBI-821758 | |
BINARY | Q9NZV6 | CLU P10909-5 | 10 | EBI-12330065, EBI-10961636 | |
BINARY | Q9NZV6 | CYSRT1 A8MQ03 | 3 | EBI-12330065, EBI-3867333 | |
BINARY | Q9NZV6 | IFT88 Q13099 | 3 | EBI-12330065, EBI-347427 | |
BINARY | Q9NZV6 | INCA1 Q0VD86 | 3 | EBI-12330065, EBI-6509505 | |
BINARY | Q9NZV6 | TRIM27 P14373 | 3 | EBI-12330065, EBI-719493 |
Protein-protein interaction databases
Miscellaneous
Structure
Family & Domains
Features
Showing features for domain.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Domain | 1-106 | MsrB | ||||
Sequence: MSFCSFFGGEVFQNHFEPGVYVCAKCGYELFSSRSKYAHSSPWPAFTETIHADSVAKRPEHNRSEALKVSCGKCGNGLGHEFLNDGPKPGQSRFUIFSSSLKFVPK |
Sequence similarities
Belongs to the MsrB Met sulfoxide reductase family.
Phylogenomic databases
Family and domain databases
Sequence
- Sequence statusComplete
- Length116
- Mass (Da)12,760
- Last updated2008-02-26 v3
- Checksum812B033BE02B7C0E
Computationally mapped potential isoform sequences
There are 3 potential isoforms mapped to this entry
Sequence caution
Features
Showing features for non-standard residue.
Type | ID | Position(s) | Description | |||
---|---|---|---|---|---|---|
Non-standard residue | 95 | Selenocysteine | ||||
Sequence: U |
Keywords
- Coding sequence diversity
- Technical term
Sequence databases
Nucleotide Sequence | Protein Sequence | Molecule Type | Status | |
---|---|---|---|---|
AF166124 EMBL· GenBank· DDBJ | AAF21429.1 EMBL· GenBank· DDBJ | mRNA | ||
AF187272 EMBL· GenBank· DDBJ | AAG17033.1 EMBL· GenBank· DDBJ | mRNA | ||
AF161388 EMBL· GenBank· DDBJ | AAF28948.1 EMBL· GenBank· DDBJ | mRNA | Sequence problems. | |
AE006640 EMBL· GenBank· DDBJ | AAK61300.1 EMBL· GenBank· DDBJ | Genomic DNA | ||
AC005363 EMBL· GenBank· DDBJ | - | Genomic DNA | No translation available. | |
BC003127 EMBL· GenBank· DDBJ | AAH03127.2 EMBL· GenBank· DDBJ | mRNA |