Q9NZC4 · EHF_HUMAN

  • Protein
    ETS homologous factor
  • Gene
    EHF
  • Status
    UniProtKB reviewed (Swiss-Prot)
  • Amino acids
  • Protein existence
    Evidence at protein level
  • Annotation score
    5/5

Function

function

Transcriptional activator that may play a role in regulating epithelial cell differentiation and proliferation. May act as a repressor for a specific subset of ETS/AP-1-responsive genes and as a modulator of the nuclear response to mitogen-activated protein kinase signaling cascades. Binds to DNA sequences containing the consensus nucleotide core sequence GGAA. Involved in regulation of TNFRSF10B/DR5 expression through Ets-binding sequences on the TNFRSF10B/DR5 promoter. May contribute to development and carcinogenesis by acting as a tumor suppressor gene or anti-oncogene.

Features

Showing features for dna binding.

130020406080100120140160180200220240260280300
TypeIDPosition(s)Description
DNA binding207-289ETS

GO annotations

all annotationsall molecular functionvirus receptor activitydna bindingrna bindingcytoskeletal motor activitycatalytic activitygtpase activitystructural molecule activitytransporter activitycytoskeletal protein bindinglipid bindingcyclase activityantioxidant activityoxidoreductase activitytransferase activityhydrolase activitylyase activityisomerase activityligase activityprotein tag activitycargo receptor activityhistone bindingprotein folding chaperonetranslation regulator activitynutrient reservoir activityreceptor ligand activitymolecular transducer activitymolecular adaptor activitytoxin activitycell adhesion mediator activitymolecular function regulator activityvirus coreceptor activitycatalytic activity, acting on a proteincatalytic activity, acting on dnacatalytic activity, acting on rnamolecular carrier activitytranscription regulator activitygeneral transcription initiation factor activitymolecular sensor activitymolecular sequestering activityatp-dependent activityother molecular functionall biological processmitotic cell cyclecytokinesiscytoplasmic translationimmune system processmuscle system processcirculatory system processrenal system processrespiratory system processcarbohydrate metabolic processgeneration of precursor metabolites and energydna replicationdna repairdna recombinationchromatin organizationdna-templated transcriptionregulation of dna-templated transcriptiontrna metabolic processprotein foldingprotein glycosylationamino acid metabolic processmodified amino acid metabolic processlipid metabolic processvitamin metabolic processsulfur compound metabolic processintracellular protein transportnucleocytoplasmic transportautophagyinflammatory responsemitochondrion organizationcytoskeleton organizationmicrotubule-based movementperoxisome organizationlysosome organizationchromosome segregationcell adhesionestablishment or maintenance of cell polarityprogrammed cell deathphotosynthesismrna metabolic processsnrna metabolic processvesicle-mediated transportreproductive processdigestive system processsignalingcell differentiationprotein catabolic processextracellular matrix organizationregulatory ncrna-mediated gene silencingtelomere organizationcell junction organizationwound healingribosome biogenesiscilium organizationanatomical structure developmentcell motilitynervous system processendocrine processprotein maturationtransmembrane transportnucleobase-containing small molecule metabolic processhepaticobiliary system processmembrane organizationprotein-containing complex assemblycell wall organization or biogenesisnitrogen cycle metabolic processprotein localization to plasma membranedefense response to other organismdetoxificationmeiotic nuclear divisionmitotic nuclear divisionmitochondrial gene expressioncarbohydrate derivative metabolic processother biological processall cellular componentnuclear chromosomeextracellular regionextracellular spacecell wallnucleusnuclear envelopenucleoplasmchromosomenucleolusmitochondrionlysosomeendosomevacuoleperoxisomeendoplasmic reticulumgolgi apparatuslipid dropletmicrotubule organizing centercytosolribosomecytoskeletonplasma membraneciliumplastidthylakoidexternal encapsulating structureextracellular matrixcytoplasmic vesicleorganelleother cellular component
Cell color indicative of number of GO terms
AspectTerm
Cellular Componentchromatin
Cellular ComponentGolgi apparatus
Cellular Componentnucleoplasm
Cellular Componentnucleus
Molecular FunctionDNA binding
Molecular FunctionDNA-binding transcription activator activity, RNA polymerase II-specific
Molecular FunctionDNA-binding transcription factor activity, RNA polymerase II-specific
Molecular FunctionRNA polymerase II cis-regulatory region sequence-specific DNA binding
Biological Processepithelial cell differentiation
Biological Processpositive regulation of transcription by RNA polymerase II
Biological Processregulation of transcription by RNA polymerase II

Keywords

Enzyme and pathway databases

Names & Taxonomy

Protein names

  • Recommended name
    ETS homologous factor
  • Short names
    hEHF
  • Alternative names
    • ETS domain-containing transcription factor
    • Epithelium-specific Ets transcription factor 3 (ESE-3)

Gene names

    • Name
      EHF
    • Synonyms
      ESE3, ESE3B
      , ESEJ

Organism names

  • Taxonomic identifier
  • Taxonomic lineage
    Eukaryota > Metazoa > Chordata > Craniata > Vertebrata > Euteleostomi > Mammalia > Eutheria > Euarchontoglires > Primates > Haplorrhini > Catarrhini > Hominidae > Homo

Accessions

  • Primary accession
    Q9NZC4
  • Secondary accessions
    • D3DR08
    • D3DR10
    • E9PSB2
    • Q9H509
    • Q9UKF9

Proteomes

Organism-specific databases

Subcellular Location

Keywords

Disease & Variants

Features

Showing features for natural variant.

TypeIDPosition(s)Description
Natural variantVAR_04894196in dbSNP:rs9804460

Variants

We now provide the "Disease & Variants" viewer in its own tab.

The viewer provides 341 variants from UniProt as well as other sources including ClinVar and dbSNP.

Go to variant viewer

Organism-specific databases

Miscellaneous

Genetic variation databases

PTM/Processing

Features

Showing features for chain, modified residue (large scale data).

TypeIDPosition(s)SourceDescription
ChainPRO_00002579691-300UniProtETS homologous factor
Modified residue (large scale data)184PRIDEPhosphoserine

Proteomic databases

PTM databases

Expression

Tissue specificity

Expressed exclusively in tissues with a high content of epithelial cells. Highly expressed in salivary gland, mammary gland, prostate, and lung. Weakly expressed in kidney and colon. Not detected in heart, brain, placenta, liver, skeletal muscle, spleen, thymus, testis, ovary, small intestine or peripheral blood leukocytes.

Induction

By IL1B/interleukin-1 beta and TNF in bronchial smooth muscle cells and fibroblasts. By IL10/interleukin-10 and IFNG/IFN-gamma in monocyte-derived dendritic cells.

Gene expression databases

Organism-specific databases

Interaction

Binary interactions

TypeEntry 1Entry 2Number of experimentsIntact
BINARY Q9NZC4KPRP Q5T7492EBI-1053347, EBI-10981970

Protein-protein interaction databases

Miscellaneous

Structure

Family & Domains

Features

Showing features for domain, region.

TypeIDPosition(s)Description
Domain29-115PNT
Region183-202Disordered

Domain

The PNT domain acts as a transcriptional activator.

Sequence similarities

Belongs to the ETS family.

Phylogenomic databases

Family and domain databases

Sequence & Isoforms

Align isoforms (3)
  • Sequence status
    Complete

This entry describes 3 isoforms produced by Alternative splicing.

Q9NZC4-1

This isoform has been chosen as the canonical sequence. All positional information in this entry refers to it. This is also the sequence that appears in the downloadable versions of the entry.

  • Name
    1
  • Synonyms
    ESE-3B
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Length
    300
  • Mass (Da)
    34,892
  • Last updated
    2000-10-01 v1
  • Checksum
    5CABB38BAF852ED0
MILEGGGVMNLNPGNNLLHQPPAWTDSYSTCNVSSGFFGGQWHEIHPQYWTKYQVWEWLQHLLDTNQLDANCIPFQEFDINGEHLCSMSLQEFTRAAGTAGQLLYSNLQHLKWNGQCSSDLFQSTHNVIVKTEQTEPSIMNTWKDENYLYDTNYGSTVDLLDSKTFCRAQISMTTTSHLPVAESPDMKKEQDPPAKCHTKKHNPRGTHLWEFIRDILLNPDKNPGLIKWEDRSEGVFRFLKSEAVAQLWGKKKNNSSMTYEKLSRAMRYYYKREILERVDGRRLVYKFGKNARGWRENEN

Q9NZC4-2

  • Name
    2
  • Synonyms
    ESE-3A
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical

Q9NZC4-3

  • Name
    3
  • See also
    sequence in UniParc or sequence clusters in UniRef
  • Differences from canonical
    • 1-1: M → MGLPERRGLVLLLSLAEILFKIM

Computationally mapped potential isoform sequences

There are 4 potential isoforms mapped to this entry

View all
EntryEntry nameGene nameLength
E9PPS9E9PPS9_HUMANEHF126
E9PQX0E9PQX0_HUMANEHF158
E9PQR6E9PQR6_HUMANEHF173
E9PN75E9PN75_HUMANEHF166

Features

Showing features for alternative sequence, sequence conflict.

TypeIDPosition(s)Description
Alternative sequenceVSP_0463731in isoform 3
Sequence conflict40in Ref. 2; AAD30990/AAD30991
Alternative sequenceVSP_052190159-181in isoform 2
Sequence conflict163in Ref. 2; AAD30991
Sequence conflict169in Ref. 2; AAD30991
Sequence conflict196in Ref. 1; AAF06998

Keywords

Sequence databases

Nucleotide SequenceProtein SequenceMolecule TypeStatus
AF170583
EMBL· GenBank· DDBJ
AAF06998.1
EMBL· GenBank· DDBJ
mRNA
AF124438
EMBL· GenBank· DDBJ
AAD30990.1
EMBL· GenBank· DDBJ
mRNA
AF124439
EMBL· GenBank· DDBJ
AAD30991.1
EMBL· GenBank· DDBJ
mRNA
AF212848
EMBL· GenBank· DDBJ
AAF61670.1
EMBL· GenBank· DDBJ
mRNA
AF203977
EMBL· GenBank· DDBJ
AAG35644.1
EMBL· GenBank· DDBJ
mRNA
AY882601
EMBL· GenBank· DDBJ
AAW80658.1
EMBL· GenBank· DDBJ
mRNA
AK310867
EMBL· GenBank· DDBJ
-mRNA No translation available.
AC087783
EMBL· GenBank· DDBJ
-Genomic DNA No translation available.
AL157952
EMBL· GenBank· DDBJ
CAC12700.1
EMBL· GenBank· DDBJ
Genomic DNA
AL157952
EMBL· GenBank· DDBJ
CAC12701.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68162.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68163.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68164.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68165.1
EMBL· GenBank· DDBJ
Genomic DNA
CH471064
EMBL· GenBank· DDBJ
EAW68166.1
EMBL· GenBank· DDBJ
Genomic DNA
BC038995
EMBL· GenBank· DDBJ
AAH38995.1
EMBL· GenBank· DDBJ
mRNA

Genome annotation databases

Similar Proteins

Disclaimer

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